{"id":"https://openalex.org/W2053875786","doi":"https://doi.org/10.1254/jjp.63.285","title":"Release of Sympathetic Neurotransmitter Evoked by Electrical Stimulation Is Increased in the Chronically Decentralized Artery","display_name":"Release of Sympathetic Neurotransmitter Evoked by Electrical Stimulation Is Increased in the Chronically Decentralized Artery","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2053875786","doi":"https://doi.org/10.1254/jjp.63.285","mag":"2053875786","pmid":"https://pubmed.ncbi.nlm.nih.gov/7906317"},"language":"en","primary_location":{"id":"doi:10.1254/jjp.63.285","doi":"https://doi.org/10.1254/jjp.63.285","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.63.285","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1254/jjp.63.285","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113651922","display_name":"Hiromichi Tsuru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Tsuru","raw_affiliation_strings":["Department of Pharmacology, Hiroshima University School of Medicine, Japan","Department of Pharmacology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Hiroshima University School of Medicine, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Pharmacology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089790203","display_name":"Sumiko Negita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumiko Negita","raw_affiliation_strings":["Department of Pharmacology and Kasumi, Minami-ku, Hiroshima 734, Japan","Department of Pharmacology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Kasumi, Minami-ku, Hiroshima 734, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111731189","display_name":"Yasuhiro Teranishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Teranishi","raw_affiliation_strings":["Department of Physiology, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima 734, Japan","Department of Physiology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima 734, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Physiology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113488913","display_name":"Masashi Sasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Sasa","raw_affiliation_strings":["Department of Pharmacology and Kasumi, Minami-ku, Hiroshima 734, Japan","Department of Pharmacology, Hiroshima University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Kasumi, Minami-ku, Hiroshima 734, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Hiroshima University School of Medicine","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"63","issue":"3","first_page":"285","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.12849999964237213,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transmural-nerve-stimulation","display_name":"transmural nerve stimulation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/supersensitivity","display_name":"supersensitivity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/superior-cervical-ganglion","display_name":"superior cervical ganglion","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ear-artery","display_name":"ear artery","score":0.7200000286102295},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sympathetic-nerve-terminals","display_name":"sympathetic nerve terminals","score":0.5569999814033508},{"id":"https://openalex.org/keywords/catecholamine-uptake","display_name":"catecholamine uptake","score":0.7429999709129333},{"id":"https://openalex.org/keywords/sympathetic-denervation","display_name":"sympathetic denervation","score":0.4399999976158142},{"id":"https://openalex.org/keywords/sympathetic-reinnervation","display_name":"sympathetic reinnervation","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7052686810493469},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.6447626352310181},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.5750197172164917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5684284567832947},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.5481217503547668},{"id":"https://openalex.org/C2778993773","wikidata":"https://www.wikidata.org/wiki/Q1493493","display_name":"Superior cervical ganglion","level":2,"score":0.5342077016830444},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.5256734490394592},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5051172375679016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4895881116390228},{"id":"https://openalex.org/C3018430268","wikidata":"https://www.wikidata.org/wiki/Q17157299","display_name":"Nerve stimulation","level":3,"score":0.48050224781036377},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.465260773897171},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4203425645828247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31315451860427856},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22341397404670715},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19189700484275818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061521053314208984}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003714","descriptor_name":"Denervation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004423","descriptor_name":"Ear","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017783","descriptor_name":"Superior Cervical Ganglion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1254/jjp.63.285","doi":"https://doi.org/10.1254/jjp.63.285","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.63.285","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:7906317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7906317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1254/jjp.63.285","doi":"https://doi.org/10.1254/jjp.63.285","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.63.285","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1522815820","https://openalex.org/W1882777763","https://openalex.org/W1974993021","https://openalex.org/W1996679429","https://openalex.org/W2009113575","https://openalex.org/W2021990578","https://openalex.org/W2026726749","https://openalex.org/W2032963433","https://openalex.org/W2035855649","https://openalex.org/W2061362602","https://openalex.org/W2064001804","https://openalex.org/W2064900646","https://openalex.org/W2068617048","https://openalex.org/W2074388111","https://openalex.org/W2083304301","https://openalex.org/W2091031608","https://openalex.org/W2092771620","https://openalex.org/W2156401020","https://openalex.org/W2227591748","https://openalex.org/W2244390472","https://openalex.org/W2269956783","https://openalex.org/W2282205215","https://openalex.org/W2297255209","https://openalex.org/W6649341303","https://openalex.org/W6658800454","https://openalex.org/W6693820098"],"related_works":["https://openalex.org/W2074388111","https://openalex.org/W1974993021","https://openalex.org/W1545494857","https://openalex.org/W2064001804","https://openalex.org/W2139330672","https://openalex.org/W2013907040","https://openalex.org/W2013662778","https://openalex.org/W2002524081","https://openalex.org/W2886957553","https://openalex.org/W2021506248"],"abstract_inverted_index":{"The":[0,33,64],"present":[1],"study":[2],"was":[3,36,88,106,117,137],"performed":[4],"to":[5,25,45,170,178,196,204],"confirm":[6],"our":[7],"previous":[8],"proposal":[9],"that":[10,99,167],"the":[11,19,31,41,46,52,62,67,74,101,120,131,142,148,163,168,179,197],"increase":[12,65],"in":[13,30,66,119,141,146,186,202],"neurotransmitter":[14],"release":[15,199],"is":[16,175],"responsible":[17],"for":[18,85,127],"supersensitivity":[20,169],"of":[21,123,144,200,207],"chronically":[22,75],"decentralized":[23,37,76,134],"artery":[24,35,149],"transmural":[26],"nerve":[27,188],"stimulation":[28],"(TNS)":[29],"rabbit.":[32],"ear":[34,53],"unilaterally":[38],"by":[39,71,157],"removing":[40],"preganglionic":[42],"fiber":[43],"proximal":[44],"superior":[47],"cervical":[48],"ganglion":[49],"(SCG),":[50],"and":[51,55,95,133,150,183,190],"arteries":[54],"SCG":[56,151],"were":[57],"dissected":[58],"8":[59],"weeks":[60],"after":[61,152,172],"operation.":[63],"tritium":[68],"overflow":[69],"induced":[70],"TNS":[72,171],"from":[73,100],"artery,":[77,103],"which":[78],"had":[79],"been":[80],"incubated":[81],"with":[82],"3H-noradrenaline":[83],"(NA)":[84],"1":[86,128],"hr,":[87],"markedly":[89],"increased":[90,198],"at":[91,109],"lower":[92],"frequencies":[93,111,206],"(0.1":[94],"0.2":[96],"Hz)":[97],"than":[98],"control":[102,132],"whereas":[104],"there":[105],"no":[107,139],"difference":[108,116],"higher":[110],"(>":[112],"0.5":[113],"Hz).":[114],"No":[115],"observed":[118],"neuronal":[121],"uptake":[122,182],"3H-NA":[124],"during":[125],"incubation":[126],"hr":[129],"between":[130],"arteries.":[135],"There":[136],"also":[138],"change":[140],"contents":[143],"catecholamines":[145],"both":[147],"chronic":[153,173],"decentralization,":[154],"when":[155],"assayed":[156],"a":[158],"radioenzymatic":[159],"procedure.":[160],"In":[161],"conclusion,":[162],"results":[164],"obtained":[165],"indicate":[166],"decentralization":[174],"not":[176],"due":[177,195],"deranged":[180],"catecholamine":[181],"storage":[184],"mechanisms":[185],"adrenergic":[187],"terminals":[189],"augmented":[191],"transmitter":[192,201],"biosynthesis,":[193],"but":[194],"response":[203],"low":[205],"TNS.":[208]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}