{"id":"https://openalex.org/W2053872302","doi":"https://doi.org/10.1172/jci118565","title":"Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.","display_name":"Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.","publication_year":1996,"publication_date":"1996-03-15","ids":{"openalex":"https://openalex.org/W2053872302","doi":"https://doi.org/10.1172/jci118565","mag":"2053872302","pmid":"https://pubmed.ncbi.nlm.nih.gov/8617876","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507203"},"language":"en","primary_location":{"id":"doi:10.1172/jci118565","doi":"https://doi.org/10.1172/jci118565","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118565","pdf_url":"http://www.jci.org/articles/view/118565/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/118565/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Sankar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Sankar","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015345740","display_name":"Negar Mahooti-Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Mahooti-Brooks","raw_affiliation_strings":["Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510","Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079041720","display_name":"Lieselotte Bensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Bensen","raw_affiliation_strings":["Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510","Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108509520","display_name":"Thomas L. McCarthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T L McCarthy","raw_affiliation_strings":["Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510","Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016134289","display_name":"Joseph A. Madri","orcid":"https://orcid.org/0000-0003-0008-2440","observed_orcids":["https://orcid.org/0000-0003-0008-2440"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Madri","raw_affiliation_strings":["Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510","Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and *Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pa-thology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.8255,"has_fulltext":true,"cited_by_count":156,"citation_normalized_percentile":{"value":0.9708988,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"97","issue":"6","first_page":"1436","last_page":"1446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/three-dimensional-collagen-gel-culture","display_name":"three-dimensional collagen gel culture","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/fibronectin-expression","display_name":"fibronectin expression","score":0.9520000219345093},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8140000104904175},{"id":"https://openalex.org/keywords/receptor-surface-expression","display_name":"receptor surface expression","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.7514837980270386},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6010844111442566},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5554903149604797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5053597092628479},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.47904765605926514},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.47028589248657227},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46566155552864075},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.44744873046875},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.426201730966568},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42192837595939636},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.42031213641166687},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.41406288743019104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40821295976638794},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40315258502960205},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.37960362434387207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10254237055778503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0865052342414856},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci118565","doi":"https://doi.org/10.1172/jci118565","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118565","pdf_url":"http://www.jci.org/articles/view/118565/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507203","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:8617876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8617876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci118565","doi":"https://doi.org/10.1172/jci118565","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118565","pdf_url":"http://www.jci.org/articles/view/118565/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2764783756","display_name":"CELL AND MOLECULAR PATHOBIOLOGY OF RENAL DISEASE","funder_award_id":"P01DK038979","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3401822921","display_name":null,"funder_award_id":"R0-1HL29373","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4003198984","display_name":"Control of TGF-beta Activity in Bone","funder_award_id":"R01AR039201","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053872302.pdf","grobid_xml":"https://content.openalex.org/works/W2053872302.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W210896705","https://openalex.org/W1010135390","https://openalex.org/W1494055834","https://openalex.org/W1497695953","https://openalex.org/W1505978562","https://openalex.org/W1508798492","https://openalex.org/W1509400195","https://openalex.org/W1510586846","https://openalex.org/W1511537290","https://openalex.org/W1551856347","https://openalex.org/W1579384758","https://openalex.org/W1600831053","https://openalex.org/W1608169825","https://openalex.org/W1677719282","https://openalex.org/W1882983705","https://openalex.org/W1908718505","https://openalex.org/W1931154590","https://openalex.org/W1965094170","https://openalex.org/W1966885634","https://openalex.org/W1967346679","https://openalex.org/W1968538228","https://openalex.org/W1973630430","https://openalex.org/W1975173778","https://openalex.org/W1975387231","https://openalex.org/W1979356105","https://openalex.org/W1983031935","https://openalex.org/W1994091018","https://openalex.org/W1994937757","https://openalex.org/W1996313200","https://openalex.org/W2003598961","https://openalex.org/W2018289835","https://openalex.org/W2019050177","https://openalex.org/W2020977918","https://openalex.org/W2021263701","https://openalex.org/W2021410150","https://openalex.org/W2028749490","https://openalex.org/W2029545106","https://openalex.org/W2035819392","https://openalex.org/W2040583312","https://openalex.org/W2041708400","https://openalex.org/W2043558120","https://openalex.org/W2044251823","https://openalex.org/W2050183943","https://openalex.org/W2059211912","https://openalex.org/W2061079860","https://openalex.org/W2067055348","https://openalex.org/W2077142274","https://openalex.org/W2081319204","https://openalex.org/W2084877581","https://openalex.org/W2085216816","https://openalex.org/W2088738897","https://openalex.org/W2091724639","https://openalex.org/W2092139196","https://openalex.org/W2099543104","https://openalex.org/W2100837269","https://openalex.org/W2104206376","https://openalex.org/W2107908226","https://openalex.org/W2115269733","https://openalex.org/W2115393190","https://openalex.org/W2131211068","https://openalex.org/W2131405836","https://openalex.org/W2134812217","https://openalex.org/W2136819827","https://openalex.org/W2137518304","https://openalex.org/W2138229905","https://openalex.org/W2143851663","https://openalex.org/W2163380244","https://openalex.org/W2167578487","https://openalex.org/W2169811715","https://openalex.org/W2246378037"],"related_works":["https://openalex.org/W1882983705","https://openalex.org/W2138229905","https://openalex.org/W2104206376","https://openalex.org/W2040583312","https://openalex.org/W2035819392","https://openalex.org/W2163380244","https://openalex.org/W2162031629","https://openalex.org/W2144501249","https://openalex.org/W1846670216","https://openalex.org/W1981546449"],"abstract_inverted_index":{"Microvascular":[0],"endothelial":[1],"cells":[2,106,128],"(RFCs)":[3],"cultured":[4,30],"in":[5,31,55,75,107,113,129,142,164,213],"two-dimensional":[6],"(2D)":[7],"cultures":[8,115,145,170],"proliferate":[9,38],"rapidly":[10],"and":[11,26,40,63,69,84,109,167,209],"exhibit":[12],"an":[13],"undifferentiated":[14],"phenotype.":[15],"Addition":[16],"of":[17,47,120,135,150,175,192,204,222,229],"transforming":[18],"growth":[19],"factor":[20],"beta1":[21,51,59,137,194,208],"(TGFbeta1)":[22],"increases":[23,60],"fibronectin":[24,61,160],"expression":[25,62,221],"inhibits":[27],"proliferation.":[28],"RFCs":[29,112,205,230],"three-dimensional":[32],"(3D)":[33],"type":[34,82,123,152,177,185,197],"I":[35,83,178,198],"collagen":[36],"gels":[37],"slowly":[39],"are":[41],"refractory":[42],"to":[43,90,206,231],"the":[44,79,100,151,176,184,189,196,201,214,219,227],"anti-proliferative":[45],"effects":[46],"TGF":[48,50,58,80,96,101,136,193,207,223,232],"beta1.":[49,233],"promotes":[52],"tube":[53],"formation":[54],"3D":[56,76,110,114,168],"cultures.":[57,77,111,131],"urokinase":[64],"plasminogen":[65,70],"activator":[66,71],"(uPA)":[67],"activity":[68],"inhibitor-1":[72],"(PAI-1)":[73],"levels":[74],"Since":[78],"beta":[81,102,224],"II":[85,124,153,186],"receptors":[86],"have":[87],"been":[88],"reported":[89],"regulate":[91],"different":[92],"activities":[93],"induced":[94],"by":[95],"beta1,":[97],"we":[98],"compared":[99,126],"receptor":[103,125,187,199],"profiles":[104],"on":[105,138,159],"2D":[108,130,144,166],"exhibited":[116],"a":[117,147,172],"significant":[118],"loss":[119],"cell":[121],"surface":[122,220],"with":[127],"The":[132],"inhibitory":[133],"effect":[134,158,191],"proliferation":[139],"is":[140,162],"suppressed":[141],"transfected":[143,169],"expressing":[146,171],"truncated":[148,173],"form":[149,174],"receptor,":[154],"while":[155,195],"its":[156],"stimulatory":[157],"production":[161],"reduced":[163],"both":[165],"receptor.":[179],"These":[180],"data":[181],"suggest":[182],"that":[183,211],"mediates":[188,200],"antiproliferative":[190],"matrix":[202,215],"response":[203],"demonstrate":[210],"changes":[212],"environment":[216],"can":[217],"modulate":[218],"receptors,":[225],"altering":[226],"responsiveness":[228]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
