{"id":"https://openalex.org/W2053796974","doi":"https://doi.org/10.1210/endo-24-1-87","title":"CALORIGENIC POTENCY OF FREE THYROXINE BY MOUTH","display_name":"CALORIGENIC POTENCY OF FREE THYROXINE BY MOUTH","publication_year":1939,"publication_date":"1939-01-01","ids":{"openalex":"https://openalex.org/W2053796974","doi":"https://doi.org/10.1210/endo-24-1-87","mag":"2053796974"},"language":"en","primary_location":{"id":"doi:10.1210/endo-24-1-87","doi":"https://doi.org/10.1210/endo-24-1-87","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-24-1-87","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111621275","display_name":"Willard Owen Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. O. THOMPSON","raw_affiliation_strings":["From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113903345","display_name":"Phebe K. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. K. THOMPSON","raw_affiliation_strings":["From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003234402","display_name":"S G Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. G. TAYLOR","raw_affiliation_strings":["From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026577954","display_name":"Lois F. N. Dickie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. F. N. DICKIE","raw_affiliation_strings":["From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Rush Medical College of the University of Chicago and the Presbyterian and Coo/ County Hospitals CHICAGO, ILLINOIS","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.14466546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":"87","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/calorigenic-effect","display_name":"calorigenic effect","score":0.7570000290870667},{"id":"https://openalex.org/keywords/basal-metabolic-rate","display_name":"basal metabolic rate","score":0.7559999823570251},{"id":"https://openalex.org/keywords/myxedema","display_name":"myxedema","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.8840000033378601},{"id":"https://openalex.org/keywords/maintenance-dose","display_name":"maintenance dose","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8020933270454407},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7898786067962646},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.7038516998291016},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.554326057434082},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.44942545890808105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4388270080089569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3591044545173645},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2144768238067627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15360048413276672},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1210/endo-24-1-87","doi":"https://doi.org/10.1210/endo-24-1-87","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-24-1-87","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970772457","https://openalex.org/W2143807754","https://openalex.org/W2046812226","https://openalex.org/W2138826452","https://openalex.org/W2322526383","https://openalex.org/W2083058031","https://openalex.org/W2470468758","https://openalex.org/W2329526983","https://openalex.org/W2329929085","https://openalex.org/W2599806820"],"abstract_inverted_index":{"WE":[0],"HAVE":[1],"previously":[2],"shown":[3],"that":[4],"synthetic":[5],"thyroxine,":[6],"when":[7,65,76],"admin'":[8],"istered":[9],"by":[10,130],"mouth":[11],"in":[12,26,29,38,78],"single":[13,39],"doses":[14,40,134],"of":[15,41,86,92,121],"from":[16,42],"10":[17,43],"to":[18,44,108,115],"ioo":[19],"mg.,":[20,46],"does":[21,59],"not":[22],"producea":[23],"definite":[24],"increase":[25],"basal":[27],"metabolism":[28],"patients":[30],"with":[31],"myxedema.":[32],"When":[33],"administered":[34,66],"into":[35],"the":[36,55,68,84,89,98,119,126],"duodenum":[37],"50":[45],"it":[47,106],"is":[48],"likewise":[49],"without":[50],"demonstrable":[51],"effect":[52,75,120],"(1).":[53],"On":[54],"other":[56],"hand,":[57],"thyroxine":[58,94,96,122],"produce":[60],"a":[61,72,136],"clear-cut":[62],"calorigenic":[63],"response":[64],"as":[67,97,125],"monosodium":[69,93],"salt":[70],"and":[71,105],"still":[73],"greater":[74],"given":[77,123],"an":[79],"alkaline":[80],"solution":[81],"(2).":[82],"In":[83],"course":[85],"observations":[87],"on":[88],"maintenance":[90],"dose":[91],"(3),":[95],"free":[99],"amino":[100],"acid":[101],"was":[102],"accidentally":[103],"substituted":[104],"appeared":[107],"possess":[109],"slight":[110],"activity.":[111],"It,therefore,":[112],"seemed":[113],"desirable":[114],"determine":[116],"more":[117],"precisely":[118],"orally":[124],"fre":[127],"eamino":[128],"acid,":[129],"administering":[131],"large":[132],"daily":[133],"for":[135],"comparativelylong":[137],"period.":[138]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}