{"id":"https://openalex.org/W2053775643","doi":"https://doi.org/10.1021/jm101591j","title":"Pyrimidine Nucleotides with 4-Alkyloxyimino and Terminal Tetraphosphate \u03b4-Ester Modifications as Selective Agonists of the P2Y4Receptor","display_name":"Pyrimidine Nucleotides with 4-Alkyloxyimino and Terminal Tetraphosphate \u03b4-Ester Modifications as Selective Agonists of the P2Y4Receptor","publication_year":2011,"publication_date":"2011-04-29","ids":{"openalex":"https://openalex.org/W2053775643","doi":"https://doi.org/10.1021/jm101591j","mag":"2053775643","pmid":"https://pubmed.ncbi.nlm.nih.gov/21528910","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117126"},"language":"en","primary_location":{"id":"doi:10.1021/jm101591j","doi":"https://doi.org/10.1021/jm101591j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm101591j","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117126","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hiroshi Maruoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Maruoka","raw_affiliation_strings":["Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045282217","display_name":"M. P. Suresh Jayasekara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. P. Suresh Jayasekara","raw_affiliation_strings":["Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027883845","display_name":"Matthew O. Barrett","orcid":"https://orcid.org/0000-0001-7851-0308","observed_orcids":["https://orcid.org/0000-0001-7851-0308"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew O. Barrett","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084437211","display_name":"Derek A. Franklin","orcid":"https://orcid.org/0000-0002-1568-1537","observed_orcids":["https://orcid.org/0000-0002-1568-1537"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek A. Franklin","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075179551","display_name":"Sonia de Castro","orcid":"https://orcid.org/0000-0002-3838-6856","observed_orcids":["https://orcid.org/0000-0002-3838-6856"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia de Castro","raw_affiliation_strings":["Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000991221","display_name":"Nathaniel J. Kim","orcid":"https://orcid.org/0009-0004-8209-1774","observed_orcids":["https://orcid.org/0009-0004-8209-1774"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Kim","raw_affiliation_strings":["Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021219075","display_name":"Stefano Costanzi","orcid":"https://orcid.org/0000-0003-3183-7332","observed_orcids":["https://orcid.org/0000-0003-3183-7332"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Costanzi","raw_affiliation_strings":["Laboratory of Biological Modeling, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biological Modeling, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108821664","display_name":"T. Kendall Harden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Kendall Harden","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599-7365, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091587615","display_name":"Kenneth A. Jacobson","orcid":"https://orcid.org/0000-0001-8104-1493","observed_orcids":["https://orcid.org/0000-0001-8104-1493"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth A. Jacobson","raw_affiliation_strings":["Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091587615"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.3579,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.96617008,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"54","issue":"12","first_page":"4018","last_page":"4033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2y4-receptor","display_name":"P2Y4 receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/p2y2-receptor","display_name":"P2Y2 receptor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.5789999961853027},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7689999938011169},{"id":"https://openalex.org/keywords/phospholipase-c-activation","display_name":"phospholipase C activation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ligand-stability","display_name":"ligand stability","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9142608642578125},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7815879583358765},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.6810375452041626},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.551083505153656},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5071029663085938},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4922262728214264},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.4868675768375397},{"id":"https://openalex.org/C160225129","wikidata":"https://www.wikidata.org/wiki/Q6591687","display_name":"P2Y receptor","level":4,"score":0.48144930601119995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41455256938934326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1506127417087555},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014500","descriptor_name":"Uracil Nucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014500","descriptor_name":"Uracil Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014500","descriptor_name":"Uracil Nucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018048","descriptor_name":"Receptors, Purinergic P2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058910","descriptor_name":"Purinergic P2 Receptor Agonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D058910","descriptor_name":"Purinergic P2 Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058910","descriptor_name":"Purinergic P2 Receptor Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/jm101591j","doi":"https://doi.org/10.1021/jm101591j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm101591j","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:21528910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21528910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2385453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117126","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3117126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2385453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117126","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2225345073","display_name":null,"funder_award_id":"Z99 DK999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2409839582","display_name":"P2Y-Purinergic Receptors","funder_award_id":"R01GM038213","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G40790798","display_name":null,"funder_award_id":"GM38213","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000870085","display_name":"Development of P2Y Receptor Ligands","funder_award_id":"ZIADK031116","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000915511","display_name":"Computer Modeling of G Protein-Coupled Receptors","funder_award_id":"ZIADK031126","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W803871593","https://openalex.org/W960523947","https://openalex.org/W1545273928","https://openalex.org/W1559190352","https://openalex.org/W1967490656","https://openalex.org/W1968962803","https://openalex.org/W1977994168","https://openalex.org/W1981617725","https://openalex.org/W1985107522","https://openalex.org/W1988661280","https://openalex.org/W2006853049","https://openalex.org/W2008975884","https://openalex.org/W2010428132","https://openalex.org/W2012894470","https://openalex.org/W2014661781","https://openalex.org/W2016229228","https://openalex.org/W2016501431","https://openalex.org/W2020880088","https://openalex.org/W2021213286","https://openalex.org/W2025781453","https://openalex.org/W2032143666","https://openalex.org/W2034756826","https://openalex.org/W2038179437","https://openalex.org/W2050066735","https://openalex.org/W2063831197","https://openalex.org/W2067838820","https://openalex.org/W2068613384","https://openalex.org/W2075614910","https://openalex.org/W2087153895","https://openalex.org/W2096405956","https://openalex.org/W2096550848","https://openalex.org/W2097455693","https://openalex.org/W2100452437","https://openalex.org/W2107405411","https://openalex.org/W2114935719","https://openalex.org/W2128635872","https://openalex.org/W2152853006","https://openalex.org/W4230526395"],"related_works":["https://openalex.org/W2334461011","https://openalex.org/W7098902962","https://openalex.org/W2010428132","https://openalex.org/W4300338221","https://openalex.org/W4300932913","https://openalex.org/W2315355035","https://openalex.org/W4300312372","https://openalex.org/W2012894470","https://openalex.org/W2008975884","https://openalex.org/W2028370431"],"abstract_inverted_index":{"P2Y(2)":[0,99,117,140],"and":[1,11,24,31,40,89,100,107,127,141,161,168],"P2Y(4)":[2,43,97,120,142,173],"receptors":[3,102],"are":[4,15],"G":[5],"protein-coupled":[6],"receptors,":[7],"activated":[8,116],"by":[9],"UTP":[10],"dinucleoside":[12],"tetraphosphates,":[13],"which":[14],"difficult":[16],"to":[17,79],"distinguish":[18],"pharmacologically":[19],"for":[20,95,125],"lack":[21],"of":[22,36,68,114,149,163],"potent":[23],"selective":[25],"ligands.":[26],"We":[27],"structurally":[28],"varied":[29],"phosphate":[30],"uracil":[32],"moieties":[33],"in":[34,46,50,58],"analogues":[35],"pyrimidine":[37],"nucleoside":[38],"5'-triphosphates":[39],"5'-tetraphosphate":[41,70],"esters.":[42],"receptor":[44,143],"potency":[45],"phospholipase":[47],"C":[48],"stimulation":[49],"transfected":[51],"1321N1":[52],"human":[53,96],"astrocytoma":[54],"cells":[55],"was":[56],"enhanced":[57],"N(4)-alkyloxycytidine":[59],"derivatives.":[60],"OH":[61],"groups":[62],"on":[63],"a":[64],"terminal":[65],"\u03b4-glucose":[66],"phosphoester":[67,112],"uridine":[69,165],"were":[71,130],"inverted":[72],"or":[73,77],"substituted":[74],"with":[75],"H":[76],"F":[78],"probe":[80],"H-bonding":[81],"effects.":[82],"N(4)-(Phenylpropoxy)-CTP":[83],"16":[84],"(MRS4062),":[85],"Up(4)-[1]3'-deoxy-3'-fluoroglucose":[86],"34":[87],"(MRS2927),":[88],"N(4)-(phenylethoxy)-CTP":[90],"15":[91],"exhibit":[92],"\u226510-fold":[93],"selectivity":[94],"over":[98],"P2Y(6)":[101],"(EC(50)":[103],"values":[104],"23,":[105],"62,":[106],"73":[108],"nM,":[109],"respectively).":[110],"\u03b4-3-Chlorophenyl":[111],"21":[113],"Up(4)":[115],"but":[118],"not":[119],"receptor.":[121],"Selected":[122],"nucleotides":[123],"tested":[124],"chemical":[126],"enzymatic":[128],"stability":[129,162],"much":[131],"more":[132],"stable":[133],"than":[134],"UTP.":[135],"Agonist":[136],"docking":[137],"at":[138,152],"CXCR4-based":[139],"models":[144],"indicated":[145],"greater":[146],"steric":[147],"tolerance":[148],"N(4)-phenylpropoxy":[150],"group":[151],"P2Y(4).":[153],"Thus,":[154],"distal":[155],"structural":[156],"changes":[157],"modulate":[158],"potency,":[159],"selectivity,":[160],"extended":[164],"tetraphosphate":[166],"derivatives,":[167],"we":[169],"report":[170],"the":[171],"first":[172],"receptor-selective":[174],"agonists.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}