{"id":"https://openalex.org/W2053768039","doi":"https://doi.org/10.1039/c0ob00657b","title":"Intramolecular Diels\u2013Alder chemistry of 4-vinylimidazoles","display_name":"Intramolecular Diels\u2013Alder chemistry of 4-vinylimidazoles","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2053768039","doi":"https://doi.org/10.1039/c0ob00657b","mag":"2053768039","pmid":"https://pubmed.ncbi.nlm.nih.gov/21350783"},"language":"en","primary_location":{"id":"doi:10.1039/c0ob00657b","doi":"https://doi.org/10.1039/c0ob00657b","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c0ob00657b","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100525012","display_name":"Yong He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong He","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011007459","display_name":"Pasupathy Krishnamoorthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pasupathy Krishnamoorthy","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079346990","display_name":"Heather M. Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather M. Lima","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067878097","display_name":"Yingzhong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingzhong Chen","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008106577","display_name":"Haiyan Wu","orcid":"https://orcid.org/0000-0002-0740-4900","observed_orcids":["https://orcid.org/0000-0002-0740-4900"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyan Wu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049723317","display_name":"Sivappa Rasapalli","orcid":"https://orcid.org/0000-0002-6397-6268","observed_orcids":["https://orcid.org/0000-0002-6397-6268"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasapalli Sivappa","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045832342","display_name":"H. V. Rasika Dias","orcid":"https://orcid.org/0000-0002-2362-1331","observed_orcids":["https://orcid.org/0000-0002-2362-1331"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. V. Rasika Dias","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074820584","display_name":"Carl J. Lovely","orcid":"https://orcid.org/0000-0001-7012-2001","observed_orcids":["https://orcid.org/0000-0001-7012-2001"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carl J. Lovely","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA","institution_ids":["https://openalex.org/I189196454"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The University of Texas at Arlington, Arlington, USA","institution_ids":["https://openalex.org/I189196454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045832342","https://openalex.org/A5074820584"],"corresponding_institution_ids":["https://openalex.org/I189196454"],"apc_list":null,"apc_paid":null,"fwci":1.122,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.74081994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"8","first_page":"2685","last_page":"2685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12893","display_name":"Organic Chemistry Cycloaddition Reactions","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12893","display_name":"Organic Chemistry Cycloaddition Reactions","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramolecular-diels-alder-reaction","display_name":"intramolecular Diels-Alder reaction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cycloaddition","display_name":"cycloaddition","score":0.781000018119812},{"id":"https://openalex.org/keywords/protecting-groups","display_name":"protecting groups","score":0.7009999752044678},{"id":"https://openalex.org/keywords/dienophiles","display_name":"dienophiles","score":0.640999972820282},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pyrrole-imidazole-alkaloids","display_name":"pyrrole-imidazole alkaloids","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9517728090286255},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.9016218185424805},{"id":"https://openalex.org/C2779664164","wikidata":"https://www.wikidata.org/wiki/Q898648","display_name":"Cycloaddition","level":3,"score":0.7549631595611572},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.7214539051055908},{"id":"https://openalex.org/C2780874372","wikidata":"https://www.wikidata.org/wiki/Q328692","display_name":"Imidazole","level":2,"score":0.7163286805152893},{"id":"https://openalex.org/C2778733088","wikidata":"https://www.wikidata.org/wiki/Q192678","display_name":"Diene","level":3,"score":0.7162067890167236},{"id":"https://openalex.org/C2779400197","wikidata":"https://www.wikidata.org/wiki/Q242627","display_name":"Pyrrole","level":2,"score":0.565089225769043},{"id":"https://openalex.org/C2779940776","wikidata":"https://www.wikidata.org/wiki/Q375669","display_name":"Diels\u2013Alder reaction","level":3,"score":0.5317577123641968},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41878464818000793},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3570318818092346},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3339277505874634},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.14320474863052368},{"id":"https://openalex.org/C176933379","wikidata":"https://www.wikidata.org/wiki/Q131877","display_name":"Natural rubber","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003500","descriptor_name":"Cyclization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014753","descriptor_name":"Vinyl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c0ob00657b","doi":"https://doi.org/10.1039/c0ob00657b","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c0ob00657b","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},{"id":"pmid:21350783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21350783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8078619345","display_name":"Approaches to Bioactive Aminoimidazole Natural Products","funder_award_id":"R01GM065503","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W1905362641","https://openalex.org/W1964652596","https://openalex.org/W1974130722","https://openalex.org/W1975288130","https://openalex.org/W1981308166","https://openalex.org/W1986795310","https://openalex.org/W1994273205","https://openalex.org/W1994871266","https://openalex.org/W1995706277","https://openalex.org/W1997085899","https://openalex.org/W1997802714","https://openalex.org/W1998926896","https://openalex.org/W2000374578","https://openalex.org/W2002804752","https://openalex.org/W2003701335","https://openalex.org/W2004845353","https://openalex.org/W2005388938","https://openalex.org/W2005549460","https://openalex.org/W2007259230","https://openalex.org/W2008054722","https://openalex.org/W2013663628","https://openalex.org/W2017761489","https://openalex.org/W2025005983","https://openalex.org/W2025576102","https://openalex.org/W2025613912","https://openalex.org/W2028093561","https://openalex.org/W2031342779","https://openalex.org/W2033721273","https://openalex.org/W2034534614","https://openalex.org/W2035770555","https://openalex.org/W2038739450","https://openalex.org/W2042205247","https://openalex.org/W2042318257","https://openalex.org/W2043759162","https://openalex.org/W2047187929","https://openalex.org/W2058441883","https://openalex.org/W2060817017","https://openalex.org/W2067748152","https://openalex.org/W2067866660","https://openalex.org/W2067872683","https://openalex.org/W2069317185","https://openalex.org/W2071402725","https://openalex.org/W2076045168","https://openalex.org/W2076183798","https://openalex.org/W2076328278","https://openalex.org/W2081850949","https://openalex.org/W2084028214","https://openalex.org/W2088714247","https://openalex.org/W2092595111","https://openalex.org/W2096827609","https://openalex.org/W2098601070","https://openalex.org/W2100049908","https://openalex.org/W2100793284","https://openalex.org/W2106882567","https://openalex.org/W2107494318","https://openalex.org/W2114217961","https://openalex.org/W2116714634","https://openalex.org/W2120547359","https://openalex.org/W2127339028","https://openalex.org/W2127971026","https://openalex.org/W2132819328","https://openalex.org/W2140905597","https://openalex.org/W2143518338","https://openalex.org/W2153666319","https://openalex.org/W2155477670","https://openalex.org/W2161998264","https://openalex.org/W2162202010","https://openalex.org/W2164241664","https://openalex.org/W2164895291","https://openalex.org/W2166424054","https://openalex.org/W2171221083","https://openalex.org/W2171344046","https://openalex.org/W2174022107","https://openalex.org/W2174997454","https://openalex.org/W2335166728","https://openalex.org/W2949747104","https://openalex.org/W2949749236","https://openalex.org/W2950034515","https://openalex.org/W2950807217","https://openalex.org/W2950973510","https://openalex.org/W2951632642","https://openalex.org/W2951878969","https://openalex.org/W2952039030","https://openalex.org/W2952530003","https://openalex.org/W2952606391","https://openalex.org/W2952725977","https://openalex.org/W2953082459","https://openalex.org/W2953297965","https://openalex.org/W4210820945","https://openalex.org/W4239914610","https://openalex.org/W4255594798"],"related_works":["https://openalex.org/W2953110122","https://openalex.org/W2051468859","https://openalex.org/W2069317185","https://openalex.org/W4395012477","https://openalex.org/W1997085899","https://openalex.org/W2890976930","https://openalex.org/W2895319696","https://openalex.org/W2013953759","https://openalex.org/W2110400877","https://openalex.org/W2951404662"],"abstract_inverted_index":{"An":[0],"investigation":[1],"of":[2,17,30,37,70,82,93],"4-vinylimidazoles":[3],"as":[4],"diene":[5],"components":[6],"in":[7,67],"the":[8,15,23,28,31,35,40,61,68,83,91],"intramolecular":[9],"Diels-Alder":[10],"reaction":[11],"is":[12],"described.":[13],"In":[14,58],"course":[16],"these":[18],"studies":[19],"several":[20],"parameters":[21],"affecting":[22],"cycloaddition":[24],"were":[25,49,63],"evaluated":[26],"including":[27],"nature":[29],"imidazole":[32],"protecting":[33],"group,":[34],"type":[36],"dienophile":[38],"and":[39],"linking":[41],"group.":[42],"These":[43],"investigations":[44],"established":[45],"that":[46],"amino":[47],"linkers":[48],"generally":[50],"more":[51],"effective":[52],"than":[53],"either":[54],"ethers":[55],"or":[56],"esters.":[57],"most":[59],"cases,":[60],"cycloadditions":[62],"highly":[64],"stereoselective,":[65],"resulting":[66],"formation":[69],"products":[71],"derived":[72],"from":[73],"an":[74],"anti":[75],"transition":[76],"state.":[77],"The":[78],"polysubstituted":[79],"tetrahydrobenzimidazole":[80],"core":[81],"pyrrole-imidazole":[84],"alkaloid":[85],"ageliferin":[86],"can":[87],"be":[88],"constructed":[89],"through":[90],"use":[92],"pseudo":[94],"dimeric":[95],"4-vinylimidazoles.":[96]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}