{"id":"https://openalex.org/W2053724811","doi":"https://doi.org/10.1152/japplphysiol.01545.2011","title":"Mechanical strain applied to human fibroblasts differentially regulates skeletal myoblast differentiation","display_name":"Mechanical strain applied to human fibroblasts differentially regulates skeletal myoblast differentiation","publication_year":2012,"publication_date":"2012-06-08","ids":{"openalex":"https://openalex.org/W2053724811","doi":"https://doi.org/10.1152/japplphysiol.01545.2011","mag":"2053724811","pmid":"https://pubmed.ncbi.nlm.nih.gov/22678963","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3426169"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.01545.2011","doi":"https://doi.org/10.1152/japplphysiol.01545.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01545.2011","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3426169","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103230703","display_name":"Michael R. Hicks","orcid":"https://orcid.org/0000-0002-1069-5075","observed_orcids":["https://orcid.org/0000-0002-1069-5075"]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Hicks","raw_affiliation_strings":["Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and","Molecular and Cellular Biology Graduate Programs, Arizona State University, Tempe, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and","institution_ids":["https://openalex.org/I4405259572"]},{"raw_affiliation_string":"Molecular and Cellular Biology Graduate Programs, Arizona State University, Tempe, Arizona","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112654765","display_name":"Thanh V. Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh V. Cao","raw_affiliation_strings":["Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106942267","display_name":"David H. Campbell","orcid":"https://orcid.org/0000-0003-0459-6326","observed_orcids":["https://orcid.org/0000-0003-0459-6326"]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Campbell","raw_affiliation_strings":["Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067795008","display_name":"Paul R. Standley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul R. Standley","raw_affiliation_strings":["Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, Arizona; and","institution_ids":["https://openalex.org/I4405259572"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067795008"],"corresponding_institution_ids":["https://openalex.org/I4405259572"],"apc_list":null,"apc_paid":null,"fwci":1.9948,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.86913653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"113","issue":"3","first_page":"465","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12712","display_name":"Myofascial pain diagnosis and treatment","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanical-strain","display_name":"mechanical strain","score":0.8820000290870667},{"id":"https://openalex.org/keywords/myofascial-release","display_name":"myofascial release","score":0.7590000033378601},{"id":"https://openalex.org/keywords/skeletal-myoblast-differentiation","display_name":"skeletal myoblast differentiation","score":0.781000018119812},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8050000071525574},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.953000009059906},{"id":"https://openalex.org/keywords/myotube-formation","display_name":"myotube formation","score":0.796999990940094},{"id":"https://openalex.org/keywords/myoblast-fusion","display_name":"myoblast fusion","score":0.753000020980835},{"id":"https://openalex.org/keywords/muscle-repair","display_name":"muscle repair","score":0.8270000219345093},{"id":"https://openalex.org/keywords/fibroblast-conditioned-medium","display_name":"fibroblast-conditioned medium","score":0.8399999737739563},{"id":"https://openalex.org/keywords/repetitive-strain-injury","display_name":"repetitive strain injury","score":0.699999988079071},{"id":"https://openalex.org/keywords/muscle-fascia","display_name":"muscle fascia","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.8691967725753784},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.7699269652366638},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.7606785893440247},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5827544927597046},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5107629299163818},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43397656083106995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43326056003570557},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.415127158164978},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3524642586708069},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33119767904281616},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3293270468711853},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3246919512748718},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23278501629829407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1634644865989685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12052786350250244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08657893538475037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024510","descriptor_name":"Muscle Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032448","descriptor_name":"Myoblasts, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032448","descriptor_name":"Myoblasts, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1152/japplphysiol.01545.2011","doi":"https://doi.org/10.1152/japplphysiol.01545.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01545.2011","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2722043","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3426169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:22678963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22678963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3426169","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3426169/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Appl Physiol (1985)","raw_type":"Text"},{"id":"mag:2188636500","doi":null,"is_oa":false,"landing_page_url":"https://jap.physiology.org/content/jap/113/3/465.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2722043","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3426169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1498464686","https://openalex.org/W1545253695","https://openalex.org/W1578400912","https://openalex.org/W1724968739","https://openalex.org/W1783309840","https://openalex.org/W1935013899","https://openalex.org/W1973902872","https://openalex.org/W1976440852","https://openalex.org/W1980776688","https://openalex.org/W1987020227","https://openalex.org/W1992043437","https://openalex.org/W1993150863","https://openalex.org/W1993646913","https://openalex.org/W1997149085","https://openalex.org/W1997971331","https://openalex.org/W1999902156","https://openalex.org/W2000142739","https://openalex.org/W2003457216","https://openalex.org/W2006021884","https://openalex.org/W2016060556","https://openalex.org/W2017429680","https://openalex.org/W2019989758","https://openalex.org/W2028530715","https://openalex.org/W2030498819","https://openalex.org/W2040213289","https://openalex.org/W2045218007","https://openalex.org/W2051434891","https://openalex.org/W2056975747","https://openalex.org/W2061353791","https://openalex.org/W2071445433","https://openalex.org/W2077928544","https://openalex.org/W2094708458","https://openalex.org/W2097408175","https://openalex.org/W2103488083","https://openalex.org/W2122641338","https://openalex.org/W2127881034","https://openalex.org/W2131466509","https://openalex.org/W2146857824","https://openalex.org/W2149631937","https://openalex.org/W2152798429","https://openalex.org/W2154362475","https://openalex.org/W2158111621","https://openalex.org/W2167878004","https://openalex.org/W2170313716","https://openalex.org/W2223742570","https://openalex.org/W2274186421","https://openalex.org/W2320475555","https://openalex.org/W2413873480","https://openalex.org/W3149218156","https://openalex.org/W4231286368"],"related_works":["https://openalex.org/W2144274867","https://openalex.org/W7015790981","https://openalex.org/W181533094","https://openalex.org/W2188636500","https://openalex.org/W2945475559","https://openalex.org/W2529356848","https://openalex.org/W2086670943","https://openalex.org/W2094648414","https://openalex.org/W2949916603","https://openalex.org/W1973221020"],"abstract_inverted_index":{"Cyclic":[0],"short-duration":[1],"stretches":[2],"(CSDS)":[3],"such":[4],"as":[5,139],"those":[6],"resulting":[7],"from":[8],"repetitive":[9,285],"motion":[10],"strain":[11,97,236,274,286],"increase":[12,223],"the":[13,117],"risk":[14],"of":[15,106,119,176,269,299],"musculoskeletal":[16],"injury.":[17,39],"Myofascial":[18],"release":[19,283],"is":[20,308],"a":[21,140],"common":[22],"technique":[23],"used":[24,84],"by":[25,155,207,212],"clinicians":[26],"that":[27,65,262,281],"applies":[28,96],"an":[29],"acyclic":[30],"long-duration":[31],"stretch":[32],"(ALDS)":[33],"to":[34,37,42,55,68,85,89,98,110,194,244],"muscle":[35,47,61,294],"fascia":[36,48],"repair":[38,295],"When":[40],"subjected":[41,67],"mechanical":[43],"strain,":[44],"fibroblasts":[45,66,99,177,195],"within":[46,172],"secrete":[49,259],"IL-6,":[50,120],"which":[51],"has":[52],"been":[53],"shown":[54],"induce":[56,72,90,245],"myoblast":[57,73,91,123,241,270,288],"differentiation,":[58,305],"essential":[59],"for":[60,104,158],"repair.":[62],"We":[63],"hypothesize":[64],"ALDS":[69,201],"following":[70,202],"CSDS":[71,192,203,215],"differentiation":[74,108,159,234,250,289],"through":[75],"IL-6.":[76],"Fibroblast":[77],"conditioned":[78,180],"media":[79,181],"and":[80,129,153,168,178,209,279,290],"fibroblast-myoblast":[81],"cocultures":[82,130],"were":[83,150],"test":[86],"fibroblasts'":[87],"ability":[88],"differentiation.":[92,246,271],"The":[93,174],"coculture":[94,222,253,302],"system":[95],"only":[100],"but":[101,310],"still":[102],"allows":[103],"diffusion":[105],"potential":[107],"mediators":[109,261],"unstrained":[111],"myoblasts":[112,137],"on":[113,266],"coverslips.":[114],"To":[115],"determine":[116],"role":[118],"we":[121],"utilized":[122],"unicultures":[124],"\u00b1":[125,131],"IL-6":[126,224,227,239,300],"(0-100":[127],"ng/ml)":[128],"\u03b1-IL-6":[132,248],"(0-200":[133],"\u03bcg/ml).":[134],"Untreated":[135],"uniculture":[136,242],"served":[138],"negative":[141],"control.":[142],"After":[143],"96":[144],"h,":[145],"coverslips":[146],"(n":[147],"=":[148],"6-21)":[149],"microscopically":[151],"analyzed":[152],"quantified":[154],"blinded":[156],"observer":[157],"endpoints:":[160],"myotubes":[161],"per":[162],"square":[163],"millimeter":[164],"(>3":[165],"nuclei/cell),":[166],"nuclei/myotube,":[167],"fusion":[169,210],"efficiency":[170,211],"(%nuclei":[171],"myotubes).":[173],"presence":[175],"fibroblast":[179],"significantly":[182,303],"enhanced":[183,233],"myotube":[184,205],"number":[185,206],"(P":[186,217,255],"<":[187,218,256],"0.05).":[188,219,257],"However,":[189,247],"in":[190,221,240,251,296,301,313],"coculture,":[191],"applied":[193],"did":[196,229],"not":[197,230,311],"reproduce":[198],"this":[199,314],"effect.":[200],"increased":[204],"78%":[208],"96%":[213],"vs.":[214],"alone":[216],"Fibroblasts":[220,258],"secretion;":[225],"however,":[226],"secretion":[228],"correlate":[231],"with":[232],"among":[235],"groups.":[237],"Exogenous":[238],"failed":[243],"attenuated":[249],"all":[252],"groups":[254],"soluble":[260],"have":[263],"profound":[264],"effects":[265],"several":[267],"measures":[268],"Specific":[272],"biophysical":[273],"patterns":[275],"modify":[276],"these":[277],"outcomes,":[278],"suggest":[280],"myofascial":[282],"after":[284],"increases":[287],"thus":[291],"may":[292],"improve":[293],"vivo.":[297],"Neutralization":[298],"reduced":[304],"suggesting":[306],"fibroblast-IL-6":[307],"necessary":[309],"sufficient":[312],"process.":[315]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}