{"id":"https://openalex.org/W2053689107","doi":"https://doi.org/10.1166/jnn.2012.6163","title":"Colloidal Platinum in Hydrogen-Rich Water Exhibits Radical-Scavenging Activity and Improves Blood Fluidity","display_name":"Colloidal Platinum in Hydrogen-Rich Water Exhibits Radical-Scavenging Activity and Improves Blood Fluidity","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2053689107","doi":"https://doi.org/10.1166/jnn.2012.6163","mag":"2053689107","pmid":"https://pubmed.ncbi.nlm.nih.gov/22852342"},"language":"en","primary_location":{"id":"doi:10.1166/jnn.2012.6163","doi":"https://doi.org/10.1166/jnn.2012.6163","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jnn.2012.6163","pdf_url":null,"source":{"id":"https://openalex.org/S133947007","display_name":"Journal of Nanoscience and Nanotechnology","issn_l":"1533-4880","issn":["1533-4880","1533-4899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanoscience and Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047547356","display_name":"Shinya Kato","orcid":"https://orcid.org/0000-0002-7199-3105","observed_orcids":["https://orcid.org/0000-0002-7199-3105"]},"institutions":[{"id":"https://openalex.org/I122146667","display_name":"Prefectural University of Hiroshima","ror":"https://ror.org/0059h1f24","country_code":"JP","type":"education","lineage":["https://openalex.org/I122146667","https://openalex.org/I4405287296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Kato","raw_affiliation_strings":["Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Nanatsuka 562, Shobara, Hiroshima 727-0023, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Nanatsuka 562, Shobara, Hiroshima 727-0023, Japan","institution_ids":["https://openalex.org/I122146667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038151479","display_name":"Ryoji Hokama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryoji Hokama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026944064","display_name":"Hajime Okayasu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajime Okayasu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025251474","display_name":"Yasukazu Saitoh","orcid":"https://orcid.org/0000-0002-6288-7634","observed_orcids":["https://orcid.org/0000-0002-6288-7634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasukazu Saitoh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000482694","display_name":"Keizou Iwai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keizou Iwai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075797192","display_name":"Nobuhiko Miwa","orcid":"https://orcid.org/0000-0003-0136-5952","observed_orcids":["https://orcid.org/0000-0003-0136-5952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuhiko Miwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9768,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.78179815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"5","first_page":"4019","last_page":"4027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14488","display_name":"Chemical and Physical Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colloidal-platinum","display_name":"colloidal platinum","score":0.9760000109672546},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hydrogen-rich-water","display_name":"hydrogen-rich water","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.953000009059906},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.8939999938011169},{"id":"https://openalex.org/keywords/blood-fluidity","display_name":"blood fluidity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/hemagglutination","display_name":"hemagglutination","score":0.8740000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8700000047683716},{"id":"https://openalex.org/keywords/erythrocyte-membrane-damage","display_name":"erythrocyte membrane damage","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hemorheology","display_name":"hemorheology","score":0.5270000100135803},{"id":"https://openalex.org/keywords/red-blood-cell-aggregation","display_name":"erythrocyte aggregation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/horse-blood","display_name":"horse blood","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C59789625","wikidata":"https://www.wikidata.org/wiki/Q181780","display_name":"Colloid","level":2,"score":0.7057897448539734},{"id":"https://openalex.org/C2780077769","wikidata":"https://www.wikidata.org/wiki/Q413433","display_name":"Polyvinylpyrrolidone","level":2,"score":0.6264685392379761},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5373498201370239},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.5250111222267151},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.492801696062088},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.42836278676986694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33464211225509644},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.160660058259964},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1335563063621521}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003102","descriptor_name":"Colloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003102","descriptor_name":"Colloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010984","descriptor_name":"Platinum","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010984","descriptor_name":"Platinum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1166/jnn.2012.6163","doi":"https://doi.org/10.1166/jnn.2012.6163","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jnn.2012.6163","pdf_url":null,"source":{"id":"https://openalex.org/S133947007","display_name":"Journal of Nanoscience and Nanotechnology","issn_l":"1533-4880","issn":["1533-4880","1533-4899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanoscience and Nanotechnology","raw_type":"journal-article"},{"id":"pmid:22852342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22852342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nanoscience and nanotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005996210","https://openalex.org/W2112859398","https://openalex.org/W1648056410","https://openalex.org/W4387099614","https://openalex.org/W2028588054","https://openalex.org/W2011222049","https://openalex.org/W2588994355","https://openalex.org/W2020540043","https://openalex.org/W3088161432","https://openalex.org/W2407798013"],"abstract_inverted_index":{"The":[0,100,274],"'colloidal":[1],"platinum'":[2],"stabilized":[3],"with":[4,60,115,140,171,201,227],"polyvinylpyrrolidone":[5],"(Pt/PVP-colloid)":[6],"was":[7,104,110,218],"dispersed":[8],"in":[9,37,65,79,134,144,152,243,261,269,287],"hydrogen-rich":[10],"water":[11,23],"(HW;":[12],"hydrogen":[13],"concentration,":[14],"0.82":[15],"ppm;":[16],"oxidation-reduction":[17],"potential,":[18],"-583":[19],"mV)":[20],"or":[21,39,67,77,117,125,146,161,177,245,251,271],"regular":[22],"(RW;":[24],"<0.01":[25],"ppm,":[26],"+218":[27],"mV).":[28],"And":[29],"we":[30],"evaluated":[31],"the":[32,61,69,82,132,148,153,166,198,213,224,232,281],"antioxidant":[33,283],"activity":[34,284],"of":[35,48,71,168,185,208,215,234,259,267,285],"Pt/PVP-colloid":[36,64,143,242,260,268],"HW":[38,89,228,246,262],"RW":[40,66,116,145,244,270],"on":[41,197,295],"1,1-diphenyl-2-picrylhydrazyl":[42],"(DPPH)":[43],"radical":[44],"scavenging":[45],"and":[46,119,165,203,212,256],"improvement":[47],"blood":[49,149,226],"fluidity":[50],"under":[51],"2,2'-azobis":[52],"(2-amidinopropane)":[53],"dihydrochloride":[54],"(AAPH)-induced":[55],"oxidative":[56,108],"stress.":[57],"When":[58,138,222],"applied":[59],"0.25-0.5":[62],"ppm":[63,142,241],"HW,":[68,118,147,288],"level":[70,83],"DPPH":[72],"radicals":[73],"decreased":[74,155,174,231,247],"to":[75,81,106,157,175,220,237,249,265,280,293],"77.5-59.6%":[76],"16.1-5.6%,":[78],"contrast":[80],"as":[84,86,92],"high":[85],"81.3%":[87],"for":[88,112,129,182],"alone,":[90],"respectively,":[91,179],"measured":[93],"by":[94],"an":[95],"electron":[96,189],"spin":[97],"resonance":[98],"method.":[99],"horse":[101,225],"blood,":[102],"which":[103,289],"subjected":[105],"AAPH-induced":[107],"stress,":[109],"incubated":[111],"24":[113],"hr":[114],"thereafter":[120],"required":[121],"13.7":[122],"sec":[123,127,159,163],"(100%)":[124],"5.7":[126],"(42.3%)":[128],"passing":[130],"through":[131],"micro-channels":[133,154,169],"a":[135],"rheology":[136],"equipment.":[137],"treated":[139,223],"0.5-1.0":[141],"passage":[150],"time":[151],"dose-dependently":[156],"9.7-7.3":[158],"(71.6-53.8%)":[160],"4.3-1.3":[162],"(32.8-10.3%),":[164],"rate":[167,214,233],"clogged":[170],"erythrocyte":[172,216,235],"aggregates":[173],"23.8-21.0%":[176],"15.8-9.8%,":[178],"from":[180],"42.8%":[181],"no":[183],"addition":[184],"Pt/PVP.":[186],"By":[187],"scanning":[188],"microscopy,":[190],"AAPH-treated":[191],"erythrocytes":[192],"lost":[193],"intact":[194],"surface":[195],"morphology":[196],"membrane":[199],"together":[200],"protrusions":[202],"without":[204],"hollows,":[205],"being":[206],"indicative":[207],"impaired":[209],"transforming":[210],"ability,":[211],"agglutination":[217,236],"increased":[219],"46.2%.":[221],"alone":[229],"significantly":[230],"29.6%,":[238],"whereas":[239],"1.0":[240],"it":[248],"24.1%":[250],"21.1%,":[252],"respectively.":[253],"Thus,":[254],"DPPH-radical-scavenging":[255],"erythrocyte-protecting":[257],"effects":[258],"were":[263],"superior":[264],"those":[266],"Pt/PVP-free":[272],"HW.":[273],"results":[275],"could":[276],"be":[277,291],"mainly":[278],"attributed":[279],"enhanced":[282],"Pt/PVP":[286],"may":[290],"due":[292],"captured-hydrogen":[294],"platinum.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}