{"id":"https://openalex.org/W2053666022","doi":"https://doi.org/10.1016/0168-1656(96)01524-6","title":"Improvement of the production of subtilisin Carlsberg alkaline protease by Bacillus licheniformis by on-line process monitoring and control in a stirred tank reactor","display_name":"Improvement of the production of subtilisin Carlsberg alkaline protease by Bacillus licheniformis by on-line process monitoring and control in a stirred tank reactor","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2053666022","doi":"https://doi.org/10.1016/0168-1656(96)01524-6","mag":"2053666022"},"language":"en","primary_location":{"id":"doi:10.1016/0168-1656(96)01524-6","doi":"https://doi.org/10.1016/0168-1656(96)01524-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-1656(96)01524-6","pdf_url":null,"source":{"id":"https://openalex.org/S182099265","display_name":"Journal of Biotechnology","issn_l":"0168-1656","issn":["0168-1656","1873-4863"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000263597","display_name":"Anton B. v. Putten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.B. Van Putten","raw_affiliation_strings":["Fermentation Pilot Plant, Novo Nordisk A/S, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Pilot Plant, Novo Nordisk A/S, Hannover, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084453626","display_name":"Folker Spitzenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Spitzenberger","raw_affiliation_strings":["Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076190861","display_name":"Gerlinde Kretzmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Kretzmer","raw_affiliation_strings":["Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050403354","display_name":"Bernd Hitzmann","orcid":"https://orcid.org/0000-0001-7762-7977","observed_orcids":["https://orcid.org/0000-0001-7762-7977"]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Hitzmann","raw_affiliation_strings":["Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028397219","display_name":"Michael Dors","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Dors","raw_affiliation_strings":["Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088074076","display_name":"Rimvydas Simutis","orcid":"https://orcid.org/0000-0002-3114-3130","observed_orcids":["https://orcid.org/0000-0002-3114-3130"]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Simutis","raw_affiliation_strings":["Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110245730","display_name":"K. Sch\u00fcgerl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"K. Sch\u00fcgerl","raw_affiliation_strings":["Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Technical Chemistry of the University of Hannover, Callinstr. 3, D-30167 Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110245730"],"corresponding_institution_ids":["https://openalex.org/I114112103"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":1.2169,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.74791742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"49","issue":"1-3","first_page":"83","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subtilisin-carlsberg","display_name":"subtilisin Carlsberg","score":0.9980000257492065},{"id":"https://openalex.org/keywords/alkaline-serine-protease","display_name":"alkaline serine protease","score":0.796999990940094},{"id":"https://openalex.org/keywords/bacillus-licheniformis","display_name":"Bacillus licheniformis","score":1.0},{"id":"https://openalex.org/keywords/online-process-monitoring","display_name":"real-time process monitoring","score":0.9070000052452087},{"id":"https://openalex.org/keywords/feedback-control","display_name":"feedback control","score":0.6159999966621399},{"id":"https://openalex.org/keywords/stirred-tank-reactor","display_name":"stirred tank reactor","score":0.7609999775886536},{"id":"https://openalex.org/keywords/flow-injection-analysis","display_name":"flow injection analysis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/starch-digestion","display_name":"starch hydrolysis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/glucose-feeding","display_name":"glucose feeding","score":0.5899999737739563},{"id":"https://openalex.org/keywords/ph-control","display_name":"pH control","score":0.718999981880188},{"id":"https://openalex.org/keywords/dissolved-oxygen-control","display_name":"dissolved oxygen control","score":0.8669999837875366},{"id":"https://openalex.org/keywords/off-gas-analysis","display_name":"off-gas analysis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/protease-production-optimization","display_name":"protease production optimization","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776527165","wikidata":"https://www.wikidata.org/wiki/Q2878356","display_name":"Bacillus licheniformis","level":4,"score":0.7902280688285828},{"id":"https://openalex.org/C2779811187","wikidata":"https://www.wikidata.org/wiki/Q423655","display_name":"Subtilisin","level":3,"score":0.7285503149032593},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.6724961996078491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6573489904403687},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6199025511741638},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.5672697424888611},{"id":"https://openalex.org/C2778197599","wikidata":"https://www.wikidata.org/wiki/Q170002","display_name":"Maltose","level":3,"score":0.5453275442123413},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5010735988616943},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.4695946276187897},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.4573255777359009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45097464323043823},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3283323645591736},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17679592967033386},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.12297707796096802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12062522768974304},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.1019432544708252},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0768192708492279},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0168-1656(96)01524-6","doi":"https://doi.org/10.1016/0168-1656(96)01524-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-1656(96)01524-6","pdf_url":null,"source":{"id":"https://openalex.org/S182099265","display_name":"Journal of Biotechnology","issn_l":"0168-1656","issn":["0168-1656","1873-4863"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biotechnology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W584893876","https://openalex.org/W1535272956","https://openalex.org/W1562724026","https://openalex.org/W1981023872","https://openalex.org/W1990734287","https://openalex.org/W1999439881","https://openalex.org/W2004373203","https://openalex.org/W2022510326","https://openalex.org/W2048315728","https://openalex.org/W2053460679","https://openalex.org/W2065770420","https://openalex.org/W2090598809","https://openalex.org/W2122875343","https://openalex.org/W2128635872","https://openalex.org/W2146272146","https://openalex.org/W2160824669","https://openalex.org/W2161104471","https://openalex.org/W2478161658","https://openalex.org/W2895514811"],"related_works":["https://openalex.org/W2004373203","https://openalex.org/W2160824669","https://openalex.org/W1981023872","https://openalex.org/W2074706250","https://openalex.org/W7099194201","https://openalex.org/W2057748407","https://openalex.org/W7066343669","https://openalex.org/W1995651807","https://openalex.org/W4375933513","https://openalex.org/W2147327847"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}