{"id":"https://openalex.org/W2053662475","doi":"https://doi.org/10.1371/journal.pone.0079775","title":"Prospective Validation of Immunological Infiltrate for Prediction of Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer \u2013 A Substudy of the Neoadjuvant GeparQuinto Trial","display_name":"Prospective Validation of Immunological Infiltrate for Prediction of Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer \u2013 A Substudy of the Neoadjuvant GeparQuinto Trial","publication_year":2013,"publication_date":"2013-12-02","ids":{"openalex":"https://openalex.org/W2053662475","doi":"https://doi.org/10.1371/journal.pone.0079775","mag":"2053662475","pmid":"https://pubmed.ncbi.nlm.nih.gov/24312450","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3846472"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0079775","doi":"https://doi.org/10.1371/journal.pone.0079775","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0079775","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2053662475"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pone.0079775","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030427888","display_name":"Yasmin Issa-Nummer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130803","display_name":"German Breast Group","ror":"https://ror.org/03c8hnh70","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210130803"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yasmin Issa-Nummer","raw_affiliation_strings":["German Breast Group, Neu-Isenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Breast Group, Neu-Isenburg, Germany","institution_ids":["https://openalex.org/I4210130803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052454978","display_name":"Silvia Darb\u2010Esfahani","orcid":"https://orcid.org/0000-0001-8508-5389","observed_orcids":["https://orcid.org/0000-0001-8508-5389"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia Darb-Esfahani","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087559224","display_name":"Sibylle Loibl","orcid":"https://orcid.org/0000-0001-6488-4958","observed_orcids":["https://orcid.org/0000-0001-6488-4958"]},"institutions":[{"id":"https://openalex.org/I4210130803","display_name":"German Breast Group","ror":"https://ror.org/03c8hnh70","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210130803"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sibylle Loibl","raw_affiliation_strings":["German Breast Group, Neu-Isenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Breast Group, Neu-Isenburg, Germany","institution_ids":["https://openalex.org/I4210130803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007647646","display_name":"Georg Kunz","orcid":"https://orcid.org/0009-0006-4081-1176","observed_orcids":["https://orcid.org/0009-0006-4081-1176"]},"institutions":[{"id":"https://openalex.org/I4210146953","display_name":"St.-Johannes-Hospital Dortmund","ror":"https://ror.org/04tf09b52","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210146953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg Kunz","raw_affiliation_strings":["Department of Gynecology and Obstetrics, St. Johannes Hospital, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, St. Johannes Hospital, Dortmund, Germany","institution_ids":["https://openalex.org/I4210146953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057181684","display_name":"Valentina Nekljudova","orcid":"https://orcid.org/0000-0002-2801-7387","observed_orcids":["https://orcid.org/0000-0002-2801-7387"]},"institutions":[{"id":"https://openalex.org/I4210130803","display_name":"German Breast Group","ror":"https://ror.org/03c8hnh70","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210130803"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valentina Nekljudova","raw_affiliation_strings":["German Breast Group, Neu-Isenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Breast Group, Neu-Isenburg, Germany","institution_ids":["https://openalex.org/I4210130803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003665481","display_name":"Iris Schrader","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iris Schrader","raw_affiliation_strings":["Frauenklinik Henriettenstiftung, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frauenklinik Henriettenstiftung, Hannover, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052578346","display_name":"Bruno Valentin Sinn","orcid":"https://orcid.org/0000-0002-1257-9799","observed_orcids":["https://orcid.org/0000-0002-1257-9799"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bruno Valentin Sinn","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111762622","display_name":"Hans-Ullrich Ulmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090715","display_name":"St\u00e4dtisches Klinikum Karlsruhe","ror":"https://ror.org/00agtat91","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210090715"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Ullrich Ulmer","raw_affiliation_strings":["Frauenklinik, St\u00e4dtisches Klinikum Karlsruhe, Karlsruhe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frauenklinik, St\u00e4dtisches Klinikum Karlsruhe, Karlsruhe, Germany","institution_ids":["https://openalex.org/I4210090715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018297283","display_name":"Ralf Kronenwett","orcid":"https://orcid.org/0000-0002-8494-6981","observed_orcids":["https://orcid.org/0000-0002-8494-6981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralf Kronenwett","raw_affiliation_strings":["Sividon Diagnostics GmbH, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sividon Diagnostics GmbH, Cologne, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002071285","display_name":"Marianne Just","orcid":"https://orcid.org/0009-0009-2504-7060","observed_orcids":["https://orcid.org/0009-0009-2504-7060","https://orcid.org/0009-0000-6366-9340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianne Just","raw_affiliation_strings":["Schwerpunktpraxis Bielefeld, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schwerpunktpraxis Bielefeld, Bielefeld, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021367756","display_name":"Thorsten K\u00fchn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117167","display_name":"Klinikum Esslingen","ror":"https://ror.org/02a2sfd38","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210117167"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten K\u00fchn","raw_affiliation_strings":["Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Klinikum Esslingen, Esslingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Klinikum Esslingen, Esslingen, Germany","institution_ids":["https://openalex.org/I4210117167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042166924","display_name":"Kurt Diebold","orcid":"https://orcid.org/0009-0005-3736-7265","observed_orcids":["https://orcid.org/0009-0005-3736-7265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kurt Diebold","raw_affiliation_strings":["Gemeinschaftspraxis f\u00fcr Pathologie Hamm, Hamm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gemeinschaftspraxis f\u00fcr Pathologie Hamm, Hamm, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003405177","display_name":"Michael Untch","orcid":"https://orcid.org/0000-0002-1233-1267","observed_orcids":["https://orcid.org/0000-0002-1233-1267"]},"institutions":[{"id":"https://openalex.org/I4210156283","display_name":"Helios Hospital Berlin-Buch","ror":"https://ror.org/05hgh1g19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940","https://openalex.org/I4210156283"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Untch","raw_affiliation_strings":["Breast Center, Helios-Klinikum Berlin-Buch, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center, Helios-Klinikum Berlin-Buch, Berlin, Germany","institution_ids":["https://openalex.org/I4210156283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034420549","display_name":"Frank Holms","orcid":"https://orcid.org/0000-0002-2672-9874","observed_orcids":["https://orcid.org/0000-0002-2672-9874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Holms","raw_affiliation_strings":["Gyn\u00e4kologie und Geburtshilfe, St. Barbara-Klinik Hamm-Heessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gyn\u00e4kologie und Geburtshilfe, St. Barbara-Klinik Hamm-Heessen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024741688","display_name":"Jens\u2010Uwe Blohmer","orcid":"https://orcid.org/0000-0002-7969-250X","observed_orcids":["https://orcid.org/0000-0002-7969-250X"]},"institutions":[{"id":"https://openalex.org/I4210109045","display_name":"Sankt Gertrauden Krankenhaus","ror":"https://ror.org/01p0ze617","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109045"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens-Uwe Blohmer","raw_affiliation_strings":["Breast Center, St. Gertrauden Krankenhaus Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center, St. Gertrauden Krankenhaus Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210109045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109278176","display_name":"J\u00f6rg-Olaf Habeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162138","display_name":"Klinikum Chemnitz","ror":"https://ror.org/04wkp4f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162138"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg-Olaf Habeck","raw_affiliation_strings":["Zentrum f\u00fcr Histopathologie Chemnitz, Chemnitz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum f\u00fcr Histopathologie Chemnitz, Chemnitz, Germany","institution_ids":["https://openalex.org/I4210162138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062227589","display_name":"Manfred Dietel","orcid":"https://orcid.org/0009-0001-4303-7837","observed_orcids":["https://orcid.org/0009-0001-4303-7837"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Dietel","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053845865","display_name":"Friedrich Overkamp","orcid":"https://orcid.org/0000-0002-9633-5205","observed_orcids":["https://orcid.org/0000-0002-9633-5205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Friedrich Overkamp","raw_affiliation_strings":["Oncologianova GmbH Recklinghausen, Recklinghausen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncologianova GmbH Recklinghausen, Recklinghausen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114004980","display_name":"Petra Krabisch","orcid":"https://orcid.org/0009-0001-1433-2693","observed_orcids":["https://orcid.org/0009-0001-1433-2693"]},"institutions":[{"id":"https://openalex.org/I4210162138","display_name":"Klinikum Chemnitz","ror":"https://ror.org/04wkp4f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162138"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Krabisch","raw_affiliation_strings":["Breast Center, Klinikum Chemnitz, Chemnitz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center, Klinikum Chemnitz, Chemnitz, Germany","institution_ids":["https://openalex.org/I4210162138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110911891","display_name":"G\u03cbnter von Minckwitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130803","display_name":"German Breast Group","ror":"https://ror.org/03c8hnh70","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210130803"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gunter von Minckwitz","raw_affiliation_strings":["German Breast Group, Neu-Isenburg, Germany","University Women's Hospital, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Breast Group, Neu-Isenburg, Germany","institution_ids":["https://openalex.org/I4210130803"]},{"raw_affiliation_string":"University Women's Hospital, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033698551","display_name":"Carsten Denkert","orcid":"https://orcid.org/0000-0002-2249-0982","observed_orcids":["https://orcid.org/0000-0002-2249-0982"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten Denkert","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5087559224"],"corresponding_institution_ids":["https://openalex.org/I4210130803"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":6.3754,"has_fulltext":true,"cited_by_count":232,"citation_normalized_percentile":{"value":0.97908423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"8","issue":"12","first_page":"e79775","last_page":"e79775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lymphocyte-predominant-breast-cancer","display_name":"lymphocyte-predominant breast cancer","score":0.8209999799728394},{"id":"https://openalex.org/keywords/intratumoral-lymphocytes","display_name":"intratumoral lymphocytes","score":0.921999990940094},{"id":"https://openalex.org/keywords/stromal-lymphocytes","display_name":"stromal lymphocytes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9120000004768372},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/anthracycline-taxane-chemotherapy","display_name":"anthracycline-taxane chemotherapy","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7664309740066528},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6913084983825684},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.6322956681251526},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.5945848226547241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.561944305896759},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.543472170829773},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5212712287902832},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.49387866258621216},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.49131837487220764},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4532356262207031},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36462023854255676},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3318023681640625},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.08985009789466858}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0079775","doi":"https://doi.org/10.1371/journal.pone.0079775","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0079775","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3846472","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3846472/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3846472/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2837521","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3846472","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24312450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24312450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.6755","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.6755","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6b/f6/pone.0079775.PMC3846472.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0079775","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079775","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:faa195c3a48443908de3f52402409581","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/faa195c3a48443908de3f52402409581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 12, p e79775 (2013)","raw_type":"article"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:32887","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:hebis:30:3-328874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0079775","doi":"https://doi.org/10.1371/journal.pone.0079775","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0079775","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1060360579","display_name":"Verbundprojekt: NEO-PREDICT - Subprojekt 1: Validierung von Protein- und RNA-Biomarkern aus zellul\u00e4ren Modellsystemen f\u00fcr die Pr\u00e4diktion des Ansprechens auf eine neoadjuvante Chemotherapie beim Mammakarzinom","funder_award_id":"01ES0725","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053662475.pdf","grobid_xml":"https://content.openalex.org/works/W2053662475.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1490524111","https://openalex.org/W1498187417","https://openalex.org/W1598843567","https://openalex.org/W1600186066","https://openalex.org/W1891141189","https://openalex.org/W1973091654","https://openalex.org/W1973855239","https://openalex.org/W1975401903","https://openalex.org/W1979379635","https://openalex.org/W1994625040","https://openalex.org/W1998068737","https://openalex.org/W2001498331","https://openalex.org/W2001646586","https://openalex.org/W2010671504","https://openalex.org/W2019182330","https://openalex.org/W2023980114","https://openalex.org/W2031576122","https://openalex.org/W2044253211","https://openalex.org/W2046972425","https://openalex.org/W2053122486","https://openalex.org/W2053934419","https://openalex.org/W2069372863","https://openalex.org/W2087179076","https://openalex.org/W2088160256","https://openalex.org/W2096151993","https://openalex.org/W2101654319","https://openalex.org/W2103724008","https://openalex.org/W2105459360","https://openalex.org/W2107894271","https://openalex.org/W2113242459","https://openalex.org/W2114043422","https://openalex.org/W2116576993","https://openalex.org/W2120338564","https://openalex.org/W2125396123","https://openalex.org/W2125789181","https://openalex.org/W2127267391","https://openalex.org/W2132516902","https://openalex.org/W2137074525","https://openalex.org/W2138600064","https://openalex.org/W2138734774","https://openalex.org/W2138968403","https://openalex.org/W2139510434","https://openalex.org/W2140633375","https://openalex.org/W2140654333","https://openalex.org/W2146146786","https://openalex.org/W2150633526","https://openalex.org/W2157058802","https://openalex.org/W2160117150","https://openalex.org/W2162929947","https://openalex.org/W2164540420","https://openalex.org/W2171481006"],"related_works":["https://openalex.org/W2157058802","https://openalex.org/W3033570524","https://openalex.org/W2334410833","https://openalex.org/W2135298509","https://openalex.org/W2590419781","https://openalex.org/W2044928979","https://openalex.org/W2981420512","https://openalex.org/W3166045426","https://openalex.org/W4301401003"],"abstract_inverted_index":{"INTRODUCTION:":[0],"We":[1],"have":[2,197,228],"recently":[3],"described":[4],"an":[5,201,205],"increased":[6,124,206,224,230],"lymphocytic":[7,234],"infiltration":[8,227],"rate":[9,126],"in":[10,54,145,170,179,200,209],"breast":[11,87,118,210,245],"carcinoma":[12],"tissue":[13,212],"is":[14,213,236],"a":[15,55,70,122,237],"significant":[16],"response":[17,41,97,216],"predictor":[18],"for":[19,40,143,168,215,241],"anthracycline/taxane-based":[20,43,218],"neoadjuvant":[21,74],"chemotherapy":[22],"(NACT).":[23],"The":[24,48,160,233],"aim":[25],"of":[26,57,65,72,112,127,162,193,244],"this":[27],"study":[28],"was":[29,51,165],"to":[30,42,130,217],"prospectively":[31,52,198],"validate":[32],"the":[33,66,73,105,109],"tumor-associated":[34],"lymphocyte":[35,226],"infiltrate":[36,50,208,235],"as":[37,83,85],"predictive":[38,167,214],"marker":[39],"NACT.":[44,219],"PATIENTS":[45],"AND":[46],"METHODS:":[47],"immunological":[49,207],"evaluated":[53,91],"total":[56],"313":[58],"core":[59,247],"biopsies":[60],"from":[61],"HER2":[62],"negative":[63],"patients":[64,132],"multicenter":[67],"PREDICT":[68],"study,":[69],"substudy":[71],"GeparQuinto":[75],"study.":[76],"Intratumoral":[77],"lymphocytes":[78,81,138,164],"(iTuLy),":[79],"stromal":[80,137,225],"(strLy)":[82],"well":[84],"lymphocyte-predominant":[86,117],"cancer":[88,119,246],"(LPBC)":[89,120],"were":[90,100,139],"by":[92],"histopathological":[93,242],"assessment.":[94],"Pathological":[95],"complete":[96],"(pCR)":[98],"rates":[99],"analyzed":[101],"and":[102,136,223],"compared":[103,129],"between":[104],"defined":[106],"subgroups":[107],"using":[108],"exact":[110],"test":[111],"Fisher.":[113],"RESULTS:":[114],"Patients":[115,220],"with":[116,221],"had":[121],"significantly":[123,140,166,229],"pCR":[125,144,169,231],"36.6%,":[128],"non-LPBC":[131],"(14.3%,":[133],"p<0.001).":[134],"LPBC":[135,222],"independent":[141,202],"predictors":[142],"multivariate":[146,180],"analysis":[147,183],"(LPBC:":[148],"OR":[149,155],"2.7,":[150],"p":[151,157,174,186],"=":[152,158,175,187],"0.003,":[153],"strLy:":[154],"1.2,":[156,173,185],"0.01).":[159],"amount":[161],"intratumoral":[163],"univariate":[171],"(OR":[172,184],"0.01)":[176],"but":[177],"not":[178],"logistic":[181],"regression":[182],"0.11).":[188],"CONCLUSION:":[189],"Confirming":[190],"previous":[191],"investigations":[192],"our":[194],"group,":[195],"we":[196],"validated":[199],"cohort":[203],"that":[204],"tumor":[211],"rates.":[232],"promising":[238],"additional":[239],"parameter":[240],"evaluation":[243],"biopsies.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":12}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
