{"id":"https://openalex.org/W2053655419","doi":"https://doi.org/10.1097/00000542-197201000-00002","title":"The Response of Brain Surface Pressure to Hypercapnic Hypoxia and Hyperventilation","display_name":"The Response of Brain Surface Pressure to Hypercapnic Hypoxia and Hyperventilation","publication_year":1972,"publication_date":"1972-01-01","ids":{"openalex":"https://openalex.org/W2053655419","doi":"https://doi.org/10.1097/00000542-197201000-00002","mag":"2053655419","pmid":"https://pubmed.ncbi.nlm.nih.gov/5006986"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-197201000-00002","doi":"https://doi.org/10.1097/00000542-197201000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-197201000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036674863","display_name":"Alfonso Schettini","orcid":"https://orcid.org/0009-0002-9664-0223","observed_orcids":["https://orcid.org/0009-0002-9664-0223"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Schettini","raw_affiliation_strings":["Assistant Professor, Department of Anesthesiology, University of Florida College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Anesthesiology, University of Florida College of Medicine","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L McKay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L McKay","raw_affiliation_strings":["Graduate student, Brooklyn Polytechnic Institute, Brooklyn, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate student, Brooklyn Polytechnic Institute, Brooklyn, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081444653","display_name":"Joseph Mahig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Mahig","raw_affiliation_strings":["Associate Professor, Department of Mechanical Engineering, University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Department of Mechanical Engineering, University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105986607","display_name":"Jerome H. Modell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Modell","raw_affiliation_strings":["Professor and Chairman, Department of Anesthesiology, University of Florida College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Chairman, Department of Anesthesiology, University of Florida College of Medicine","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7754,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89215398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"1","first_page":"4","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-pressure","display_name":"cerebrospinal fluid pressure","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hypercapnic-hypoxia","display_name":"hypercapnic hypoxia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hyperventilation","display_name":"hyperventilation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hypoventilation","display_name":"hypoventilation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2777449187","wikidata":"https://www.wikidata.org/wiki/Q575168","display_name":"Hyperventilation","level":2,"score":0.9376673698425293},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7258927226066589},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6913968324661255},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6747101545333862},{"id":"https://openalex.org/C2779594553","wikidata":"https://www.wikidata.org/wiki/Q1641494","display_name":"Hypoventilation","level":3,"score":0.6467506885528564},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6112738847732544},{"id":"https://openalex.org/C2994005214","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid pressure","level":3,"score":0.5479998588562012},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.46978726983070374},{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.45168501138687134},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.27871477603912354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23475372791290283},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.17586126923561096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10551723837852478},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.06687548756599426},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006985","descriptor_name":"Hyperventilation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006985","descriptor_name":"Hyperventilation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007427","descriptor_name":"Intracranial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008365","descriptor_name":"Manometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010102","descriptor_name":"Oxygen Inhalation Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-197201000-00002","doi":"https://doi.org/10.1097/00000542-197201000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-197201000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:5006986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5006986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2441537348","https://openalex.org/W2351610085","https://openalex.org/W2160026023","https://openalex.org/W2035437640","https://openalex.org/W2412236990","https://openalex.org/W1997707333","https://openalex.org/W2072798060","https://openalex.org/W1983460830","https://openalex.org/W2072181000","https://openalex.org/W203342848"],"abstract_inverted_index":{"Intracranial":[0],"pressures":[1,22,119],"(cisternal":[2],"cerebrospinal":[3,53],"fluid":[4,54],"and":[5,16,100,116],"brain":[6,62,95,117,129],"surface":[7,63,118],"pressures)":[8],"were":[9,47,79],"measured":[10],"in":[11],"nine":[12],"anesthetized":[13],"dogs":[14,46,78],"during":[15,97],"after":[17,25],"experimental":[18],"hypercapnic":[19,98],"hypoxia.":[20],"Both":[21],"increased":[23],"significantly":[24],"20":[26,35],"minutes":[27],"of":[28,84,93,107,111,141],"hypoventilation":[29],"with":[30,50],"the":[31,45,52,61,66,77,94,126,138,142],"hypoxic":[32],"mixture":[33],"(PaO2":[34],"\u00b1":[36,41],"7.3":[37],"torr;":[38],"PaCO2":[39],"87":[40],"7.9":[42],"torr).":[43],"When":[44],"subsequently":[48],"hyperventilated":[49],"oxygen,":[51],"pressure":[55,59,70,133,140],"rapidly":[56],"declined,":[57],"but":[58],"at":[60],"remained":[64],"twice":[65],"control":[67],"value.":[68],"This":[69],"dissociation":[71],"was":[72,123],"even":[73],"more":[74],"striking":[75],"when":[76],"then":[80],"given":[81],"an":[82,105],"infusion":[83],"distilled":[85],"water":[86],"intraveously.":[87],"These":[88],"findings":[89],"suggest":[90],"that":[91,121],"swelling":[92],"occurs":[96],"hypoxia":[99],"is":[101],"not":[102],"reversed":[103],"by":[104],"hour":[106],"hyperventilation.":[108],"The":[109],"lack":[110],"correlation":[112],"between":[113],"cisternal":[114],"CSF":[115,122,132],"suggests":[120],"displaced":[124],"from":[125],"cranium":[127],"while":[128],"volume":[130],"expanded.":[131],"did":[134],"not,":[135],"therefore,":[136],"reflect":[137],"actual":[139],"brain.":[143]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
