{"id":"https://openalex.org/W2053586497","doi":"https://doi.org/10.1006/cbir.1993.1021","title":"Thapsigargin, a Ca2+\u2010ATPase inhibitor, depletes the intracellular Ca2+ pool and induces apoptosis in human hepatoma cells.","display_name":"Thapsigargin, a Ca2+\u2010ATPase inhibitor, depletes the intracellular Ca2+ pool and induces apoptosis in human hepatoma cells.","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2053586497","doi":"https://doi.org/10.1006/cbir.1993.1021","mag":"2053586497","pmid":"https://pubmed.ncbi.nlm.nih.gov/8287027"},"language":"en","primary_location":{"id":"doi:10.1006/cbir.1993.1021","doi":"https://doi.org/10.1006/cbir.1993.1021","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cbir.1993.1021","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005721506","display_name":"Ayumi Tsukamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayumi Tsukamoto","raw_affiliation_strings":["First Department of Medicine, University of Tokyo, Japan","First Department of Medicine, The University of Tokyo 7-3-1, Hongo, Bunkyo-ku, Tokyo 113 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"First Department of Medicine, The University of Tokyo 7-3-1, Hongo, Bunkyo-ku, Tokyo 113 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113677973","display_name":"Yoshiyasu Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyasu Kaneko","raw_affiliation_strings":["First Department of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.1918,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.42007435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"17","issue":"10","first_page":"969","last_page":"970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.4758000075817108,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.4758000075817108,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.08669999986886978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":1.0},{"id":"https://openalex.org/keywords/intracellular-calcium-depletion","display_name":"intracellular calcium depletion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/human-hepatoma-cells","display_name":"human hepatoma cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.7330750226974487},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5031318068504333},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4231695830821991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35735222697257996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17017871141433716}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019284","descriptor_name":"Thapsigargin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/cbir.1993.1021","doi":"https://doi.org/10.1006/cbir.1993.1021","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cbir.1993.1021","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},{"id":"pmid:8287027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8287027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075242716","https://openalex.org/W1596254568","https://openalex.org/W1967057358","https://openalex.org/W3032132778","https://openalex.org/W1548027699","https://openalex.org/W2063535351","https://openalex.org/W156885574","https://openalex.org/W2054829274","https://openalex.org/W2110767869","https://openalex.org/W2007450837"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
