{"id":"https://openalex.org/W2053554844","doi":"https://doi.org/10.1248/bpb1978.15.597","title":"Inhibition of Salvage Synthesis of Nucleic Acid by Adenosine 3',5'-Cyclic Decylphosphoramidate in Mastocytoma P-815 Cells.","display_name":"Inhibition of Salvage Synthesis of Nucleic Acid by Adenosine 3',5'-Cyclic Decylphosphoramidate in Mastocytoma P-815 Cells.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2053554844","doi":"https://doi.org/10.1248/bpb1978.15.597","mag":"2053554844","pmid":"https://pubmed.ncbi.nlm.nih.gov/1337357"},"language":"en","primary_location":{"id":"doi:10.1248/bpb1978.15.597","doi":"https://doi.org/10.1248/bpb1978.15.597","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb1978.15.597","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1978/15/10/15_10_597/_pdf","source":{"id":"https://openalex.org/S2754333470","display_name":"Journal of Pharmacobio-Dynamics","issn_l":"0386-846X","issn":["0386-846X","1881-1353"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacobio-Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb1978/15/10/15_10_597/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100714640","display_name":"Makoto Saito","orcid":"https://orcid.org/0000-0002-0778-3410","observed_orcids":["https://orcid.org/0000-0002-0778-3410"]},"institutions":[{"id":"https://openalex.org/I4210091546","display_name":"Noda Institute for Scientific Research","ror":"https://ror.org/00105n552","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210091546"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto SAITO","raw_affiliation_strings":["Noda Institute for Scientific Research, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Noda Institute for Scientific Research, Chiba, Japan","institution_ids":["https://openalex.org/I4210091546"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ayako NASU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayako NASU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108268441","display_name":"Shigehiro Kataoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigehiro KATAOKA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110351490","display_name":"Nobuyuki Yamaji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuyuki YAMAJI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036189941","display_name":"Atsushi Ichikawa","orcid":"https://orcid.org/0009-0000-2175-2963","observed_orcids":["https://orcid.org/0009-0000-2175-2963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi ICHIKAWA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1117,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34172798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"10","first_page":"597","last_page":"604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymidine-kinase-inhibition","display_name":"thymidine kinase inhibition","score":0.8579999804496765},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.746999979019165},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nucleotide-incorporation","display_name":"nucleotide incorporation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.5899999737739563},{"id":"https://openalex.org/keywords/phosphodiesterase-resistance","display_name":"phosphodiesterase resistance","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7427061200141907},{"id":"https://openalex.org/C194101687","wikidata":"https://www.wikidata.org/wiki/Q583813","display_name":"Nucleotide salvage","level":4,"score":0.7391626834869385},{"id":"https://openalex.org/C2778930412","wikidata":"https://www.wikidata.org/wiki/Q6785569","display_name":"Mastocytoma","level":3,"score":0.7364324331283569},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6422755718231201},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.6412477493286133},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5761959552764893},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5534857511520386},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.5485981702804565},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.5246046781539917},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.480074942111969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4702531099319458},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.429138720035553},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4159294366836548},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40053409337997437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36573362350463867},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3609352707862854},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34493309259414673},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33751630783081055},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07412794232368469},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007042","descriptor_name":"Hypoxanthines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012515","descriptor_name":"Mast-Cell Sarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013942","descriptor_name":"Thymine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb1978.15.597","doi":"https://doi.org/10.1248/bpb1978.15.597","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb1978.15.597","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1978/15/10/15_10_597/_pdf","source":{"id":"https://openalex.org/S2754333470","display_name":"Journal of Pharmacobio-Dynamics","issn_l":"0386-846X","issn":["0386-846X","1881-1353"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacobio-Dynamics","raw_type":"journal-article"},{"id":"pmid:1337357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1337357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacobio-dynamics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb1978.15.597","doi":"https://doi.org/10.1248/bpb1978.15.597","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb1978.15.597","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1978/15/10/15_10_597/_pdf","source":{"id":"https://openalex.org/S2754333470","display_name":"Journal of Pharmacobio-Dynamics","issn_l":"0386-846X","issn":["0386-846X","1881-1353"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacobio-Dynamics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053554844.pdf","grobid_xml":"https://content.openalex.org/works/W2053554844.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1484406349","https://openalex.org/W1533810698","https://openalex.org/W1775749144","https://openalex.org/W1963828781","https://openalex.org/W1965851946","https://openalex.org/W1967337291","https://openalex.org/W1988798723","https://openalex.org/W1989957427","https://openalex.org/W1992565528","https://openalex.org/W1994231412","https://openalex.org/W1997212665","https://openalex.org/W2002080915","https://openalex.org/W2007317755","https://openalex.org/W2010909086","https://openalex.org/W2011375554","https://openalex.org/W2028309431","https://openalex.org/W2048596513","https://openalex.org/W2059086996","https://openalex.org/W2064300974","https://openalex.org/W2065341946","https://openalex.org/W2076355513","https://openalex.org/W2078972772","https://openalex.org/W2091183478","https://openalex.org/W2119263245","https://openalex.org/W2138960374","https://openalex.org/W2147806404","https://openalex.org/W2330689915","https://openalex.org/W2405535109","https://openalex.org/W2470547255"],"related_works":["https://openalex.org/W2064300974","https://openalex.org/W2074578290","https://openalex.org/W2045237327","https://openalex.org/W2330689915","https://openalex.org/W2062646366","https://openalex.org/W2426590730","https://openalex.org/W2063471948","https://openalex.org/W2002343279","https://openalex.org/W2057805280","https://openalex.org/W4242778915"],"abstract_inverted_index":{"Constant":[0],"exposure":[1],"of":[2,23,36,54,57,66,75,90,104,168,182],"mastocytoma":[3],"P-815":[4],"cells":[5,43,110],"to":[6,14,20,29],"adenosine":[7],"3',5'-cyclic":[8],"decylphosphoramidate":[9],"(1),":[10],"which":[11,177],"is":[12,149],"permeable":[13],"the":[15,21,34,42,55,73,87,129,156,165,180],"cell":[16,39,157,183],"membrane":[17],"and":[18,38,64,93,170],"resistant":[19],"action":[22],"phosphodiesterase,":[24],"caused":[25,51],"a":[26,98],"dose-dependent":[27],"(1":[28],"50":[30],"microM)":[31],"inhibition":[32,53,181],"in":[33,101,109,179],"synthesis":[35,74,89,103,167],"DNA":[37],"proliferation.":[40],"Pretreating":[41],"with":[44,112],"compound":[45,83,113,132,152],"1":[46,84,114,133,153],"(20":[47],"microM,":[48],"4":[49,119],"h)":[50],"considerable":[52],"incorporation":[56],"[3H]thymidine":[58],"([3H]TdR)":[59],"into":[60,68],"[3H]deoxythymidine":[61],"5'-triphosphate":[62],"([3H]dTTP)":[63],"that":[65,82,151],"[14C]hypoxanthine":[67],"nucleic":[69,94,171],"acid,":[70],"but":[71],"not":[72],"[14C]dTTP":[76],"from":[77,141,145],"[U-14C]aspartate.":[78],"These":[79],"results":[80,178],"indicate":[81],"preferentially":[85],"inhibits":[86,164],"salvage":[88,102,166],"intracellular":[91],"nucleotides":[92,169],"acids.":[95],"Thymidine":[96],"kinase,":[97,162,176],"key":[99],"enzyme":[100],"nucleotides,":[105],"was":[106],"almost":[107],"undetectable":[108],"pretreated":[111],"at":[115,122],"20":[116],"microM":[117,124],"for":[118,125],"h":[120],"or":[121],"5":[123],"15":[126],"h.":[127],"On":[128],"other":[130],"hand,":[131],"activated":[134],"partially":[135],"purified":[136],"cAMP-dependent":[137,160],"protein":[138,161],"kinase":[139],"A":[140],"bovine":[142],"heart.":[143],"Judging":[144],"these":[146],"observations,":[147],"it":[148],"likely":[150],"readily":[154],"permeates":[155],"membrane,":[158],"activates":[159],"then":[163],"acids":[172],"by":[173],"inhibiting":[174],"thymidine":[175],"growth.":[184]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}