{"id":"https://openalex.org/W2053544705","doi":"https://doi.org/10.1139/o70-079","title":"Biotin and glucose metabolism","display_name":"Biotin and glucose metabolism","publication_year":1970,"publication_date":"1970-04-01","ids":{"openalex":"https://openalex.org/W2053544705","doi":"https://doi.org/10.1139/o70-079","mag":"2053544705","pmid":"https://pubmed.ncbi.nlm.nih.gov/4246111"},"language":"en","primary_location":{"id":"doi:10.1139/o70-079","doi":"https://doi.org/10.1139/o70-079","is_oa":false,"landing_page_url":"https://doi.org/10.1139/o70-079","pdf_url":null,"source":{"id":"https://openalex.org/S4210188051","display_name":"Canadian Journal of Biochemistry","issn_l":"0008-4018","issn":["0008-4018"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111525925","display_name":"K. Dakshinamurti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Dakshinamurti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072530395","display_name":"Laura Tarrago\u2010Litvak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Tarrago-Litvak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077776399","display_name":"Ho Chong Hong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ho Chong Hong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1924,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.45082508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"4","first_page":"493","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biotin","display_name":"biotin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.996999979019165},{"id":"https://openalex.org/keywords/glucokinase","display_name":"glucokinase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.675000011920929},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8199999928474426},{"id":"https://openalex.org/keywords/de-novo-protein-synthesis","display_name":"de novo protein synthesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glycolytic-enzymes","display_name":"glycolytic enzymes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/phosphofructokinase","display_name":"phosphofructokinase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pyruvate-kinase","display_name":"pyruvate kinase","score":1.0},{"id":"https://openalex.org/keywords/glucose-6-phosphate-isomerase","display_name":"phosphoglucose isomerase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C88189869","wikidata":"https://www.wikidata.org/wiki/Q418097","display_name":"Glucose-6-phosphate isomerase","level":3,"score":0.7795605659484863},{"id":"https://openalex.org/C98335778","wikidata":"https://www.wikidata.org/wiki/Q425185","display_name":"Glucokinase","level":3,"score":0.7612985372543335},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.7257121801376343},{"id":"https://openalex.org/C58431802","wikidata":"https://www.wikidata.org/wiki/Q420663","display_name":"Phosphofructokinase 2","level":3,"score":0.6619079113006592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6542469263076782},{"id":"https://openalex.org/C122245378","wikidata":"https://www.wikidata.org/wiki/Q14771739","display_name":"Phosphofructokinase","level":4,"score":0.6328890323638916},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.5614272952079773},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5588617324829102},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5078547596931458},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49650222063064575},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4291120767593384},{"id":"https://openalex.org/C2779826832","wikidata":"https://www.wikidata.org/wiki/Q982914","display_name":"Hexokinase","level":4,"score":0.42194512486457825},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.41211652755737305},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4117487370967865}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005956","descriptor_name":"Glucose-6-Phosphate Isomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010732","descriptor_name":"Phosphofructokinase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/o70-079","doi":"https://doi.org/10.1139/o70-079","is_oa":false,"landing_page_url":"https://doi.org/10.1139/o70-079","pdf_url":null,"source":{"id":"https://openalex.org/S4210188051","display_name":"Canadian Journal of Biochemistry","issn_l":"0008-4018","issn":["0008-4018"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:4246111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4246111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2138180048"],"related_works":["https://openalex.org/W1979733421","https://openalex.org/W2117267087","https://openalex.org/W2417218058","https://openalex.org/W2327545107","https://openalex.org/W1984304216","https://openalex.org/W4249658519","https://openalex.org/W4238375209","https://openalex.org/W2021738195","https://openalex.org/W2079348671","https://openalex.org/W1564656332"],"abstract_inverted_index":{"Biotin":[0,26],"enhances":[1],"liver":[2],"glucokinase":[3],"in":[4],"the":[5,30],"diabetic":[6],"rat.":[7],"Experiments":[8],"using":[9],"inhibitors":[10],"of":[11,32],"protein":[12,24],"and":[13,38],"RNA":[14],"synthesis":[15],"suggest":[16],"that":[17],"this":[18],"is":[19],"mediated":[20],"through":[21],"de":[22],"novo":[23],"synthesis.":[25],"treatment":[27],"also":[28],"increases":[29],"activities":[31],"other":[33],"key":[34],"glycolytic":[35],"kinases,":[36],"phosphofructokinase":[37],"pyruvate":[39],"kinase,":[40],"but":[41],"has":[42],"no":[43],"effect":[44],"on":[45],"a":[46],"bifunctional":[47],"enzyme":[48],"like":[49],"phosphohexose":[50],"isomerase.":[51]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}