{"id":"https://openalex.org/W2053534534","doi":"https://doi.org/10.1371/journal.ppat.1000645","title":"High Content Screening Identifies Decaprenyl-Phosphoribose 2\u2032 Epimerase as a Target for Intracellular Antimycobacterial Inhibitors","display_name":"High Content Screening Identifies Decaprenyl-Phosphoribose 2\u2032 Epimerase as a Target for Intracellular Antimycobacterial Inhibitors","publication_year":2009,"publication_date":"2009-10-29","ids":{"openalex":"https://openalex.org/W2053534534","doi":"https://doi.org/10.1371/journal.ppat.1000645","mag":"2053534534","pmid":"https://pubmed.ncbi.nlm.nih.gov/19876393","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2763345"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1000645","doi":"https://doi.org/10.1371/journal.ppat.1000645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000645","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000645&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000645&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108628773","display_name":"Thierry Christophe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Thierry Christophe","raw_affiliation_strings":["Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053151249","display_name":"Mary Jackson","orcid":"https://orcid.org/0000-0002-9212-0258","observed_orcids":["https://orcid.org/0000-0002-9212-0258"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Jackson","raw_affiliation_strings":["Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034111423","display_name":"Hee Kyoung Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Kyoung Jeon","raw_affiliation_strings":["Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009080598","display_name":"Denis Fenistein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Denis Fenistein","raw_affiliation_strings":["Image Mining, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Image Mining, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008895283","display_name":"Monica Contreras-Dom\u00ednguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR","KR"],"is_corresponding":false,"raw_author_name":"Monica Contreras-Dominguez","raw_affiliation_strings":["Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101818961","display_name":"Jaeseung\u00a0C. Kim","orcid":"https://orcid.org/0009-0009-0387-8525","observed_orcids":["https://orcid.org/0009-0009-0387-8525"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaeseung Kim","raw_affiliation_strings":["Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064234141","display_name":"Auguste Genovesio","orcid":"https://orcid.org/0000-0003-1877-5595","observed_orcids":["https://orcid.org/0000-0003-1877-5595"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Auguste Genovesio","raw_affiliation_strings":["Image Mining, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Image Mining, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013759989","display_name":"Jean\u2010Philippe Carralot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR","KR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Carralot","raw_affiliation_strings":["Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074708936","display_name":"Fanny Ewann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR","KR"],"is_corresponding":false,"raw_author_name":"Fanny Ewann","raw_affiliation_strings":["Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648150","display_name":"Eun Hye Kim","orcid":"https://orcid.org/0000-0002-4224-6207","observed_orcids":["https://orcid.org/0000-0002-4224-6207","https://orcid.org/0009-0007-7915-3972","https://orcid.org/0000-0001-6691-6837"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR","KR"],"is_corresponding":false,"raw_author_name":"Eun Hye Kim","raw_affiliation_strings":["Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031385468","display_name":"Sae Yeon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sae Yeon Lee","raw_affiliation_strings":["Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736273","display_name":"Sun\u2010Hee Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunhee Kang","raw_affiliation_strings":["Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102838822","display_name":"Min Jung Seo","orcid":"https://orcid.org/0000-0003-2212-7216","observed_orcids":["https://orcid.org/0000-0003-2212-7216"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Jung Seo","raw_affiliation_strings":["Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eun Jung Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Jung Park","raw_affiliation_strings":["Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060261019","display_name":"Henrieta \u0160kovierov\u00e1","orcid":"https://orcid.org/0000-0002-6854-2338","observed_orcids":["https://orcid.org/0000-0002-6854-2338"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henrieta \u0160kovierov\u00e1","raw_affiliation_strings":["Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032324962","display_name":"Ha T. T. Pham","orcid":"https://orcid.org/0000-0001-8484-470X","observed_orcids":["https://orcid.org/0000-0001-8484-470X"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ha Pham","raw_affiliation_strings":["Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087666815","display_name":"Giovanna Riccardi","orcid":"https://orcid.org/0000-0003-3295-0070","observed_orcids":["https://orcid.org/0000-0003-3295-0070"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanna Riccardi","raw_affiliation_strings":["Dipartimento di Genetica e Microbiologia, Universit\u00e0 degli Studi di Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Genetica e Microbiologia, Universit\u00e0 degli Studi di Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112144124","display_name":"Ji Youn Nam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Youn Nam","raw_affiliation_strings":["Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046905007","display_name":"Laurent Marsollier","orcid":"https://orcid.org/0000-0001-5497-5995","observed_orcids":["https://orcid.org/0000-0001-5497-5995"]},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Marsollier","raw_affiliation_strings":["Groupe d'Etude des Interactions H\u00f4te Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","Groupe d'\u00c9tude des Interactions H\u00f4te-Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe d'Etude des Interactions H\u00f4te Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I49451733"]},{"raw_affiliation_string":"Groupe d'\u00c9tude des Interactions H\u00f4te-Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I49451733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031203797","display_name":"Marie Kempf","orcid":"https://orcid.org/0000-0002-2943-7500","observed_orcids":["https://orcid.org/0000-0002-2943-7500"]},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie Kempf","raw_affiliation_strings":["Groupe d'Etude des Interactions H\u00f4te Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","Groupe d'\u00c9tude des Interactions H\u00f4te-Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe d'Etude des Interactions H\u00f4te Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I49451733"]},{"raw_affiliation_string":"Groupe d'\u00c9tude des Interactions H\u00f4te-Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I49451733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028562294","display_name":"Marie\u2010Laure Joly\u2010Guillou","orcid":"https://orcid.org/0000-0003-2593-6684","observed_orcids":["https://orcid.org/0000-0003-2593-6684"]},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Laure Joly-Guillou","raw_affiliation_strings":["Groupe d'Etude des Interactions H\u00f4te Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","Groupe d'\u00c9tude des Interactions H\u00f4te-Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe d'Etude des Interactions H\u00f4te Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I49451733"]},{"raw_affiliation_string":"Groupe d'\u00c9tude des Interactions H\u00f4te-Pathog\u00e8ne, Universit\u00e9 d'Angers, Angers, France","institution_ids":["https://openalex.org/I49451733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102188802","display_name":"Taegwon Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094349","display_name":"International Tuberculosis Research Center","ror":"https://ror.org/00rpc7954","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210094349"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taegwon Oh","raw_affiliation_strings":["International Tuberculosis Research Center, Masan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Tuberculosis Research Center, Masan, Korea","institution_ids":["https://openalex.org/I4210094349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108462990","display_name":"Won Kyung Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094349","display_name":"International Tuberculosis Research Center","ror":"https://ror.org/00rpc7954","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210094349"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Kyung Shin","raw_affiliation_strings":["International Tuberculosis Research Center, Masan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Tuberculosis Research Center, Masan, Korea","institution_ids":["https://openalex.org/I4210094349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150567","display_name":"Zaesung No","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Zaesung No","raw_affiliation_strings":["Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034632534","display_name":"Ulf Nehrbass","orcid":"https://orcid.org/0000-0002-7028-8076","observed_orcids":["https://orcid.org/0000-0002-7028-8076"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ulf Nehrbass","raw_affiliation_strings":["Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039128760","display_name":"Roland Brosch","orcid":"https://orcid.org/0000-0003-2587-3863","observed_orcids":["https://orcid.org/0000-0003-2587-3863"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roland Brosch","raw_affiliation_strings":["Institut Pasteur, Integrated Mycobacterial Pathogenomics, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Integrated Mycobacterial Pathogenomics, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062153423","display_name":"Stewart Thomas Cole","orcid":"https://orcid.org/0000-0003-1400-5585","observed_orcids":["https://orcid.org/0000-0003-1400-5585"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stewart T. Cole","raw_affiliation_strings":["Global Health Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Health Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078142118","display_name":"Priscille M Brodin","orcid":"https://orcid.org/0000-0003-0991-7344","observed_orcids":["https://orcid.org/0000-0003-0991-7344"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR","KR"],"is_corresponding":true,"raw_author_name":"Priscille Brodin","raw_affiliation_strings":["Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","Institut Pasteur, Integrated Mycobacterial Pathogenomics, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I136761661","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Pasteur, Integrated Mycobacterial Pathogenomics, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5078142118"],"corresponding_institution_ids":["https://openalex.org/I136761661","https://openalex.org/I154526488","https://openalex.org/I157536573"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":12.1928,"has_fulltext":true,"cited_by_count":334,"citation_normalized_percentile":{"value":0.99087512,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":"10","first_page":"e1000645","last_page":"e1000645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dpre1","display_name":"DprE1","score":0.7409999966621399},{"id":"https://openalex.org/keywords/extensively-drug-resistant-tuberculosis","display_name":"extensively drug-resistant tuberculosis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/macrophage-infection","display_name":"macrophage infection","score":0.6190000176429749},{"id":"https://openalex.org/keywords/lipoarabinomannan","display_name":"lipoarabinomannan","score":0.9160000085830688},{"id":"https://openalex.org/keywords/arabinogalactan","display_name":"arabinogalactan","score":0.9940000176429749},{"id":"https://openalex.org/keywords/confocal-fluorescence-microscopy","display_name":"confocal fluorescence microscopy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/drug-target-validation","display_name":"drug target validation","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2779685592","wikidata":"https://www.wikidata.org/wiki/Q2853298","display_name":"Antimycobacterial","level":4,"score":0.9700791835784912},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6614314317703247},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.5311751961708069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4156266748905182},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38555586338043213},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36331307888031006},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.2690141797065735},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23054277896881104},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.1655227541923523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16460669040679932},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.057911187410354614},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000904","descriptor_name":"Antibiotics, Antitubercular","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019998","descriptor_name":"Racemases and Epimerases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.ppat.1000645","doi":"https://doi.org/10.1371/journal.ppat.1000645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000645","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000645&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2763345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2763345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:19876393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19876393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.2521","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.2521","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/fb/45/ppat.1000645.PMC2763345.pdf","raw_type":"text"},{"id":"pmh:oai:scholarcommons.sc.edu:sowk_facpub-1048","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/sowk_facpub/48","pdf_url":null,"source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty and Staff Publications","raw_type":"text"},{"id":"pmh:oai:HAL:hal-02902018v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02902018","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 2009, 5 (10), pp.e1000645. ⟨10.1371/journal.ppat.1000645⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:99417d33f11047f2814f85afb272f7e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/99417d33f11047f2814f85afb272f7e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 5, Iss 10, p e1000645 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/145816","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/High_Content_Screening_Identifies_Decaprenyl_Phosphoribose_2_Epimerase_as_a_Target_for_Intracellular_Antimycobacterial_Inhibitors/145816","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:infoscience.epfl.ch:151182","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/151182","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:151182","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/151182","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1000645","doi":"https://doi.org/10.1371/journal.ppat.1000645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000645","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000645&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1505653794","display_name":null,"funder_award_id":"LHSP-CT-2005-018923","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5152944320","display_name":"Biogenesis of Lipoarabinomannan in Mycobacteria","funder_award_id":"R01AI064798","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053534534.pdf","grobid_xml":"https://content.openalex.org/works/W2053534534.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1521708238","https://openalex.org/W1538374398","https://openalex.org/W1548106543","https://openalex.org/W1798947166","https://openalex.org/W1964141703","https://openalex.org/W1976256007","https://openalex.org/W1988600626","https://openalex.org/W2007097682","https://openalex.org/W2028431045","https://openalex.org/W2059750112","https://openalex.org/W2064097501","https://openalex.org/W2064953244","https://openalex.org/W2064964564","https://openalex.org/W2067776060","https://openalex.org/W2070361087","https://openalex.org/W2073502830","https://openalex.org/W2081206347","https://openalex.org/W2090197974","https://openalex.org/W2096520521","https://openalex.org/W2098793988","https://openalex.org/W2100383399","https://openalex.org/W2115477132","https://openalex.org/W2116128143","https://openalex.org/W2121449107","https://openalex.org/W2128482141","https://openalex.org/W2129816077","https://openalex.org/W2133262376","https://openalex.org/W2135721651","https://openalex.org/W2135732933","https://openalex.org/W2136913089","https://openalex.org/W2138854013","https://openalex.org/W2145085703","https://openalex.org/W2158023121","https://openalex.org/W2158658436","https://openalex.org/W2165418498","https://openalex.org/W2166305071"],"related_works":["https://openalex.org/W7099567097","https://openalex.org/W2117987331","https://openalex.org/W2904784469","https://openalex.org/W1986288809","https://openalex.org/W2338457561","https://openalex.org/W7134175976","https://openalex.org/W4386624614","https://openalex.org/W2981036540","https://openalex.org/W3199627185","https://openalex.org/W4323653295"],"abstract_inverted_index":{"A":[0],"critical":[1],"feature":[2],"of":[3,9,57,65,80,87,95,103,141,149,158,169,200],"Mycobacterium":[4],"tuberculosis,":[5,128],"the":[6,33,63,85,101,119,147,156,163,185,197],"causative":[7],"agent":[8],"human":[10],"tuberculosis":[11,43,89,143],"(TB),":[12],"is":[13,37],"its":[14],"ability":[15],"to":[16,100,155,176],"survive":[17],"and":[18,55,112,152],"multiply":[19],"within":[20,90],"macrophages,":[21],"making":[22],"these":[23],"host":[24,114],"cells":[25],"an":[26],"ideal":[27],"niche":[28],"for":[29,41,76,195],"persisting":[30],"microbes.":[31],"Killing":[32],"intracellular":[34,109],"tubercle":[35],"bacilli":[36],"a":[38,66,93],"key":[39],"requirement":[40],"efficient":[42],"treatment,":[44],"yet":[45],"identifying":[46],"potent":[47,108],"inhibitors":[48],"has":[49],"been":[50],"hampered":[51],"by":[52,162],"labor-intensive":[53],"techniques":[54],"lack":[56],"validated":[58],"targets.":[59],"Here,":[60],"we":[61,137],"present":[62],"development":[64],"phenotypic":[67],"cell-based":[68],"assay":[69],"that":[70,82,139],"uses":[71],"automated":[72],"confocal":[73],"fluorescence":[74],"microscopy":[75],"high":[77,124,186],"throughput":[78],"screening":[79,188],"chemicals":[81],"interfere":[83],"with":[84,107,144],"replication":[86],"M.":[88,127,142],"macrophages.":[91],"Screening":[92],"library":[94],"57,000":[96],"small":[97],"molecules":[98],"led":[99],"identification":[102],"135":[104],"active":[105],"compounds":[106],"anti-mycobacterial":[110],"efficacy":[111],"no":[113],"cell":[115],"toxicity.":[116],"Among":[117],"these,":[118],"dinitrobenzamide":[120],"derivatives":[121],"(DNB)":[122],"showed":[123],"activity":[125],"against":[126,180],"including":[129],"extensively":[130],"drug":[131],"resistant":[132],"(XDR)":[133],"strains.":[134],"More":[135],"importantly,":[136],"demonstrate":[138],"incubation":[140],"DNB":[145],"inhibited":[146],"formation":[148],"both":[150],"lipoarabinomannan":[151],"arabinogalactan,":[153],"attributable":[154],"inhibition":[157],"decaprenyl-phospho-arabinose":[159],"synthesis":[160],"catalyzed":[161],"decaprenyl-phosphoribose":[164],"2'":[165],"epimerase":[166],"DprE1/DprE2.":[167],"Inhibition":[168],"this":[170],"new":[171,177,193],"target":[172],"will":[173],"likely":[174],"contribute":[175],"therapeutic":[178],"solutions":[179],"emerging":[181],"XDR-TB.":[182],"Beyond":[183],"validating":[184],"throughput/content":[187],"approach,":[189],"our":[190],"results":[191],"open":[192],"avenues":[194],"finding":[196],"next":[198],"generation":[199],"antimicrobials.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}