{"id":"https://openalex.org/W2053500348","doi":"https://doi.org/10.1021/jm5003606","title":"Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent","display_name":"Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent","publication_year":2014,"publication_date":"2014-05-28","ids":{"openalex":"https://openalex.org/W2053500348","doi":"https://doi.org/10.1021/jm5003606","mag":"2053500348","pmid":"https://pubmed.ncbi.nlm.nih.gov/24870926"},"language":"en","primary_location":{"id":"doi:10.1021/jm5003606","doi":"https://doi.org/10.1021/jm5003606","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm5003606","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111736273","display_name":"Sun\u2010Hee Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunhee Kang","raw_affiliation_strings":["Medicinal and Bioorganic Chemistry Group, \u2021Antibacterial Drug Discovery Group, and \u00a7Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea , 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal and Bioorganic Chemistry Group, \u2021Antibacterial Drug Discovery Group, and \u00a7Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea , 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010830733","display_name":"Ryang Yeo Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ryang Yeo Kim","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102838822","display_name":"Min Jung Seo","orcid":"https://orcid.org/0000-0003-2212-7216","observed_orcids":["https://orcid.org/0000-0003-2212-7216"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Jung Seo","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040676479","display_name":"Saeyeon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Saeyeon Lee","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780391","display_name":"Young Mi Kim","orcid":"https://orcid.org/0000-0002-8815-4957","observed_orcids":["https://orcid.org/0000-0002-8815-4957"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Mi Kim","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035646425","display_name":"Mooyoung Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mooyoung Seo","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062044719","display_name":"Jeong Jea Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong Jea Seo","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088584932","display_name":"Yoonae Ko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoonae Ko","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085207816","display_name":"Inhee Choi","orcid":"https://orcid.org/0000-0001-7884-1764","observed_orcids":["https://orcid.org/0000-0001-7884-1764"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Inhee Choi","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003362173","display_name":"Jichan Jang","orcid":"https://orcid.org/0000-0002-4598-5371","observed_orcids":["https://orcid.org/0000-0002-4598-5371"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jichan Jang","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676232","display_name":"Jiyoun Nam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiyoun Nam","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Seijin Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seijin Park","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010271373","display_name":"Hwankyu Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hwankyu Kang","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002712420","display_name":"Hyung Jun Kim","orcid":"https://orcid.org/0000-0001-8247-4004","observed_orcids":["https://orcid.org/0000-0001-8247-4004","https://orcid.org/0009-0003-5078-4405"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung Jun Kim","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jungjun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jungjun Kim","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro,\r712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","Qurient Incorporated, 16 Daewnagpangyo-ro,#R#712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro,\r712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro,#R#712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102445112","display_name":"Sujin Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sujin Ahn","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089521333","display_name":"K\u00e9vin Pethe","orcid":"https://orcid.org/0000-0003-0916-8873","observed_orcids":["https://orcid.org/0000-0003-0916-8873"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]},{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kevin Pethe","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kiyean Nam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kiyean Nam","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro,\r712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","Qurient Incorporated, 16 Daewnagpangyo-ro,#R#712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro,\r712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]},{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro,#R#712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150567","display_name":"Zaesung No","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Zaesung No","raw_affiliation_strings":["\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Medicinal and Bioorganic Chemistry Group, \u2021 Antibacterial Drug Discovery Group, and \u00a7 Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea, 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101818961","display_name":"Jaeseung\u00a0C. Kim","orcid":"https://orcid.org/0009-0009-0387-8525","observed_orcids":["https://orcid.org/0009-0009-0387-8525"]},"institutions":[{"id":"https://openalex.org/I4210158309","display_name":"Qurient (South Korea)","ror":"https://ror.org/058kbr222","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210158309"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jaeseung Kim","raw_affiliation_strings":["Qurient Incorporated, 16 Daewnagpangyo-ro,\r712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qurient Incorporated, 16 Daewnagpangyo-ro,\r712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I4210158309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101818961","https://openalex.org/A5109150567"],"corresponding_institution_ids":["https://openalex.org/I136761661","https://openalex.org/I4210158309"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":11.7002,"has_fulltext":false,"cited_by_count":179,"citation_normalized_percentile":{"value":0.99076403,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"57","issue":"12","first_page":"5293","last_page":"5305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.20630000531673431,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.12929999828338623,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/q203","display_name":"Q203","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anti-tuberculosis-agents","display_name":"anti-tuberculosis agents","score":0.8429999947547913},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/extensively-drug-resistant-tuberculosis","display_name":"extensively drug-resistant tuberculosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis-h37rv","display_name":"Mycobacterium tuberculosis H37Rv","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.7820000052452087},{"id":"https://openalex.org/keywords/amide-linker","display_name":"amide linker","score":0.8690000176429749},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mouse-lung-infection-model","display_name":"mouse lung infection model","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8015762567520142},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6938614249229431},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6334078311920166},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5995007157325745},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5752946734428406},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5581456422805786},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.5430073738098145},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.4939618706703186},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4937363564968109},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.48516207933425903},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.47449326515197754},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3794527053833008},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3014969825744629},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2984788119792938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13557127118110657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11762544512748718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm5003606","doi":"https://doi.org/10.1021/jm5003606","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm5003606","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:24870926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24870926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1538374398","https://openalex.org/W1964484331","https://openalex.org/W1974074976","https://openalex.org/W1976256007","https://openalex.org/W1980682275","https://openalex.org/W1984844353","https://openalex.org/W1996794817","https://openalex.org/W2047329567","https://openalex.org/W2053534534","https://openalex.org/W2092679747","https://openalex.org/W2095318368","https://openalex.org/W2095717898","https://openalex.org/W2109423297","https://openalex.org/W2158658436","https://openalex.org/W2164918529","https://openalex.org/W2176385519"],"related_works":["https://openalex.org/W7155636570","https://openalex.org/W2906819235","https://openalex.org/W2092679747","https://openalex.org/W2315310851","https://openalex.org/W3032967055","https://openalex.org/W4230172944","https://openalex.org/W2987721602","https://openalex.org/W1980651896","https://openalex.org/W2531631745","https://openalex.org/W4205266047"],"abstract_inverted_index":{"A":[0],"critical":[1,86],"unmet":[2],"clinical":[3],"need":[4],"to":[5,47],"combat":[6],"the":[7,12,20,36,48,58,77,81,119],"global":[8],"tuberculosis":[9,28,71],"epidemic":[10],"is":[11,64],"development":[13],"of":[14,18,22,38,52,76,118],"potent":[15],"agents":[16],"capable":[17],"reducing":[19],"time":[21],"multi-drug-resistant":[23],"(MDR)":[24],"and":[25,50,74,92,96,103,112,133],"extensively-drug-resistant":[26],"(XDR)":[27],"therapy.":[29],"In":[30],"this":[31],"paper,":[32],"we":[33],"report":[34],"on":[35],"optimization":[37],"imidazo[1,2-a]pyridine":[39],"amide":[40,59],"(IPA)":[41],"lead":[42],"compound":[43],"1,":[44],"which":[45],"led":[46],"design":[49],"synthesis":[51],"Q203":[53],"(50).":[54],"We":[55],"found":[56],"that":[57],"linker":[60],"with":[61,115],"IPA":[62,82],"core":[63],"very":[65],"important":[66],"for":[67],"activity":[68],"against":[69],"Mycobacterium":[70],"H37Rv.":[72],"Linearity":[73],"lipophilicity":[75],"amine":[78],"part":[79],"in":[80,88,90,93,143],"series":[83],"play":[84],"a":[85],"role":[87],"improving":[89],"vitro":[91],"vivo":[94],"efficacy":[95],"pharmacokinetic":[97],"profile.":[98],"The":[99],"optimized":[100],"IPAs":[101],"49":[102],"50":[104],"showed":[105],"not":[106],"only":[107],"excellent":[108],"oral":[109],"bioavailability":[110],"(80.2%":[111],"90.7%,":[113],"respectively)":[114,142],"high":[116],"exposure":[117],"area":[120],"under":[121],"curve":[122],"(AUC)":[123],"but":[124],"also":[125],"displayed":[126],"significant":[127],"colony-forming":[128],"unit":[129],"(CFU)":[130],"reduction":[131,136],"(1.52":[132],"3.13":[134],"log10":[135],"at":[137],"10":[138],"mg/kg":[139],"dosing":[140],"level,":[141],"mouse":[144],"lung.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
