{"id":"https://openalex.org/W2053497466","doi":"https://doi.org/10.1016/s0303-7207(98)00035-5","title":"Asphyxial brain injury\u2014the role of the IGF system","display_name":"Asphyxial brain injury\u2014the role of the IGF system","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2053497466","doi":"https://doi.org/10.1016/s0303-7207(98)00035-5","mag":"2053497466","pmid":"https://pubmed.ncbi.nlm.nih.gov/9722175"},"language":"en","primary_location":{"id":"doi:10.1016/s0303-7207(98)00035-5","doi":"https://doi.org/10.1016/s0303-7207(98)00035-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0303-7207(98)00035-5","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058979039","display_name":"Peter David Gluckman","orcid":"https://orcid.org/0000-0002-5711-1655","observed_orcids":["https://orcid.org/0000-0002-5711-1655"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"P.D. Gluckman","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand. pd.gluckman@auckland.ac.nz","Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand. pd.gluckman@auckland.ac.nz","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057130892","display_name":"Jian Guan","orcid":"https://orcid.org/0000-0002-2847-1627","observed_orcids":["https://orcid.org/0000-0002-2847-1627"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"J. Guan","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055947201","display_name":"Chris Williams","orcid":"https://orcid.org/0000-0003-1757-6156","observed_orcids":["https://orcid.org/0000-0003-1757-6156"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"C. Williams","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058621977","display_name":"Arjan Scheepens","orcid":"https://orcid.org/0000-0003-4624-4046","observed_orcids":["https://orcid.org/0000-0003-4624-4046"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"A. Scheepens","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014180686","display_name":"Rong Zhang","orcid":"https://orcid.org/0000-0001-5066-3484","observed_orcids":["https://orcid.org/0000-0001-5066-3484"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"R. Zhang","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039019537","display_name":"Laura Bennet","orcid":"https://orcid.org/0000-0002-4336-7596","observed_orcids":["https://orcid.org/0000-0002-4336-7596"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"L. Bennet","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047041488","display_name":"Alistair Jan Gunn","orcid":"https://orcid.org/0000-0003-0656-7035","observed_orcids":["https://orcid.org/0000-0003-0656-7035"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"A. Gunn","raw_affiliation_strings":["Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058979039"],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":0.7603,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.61298077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"140","issue":"1-2","first_page":"95","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-system","display_name":"IGF system","score":0.6679999828338623},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7889999747276306},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.8059999942779541},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-protein-3","display_name":"insulin-like growth factor binding protein-3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/delayed-neuronal-death","display_name":"delayed neuronal death","score":0.8669999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8859999775886536},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/perinatal-asphyxia","display_name":"perinatal asphyxia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9300000071525574},{"id":"https://openalex.org/keywords/acute-brain-injury","display_name":"acute brain injury","score":0.8050000071525574},{"id":"https://openalex.org/keywords/igf-1-therapy","display_name":"IGF-1 therapy","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8923674821853638},{"id":"https://openalex.org/C2779914510","wikidata":"https://www.wikidata.org/wiki/Q193840","display_name":"Asphyxia","level":2,"score":0.6015692949295044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4872225821018219},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48316043615341187},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.468738853931427},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4643189609050751},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.455354243516922},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4322265088558197},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.415727436542511},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40065065026283264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32684358954429626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3240507245063782},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31032443046569824},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.24614965915679932},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05918937921524048}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001237","descriptor_name":"Asphyxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002534","descriptor_name":"Hypoxia, Brain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002534","descriptor_name":"Hypoxia, Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0303-7207(98)00035-5","doi":"https://doi.org/10.1016/s0303-7207(98)00035-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0303-7207(98)00035-5","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},{"id":"pmid:9722175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9722175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334749","display_name":"Health Research Council of New Zealand","ror":"https://ror.org/00zbf3d93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1954313480","https://openalex.org/W1964471002","https://openalex.org/W1969304166","https://openalex.org/W1980920786","https://openalex.org/W1986472833","https://openalex.org/W1990862055","https://openalex.org/W1993356072","https://openalex.org/W1994048302","https://openalex.org/W2012975747","https://openalex.org/W2013774985","https://openalex.org/W2018717300","https://openalex.org/W2019699562","https://openalex.org/W2023093915","https://openalex.org/W2029629215","https://openalex.org/W2048847921","https://openalex.org/W2050286612","https://openalex.org/W2052037092","https://openalex.org/W2053615617","https://openalex.org/W2053765138","https://openalex.org/W2060236262","https://openalex.org/W2069398669","https://openalex.org/W2080501689","https://openalex.org/W2086288645","https://openalex.org/W2086492121","https://openalex.org/W2089146248","https://openalex.org/W2091555142","https://openalex.org/W2095111472","https://openalex.org/W2102437478","https://openalex.org/W2102527735"],"related_works":["https://openalex.org/W2056875210","https://openalex.org/W79328412","https://openalex.org/W1174340403","https://openalex.org/W2057192508","https://openalex.org/W1489143848","https://openalex.org/W1990862055","https://openalex.org/W2041171099","https://openalex.org/W2075877539","https://openalex.org/W2097891309","https://openalex.org/W93566316"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}