{"id":"https://openalex.org/W2053485168","doi":"https://doi.org/10.1039/b814075h","title":"The biosynthetic genecluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892","display_name":"The biosynthetic genecluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892","publication_year":2008,"publication_date":"2008-11-12","ids":{"openalex":"https://openalex.org/W2053485168","doi":"https://doi.org/10.1039/b814075h","mag":"2053485168","pmid":"https://pubmed.ncbi.nlm.nih.gov/19081934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3086045"},"language":"en","primary_location":{"id":"doi:10.1039/b814075h","doi":"https://doi.org/10.1039/b814075h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b814075h","pdf_url":null,"source":{"id":"https://openalex.org/S169293703","display_name":"Molecular BioSystems","issn_l":"1742-2051","issn":["1742-2051","1742-206X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular BioSystems","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3086045","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034021974","display_name":"Ute Galm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ute Galm","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043947954","display_name":"Evelyn Wendt-Pienkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelyn Wendt-Pienkowski","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liyan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liyan Wang","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051841368","display_name":"Nicholas P. George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas P George","raw_affiliation_strings":["Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. b , Madison, Wisconsin 53705, USA","Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. b , Madison, Wisconsin 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072379641","display_name":"Tae\u2010Jin Oh","orcid":"https://orcid.org/0000-0002-8407-5039","observed_orcids":["https://orcid.org/0000-0002-8407-5039"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae-Jin Oh","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fan Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Yi","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081023811","display_name":"Meifeng Tao","orcid":"https://orcid.org/0000-0001-9829-7591","observed_orcids":["https://orcid.org/0000-0001-9829-7591"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meifeng Tao","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003308088","display_name":"Jane M. Coughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane M Coughlin","raw_affiliation_strings":["Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. c , Madison, Wisconsin 53705, USA","Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. c , Madison, Wisconsin 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087514362","display_name":"Ben Shen","orcid":"https://orcid.org/0000-0002-9750-5982","observed_orcids":["https://orcid.org/0000-0002-9750-5982"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ben Shen","raw_affiliation_strings":["Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. c , Madison, Wisconsin 53705, USA","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. b , Madison, Wisconsin 53705, USA","University of Wisconsin National Cooperative Drug Discovery Group, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. d , Madison, Wisconsin 53705, USA","Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","University of Wisconsin National Cooperative Drug Discovery Group, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. c , Madison, Wisconsin 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. a , Madison, Wisconsin 53705, USA \u00a0 bshen@pharmacy.wisc.edu \u00a0 +1 608 262-5345 \u00a0 +1 608 263-2673","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. b , Madison, Wisconsin 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin National Cooperative Drug Discovery Group, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave. d , Madison, Wisconsin 53705, USA","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemistry, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Microbiology Doctoral Training Program, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin National Cooperative Drug Discovery Group, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Ave., Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087514362"],"corresponding_institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":1.5712,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.77800938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"77","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosynthetic-gene-clusters","display_name":"biosynthetic gene clusters","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antitumor-antibiotics","display_name":"antitumor antibiotics","score":0.8709999918937683},{"id":"https://openalex.org/keywords/nonribosomal-peptide-synthetase","display_name":"nonribosomal peptide synthetase","score":0.925000011920929},{"id":"https://openalex.org/keywords/polyketide-synthase","display_name":"polyketide synthase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/intergeneric-conjugation","display_name":"intergeneric conjugation","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.8765368461608887},{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.8709540367126465},{"id":"https://openalex.org/C2777379556","wikidata":"https://www.wikidata.org/wiki/Q1443801","display_name":"Nonribosomal peptide","level":4,"score":0.738923966884613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6929287910461426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6576277613639832},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5502418279647827},{"id":"https://openalex.org/C35101798","wikidata":"https://www.wikidata.org/wiki/Q414491","display_name":"Cosmid","level":3,"score":0.5196929574012756},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.5057713985443115},{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.4394623637199402},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.42268407344818115},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.37874358892440796},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.26370179653167725},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08535441756248474}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/b814075h","doi":"https://doi.org/10.1039/b814075h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b814075h","pdf_url":null,"source":{"id":"https://openalex.org/S169293703","display_name":"Molecular BioSystems","issn_l":"1742-2051","issn":["1742-2051","1742-206X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular BioSystems","raw_type":"journal-article"},{"id":"pmid:19081934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19081934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular bioSystems","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3086045","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3086045","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Biosyst","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3086045","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3086045","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Biosyst","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6558723668","display_name":"Biosynthesis of hybrid peptide-polyketide antibiotics","funder_award_id":"R01CA094426","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G826341569","display_name":"Chemistry-Biology Interface Training Program","funder_award_id":"T32GM008505","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1521817136","https://openalex.org/W1533458170","https://openalex.org/W1587696955","https://openalex.org/W1827848435","https://openalex.org/W1964516896","https://openalex.org/W1968654436","https://openalex.org/W1977277805","https://openalex.org/W1978438460","https://openalex.org/W1994380180","https://openalex.org/W1995995599","https://openalex.org/W1996206456","https://openalex.org/W2001351478","https://openalex.org/W2006326877","https://openalex.org/W2019854086","https://openalex.org/W2023603054","https://openalex.org/W2023950913","https://openalex.org/W2025234908","https://openalex.org/W2026232802","https://openalex.org/W2033231221","https://openalex.org/W2041254003","https://openalex.org/W2045224145","https://openalex.org/W2045246791","https://openalex.org/W2045659313","https://openalex.org/W2059397761","https://openalex.org/W2059420054","https://openalex.org/W2062185057","https://openalex.org/W2068312503","https://openalex.org/W2070283896","https://openalex.org/W2080895748","https://openalex.org/W2082165572","https://openalex.org/W2085131893","https://openalex.org/W2096970379","https://openalex.org/W2098302192","https://openalex.org/W2099518937","https://openalex.org/W2100747985","https://openalex.org/W2106913347","https://openalex.org/W2110216380","https://openalex.org/W2111404134","https://openalex.org/W2114839447","https://openalex.org/W2123244672","https://openalex.org/W2126708779","https://openalex.org/W2146883739","https://openalex.org/W2149901522","https://openalex.org/W2153530580","https://openalex.org/W2159334876","https://openalex.org/W2409187476","https://openalex.org/W2413315376","https://openalex.org/W2511388779","https://openalex.org/W2591339225","https://openalex.org/W2804007336"],"related_works":["https://openalex.org/W2013573375","https://openalex.org/W2126708779","https://openalex.org/W2023603054","https://openalex.org/W2111404134","https://openalex.org/W2296868086","https://openalex.org/W7096008991","https://openalex.org/W2039930243","https://openalex.org/W2484471024","https://openalex.org/W4241684496","https://openalex.org/W2006604775"],"abstract_inverted_index":{"The":[0,74],"biosynthetic":[1,32,46,147],"gene":[2,33,47,76,109,142],"cluster":[3,77,143],"for":[4,49],"the":[5,30,45,50,57,68],"glycopeptide-derived":[6],"antitumor":[7],"antibiotic":[8],"zorbamycin":[9],"(ZBM)":[10],"was":[11,137],"cloned":[12],"by":[13],"screening":[14],"a":[15,105],"cosmid":[16],"library":[17],"of":[18,79],"Streptomyces":[19],"flavoviridis":[20,134],"ATCC":[21],"21892.":[22],"Sequence":[23],"analysis":[24],"revealed":[25],"40":[26],"ORFs":[27,40,59,66],"belonging":[28],"to":[29,44,65,139],"ZBM":[31,75,141],"cluster.":[34],"However,":[35],"only":[36],"23":[37],"and":[38,53,71,96,125,146],"22":[39],"showed":[41],"striking":[42],"similarities":[43],"clusters":[48],"bleomycins":[51],"(BLMs)":[52],"tallysomycins":[54],"(TLMs),":[55],"respectively;":[56],"remaining":[58],"do":[60],"not":[61],"show":[62],"significant":[63],"homology":[64],"from":[67],"related":[69],"BLM":[70],"TLM":[72],"clusters.":[73],"consists":[78],"16":[80],"nonribosomal":[81],"peptide":[82],"synthetase":[83],"(NRPS)":[84],"genes":[85,121],"encoding":[86,110,122],"eight":[87,97],"complete":[88],"NRPS":[89,94,100],"modules,":[90,95],"three":[91],"incomplete":[92],"didomain":[93],"freestanding":[98],"single":[99],"domains":[101],"or":[102],"associated":[103],"enzymes,":[104],"polyketide":[106],"synthase":[107],"(PKS)":[108],"one":[111],"PKS":[112],"module,":[113],"six":[114],"sugar":[115],"biosynthesis":[116,124],"genes,":[117],"as":[118,120],"well":[119],"other":[123],"resistance":[126],"proteins.":[127],"A":[128],"genetic":[129],"system":[130],"using":[131],"Escherichia":[132],"coli-Streptomyces":[133],"intergeneric":[135],"conjugation":[136],"developed":[138],"enable":[140],"boundary":[144],"determinations":[145],"pathway":[148],"manipulations.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}