{"id":"https://openalex.org/W2053475128","doi":"https://doi.org/10.1373/clinchem.2007.101303","title":"Free Testosterone Measurement by the Analog Displacement Direct Assay: Old Concerns and New Evidence","display_name":"Free Testosterone Measurement by the Analog Displacement Direct Assay: Old Concerns and New Evidence","publication_year":2008,"publication_date":"2008-02-29","ids":{"openalex":"https://openalex.org/W2053475128","doi":"https://doi.org/10.1373/clinchem.2007.101303","mag":"2053475128","pmid":"https://pubmed.ncbi.nlm.nih.gov/18310144"},"language":"en","primary_location":{"id":"doi:10.1373/clinchem.2007.101303","doi":"https://doi.org/10.1373/clinchem.2007.101303","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2007.101303","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090807122","display_name":"Ronald S. Swerdloff","orcid":"https://orcid.org/0000-0001-6084-6604","observed_orcids":["https://orcid.org/0000-0001-6084-6604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald S Swerdloff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100616719","display_name":"Christina Wang","orcid":"https://orcid.org/0000-0002-8231-792X","observed_orcids":["https://orcid.org/0000-0002-8231-792X"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Wang","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance CA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"3","first_page":"458","last_page":"460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-testosterone","display_name":"free testosterone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/assay-validity","display_name":"assay validity","score":0.652999997138977},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/total-testosterone","display_name":"total testosterone","score":0.6869999766349792},{"id":"https://openalex.org/keywords/testosterone-binding","display_name":"testosterone binding","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2910497653","wikidata":"https://www.wikidata.org/wiki/Q1318776","display_name":"Free testosterone","level":5,"score":0.5937912464141846},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5666918754577637},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.48559874296188354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.358633816242218},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34292688965797424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3396355211734772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31990164518356323},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22487059235572815},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1160685122013092},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.08650687336921692},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.07811078429222107},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.06790795922279358}],"mesh":[{"descriptor_ui":"D003956","descriptor_name":"Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1373/clinchem.2007.101303","doi":"https://doi.org/10.1373/clinchem.2007.101303","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2007.101303","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:18310144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18310144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Comment"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1033.7171","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1033.7171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://clinchem.aaccjnls.org/content/clinchem/54/3/458.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1966986320","https://openalex.org/W1981843591","https://openalex.org/W2005966256","https://openalex.org/W2048389747","https://openalex.org/W2094539633","https://openalex.org/W2098247759","https://openalex.org/W2103054709","https://openalex.org/W2112140159","https://openalex.org/W2116313303","https://openalex.org/W2117000551","https://openalex.org/W2119682509","https://openalex.org/W2142839710","https://openalex.org/W2144756371","https://openalex.org/W2157527766","https://openalex.org/W3036378166"],"related_works":["https://openalex.org/W2116313303","https://openalex.org/W2927828943","https://openalex.org/W1910821976","https://openalex.org/W2345400586","https://openalex.org/W7096855292","https://openalex.org/W2103054709","https://openalex.org/W7096322944","https://openalex.org/W2984758666","https://openalex.org/W2094539633","https://openalex.org/W2552792793"],"abstract_inverted_index":{"Fritz":[0],"and":[1,29,70,87,104],"coworkers":[2],"(1)":[3],"have":[4],"provided":[5],"data":[6],"arguing":[7],"against":[8],"the":[9,27,37,65,83],"validity":[10],"of":[11,24,26,31,60,71,85],"a":[12],"popular":[13],"analog-based":[14],"direct":[15],"assay":[16,28,38,61],"for":[17],"free":[18],"testosterone":[19],"(T).":[20],"Their":[21],"rigorous":[22],"dissec-tion":[23],"characteristics":[25],"use":[30],"carefully":[32],"defined":[33],"solutions":[34],"demonstrates":[35],"that":[36],"corre-lates":[39],"generally":[40],"with":[41,54],"total":[42],"T":[43],"but":[44,112],"does":[45],"not":[46,113],"measure":[47],"dia-lyzable":[48],"T;":[49],"this":[50,58],"observation":[51],"is":[52,93],"consistent":[53],"prior":[55],"res-ervations":[56],"about":[57],"class":[59],"by":[62,64],"reported":[63],"Endocrine":[66],"Society":[67],"(2,":[68],"3)":[69],"other":[72],"investigators":[73],"(4\u20136).":[74],"WHY":[75],"WORRY":[76],"ABOUT":[77],"FREE":[78],"T?":[79],"Testosterone":[80],"circulates":[81],"in":[82,89],"blood":[84],"men":[86],"women":[88],"several":[90],"forms.":[91],"It":[92],"bound":[94],"tightly":[95],"to":[96,102,106],"sex-hor-mone":[97],"binding":[98],"globulin":[99],"(SHBG),":[100],"loosely":[101],"albumin,":[103],"unbound":[105],"proteins":[107],"(free)":[108],"(7).":[109],"In":[110],"most,":[111]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
