{"id":"https://openalex.org/W2053469714","doi":"https://doi.org/10.1159/000204831","title":"Changes in CuZn-Superoxide Dismutase Gene during Induced Erythroid and Myeloid Differentiation","display_name":"Changes in CuZn-Superoxide Dismutase Gene during Induced Erythroid and Myeloid Differentiation","publication_year":2009,"publication_date":"2009-02-19","ids":{"openalex":"https://openalex.org/W2053469714","doi":"https://doi.org/10.1159/000204831","mag":"2053469714","pmid":"https://pubmed.ncbi.nlm.nih.gov/1805485"},"language":"en","primary_location":{"id":"doi:10.1159/000204831","doi":"https://doi.org/10.1159/000204831","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000204831","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085602277","display_name":"Takashi Tomoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]},{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Tomoda","raw_affiliation_strings":["Department of Pediatrics, Kochi Medical School, Japan","Department of Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kochi Medical School, Japan","institution_ids":["https://openalex.org/I4210088960","https://openalex.org/I77063589"]},{"raw_affiliation_string":"Department of Pediatrics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112317797","display_name":"Ichiro Nomura","orcid":"https://orcid.org/0000-0001-9204-5465","observed_orcids":["https://orcid.org/0000-0001-9204-5465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ichiro Nomura","raw_affiliation_strings":["Department of Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108469473","display_name":"Takanobu Kurashige","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takanobu Kurashige","raw_affiliation_strings":["Department of Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028576904","display_name":"Ichiro Kubonishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ichiro Kubonishi","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015896709","display_name":"Isao Miyoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isao Miyoshi","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090460998","display_name":"Yoshikazu Sukenaga","orcid":"https://orcid.org/0000-0001-8479-3842","observed_orcids":["https://orcid.org/0000-0001-8479-3842"]},"institutions":[{"id":"https://openalex.org/I4210150228","display_name":"Nippon Kayaku (Japan)","ror":"https://ror.org/05cbf4214","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210150228"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Sukenaga","raw_affiliation_strings":["Research Laboratories, Pharmaceuticals Group, Nippon Kayaku Co., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Pharmaceuticals Group, Nippon Kayaku Co., Tokyo, Japan","institution_ids":["https://openalex.org/I4210150228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100880064","display_name":"Taketoshi Taniguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taketoshi Taniguchi","raw_affiliation_strings":["Medical Research Laboratory, Kochi Medical School, Kochi, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Laboratory, Kochi Medical School, Kochi, and","institution_ids":["https://openalex.org/I4210088960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1099,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.44774393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"86","issue":"4","first_page":"183","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.3384000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.3384000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.26440000534057617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.17710000276565552,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cu-zn-superoxide-dismutase","display_name":"Cu/Zn superoxide dismutase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myeloid-differentiation","display_name":"myeloid differentiation","score":1.0},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5600000023841858},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.7440000176429749},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.9039999842643738},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/leukemia-cell-differentiation","display_name":"leukemia cell differentiation","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.9006725549697876},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.737086832523346},{"id":"https://openalex.org/C2777723881","wikidata":"https://www.wikidata.org/wiki/Q107315604","display_name":"Hemin","level":4,"score":0.6225729584693909},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5759169459342957},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5700221061706543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5182744860649109},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.5147883892059326},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4925699830055237},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.41913846135139465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4018670618534088},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37755098938941956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3762168288230896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21476826071739197},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15048187971115112},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.1109357476234436}],"mesh":[{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000204831","doi":"https://doi.org/10.1159/000204831","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000204831","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:1805485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1805485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130000381","https://openalex.org/W1990128425","https://openalex.org/W292657343","https://openalex.org/W1532388415","https://openalex.org/W175818448","https://openalex.org/W57597108","https://openalex.org/W1965287091","https://openalex.org/W1964185625","https://openalex.org/W2740722830","https://openalex.org/W2089913301"],"abstract_inverted_index":{"We":[0,24],"investigated":[1],"the":[2,35,53,68,85,96,99,103,115,135,144,162,171],"alteration":[3],"of":[4,22,31,37,55,67,84,117,137,143,164],"Cu,Zn-superoxide":[5,79,91,138,153],"dismutase":[6,33,80,92,139,154,166],"during":[7],"erythroid":[8,40,77,172],"and":[9,28,65,88,150],"myeloid":[10,43,133,174],"differentiation":[11,38,175],"in":[12,19,34,52,114],"order":[13],"to":[14,39,95,98],"elucidate":[15],"its":[16],"physiological":[17],"significance":[18],"different":[20],"types":[21],"cells.":[23,44],"measured":[25],"enzyme":[26],"activity":[27,81,97,136],"mRNA":[29,89,151],"levels":[30],"superoxide":[32,165],"process":[36],"cells":[41,49,60,69,111,123],"or":[42,173],"When":[45],"human":[46,107],"leukemia":[47,109],"K562":[48],"are":[50,112],"incubated":[51,113],"presence":[54,116],"80":[56],"microM":[57],"hemin,":[58],"benzidine-positive":[59],"appear":[61],"on":[62,72,127,147],"day":[63,73,128,148],"1":[64],"80%":[66],"become":[70],"positive":[71],"5.":[74,129],"During":[75,130],"hemin-induced":[76],"differentiation,":[78,134],"increases":[82,93],"3.5-fold":[83],"initial":[86,145],"value":[87,146],"for":[90,152],"prior":[94],"same":[100],"extent.":[101],"On":[102],"other":[104],"hand,":[105],"when":[106],"promyelocytic":[108],"HL-60":[110],"1.3%":[118],"dimethyl":[119,131],"sulfoxide,":[120],"nitroblue":[121],"tetrazolium-positive":[122],"reach":[124],"approximately":[125],"90%":[126],"sulfoxide-induced":[132],"decreases":[140,155],"below":[141],"15%":[142],"5":[149],"as":[156],"well.":[157],"The":[158],"results":[159],"indicate":[160],"that":[161],"synthesis":[163],"is":[167],"linked":[168],"with":[169],"either":[170],"program.":[176]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}