{"id":"https://openalex.org/W2053463958","doi":"https://doi.org/10.1074/jbc.m406315200","title":"Regulation of Hepatitis C Virus Polyprotein Processing by Signal Peptidase Involves Structural Determinants at the p7 Sequence Junctions","display_name":"Regulation of Hepatitis C Virus Polyprotein Processing by Signal Peptidase Involves Structural Determinants at the p7 Sequence Junctions","publication_year":2004,"publication_date":"2004-07-09","ids":{"openalex":"https://openalex.org/W2053463958","doi":"https://doi.org/10.1074/jbc.m406315200","mag":"2053463958","pmid":"https://pubmed.ncbi.nlm.nih.gov/15247249"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m406315200","doi":"https://doi.org/10.1074/jbc.m406315200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m406315200","pdf_url":"http://www.jbc.org/article/S0021925820725974/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820725974/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086073176","display_name":"S\u00e9verine Carr\u00e8re\u2010Kremer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9verine Carr\u00e8re-Kremer","raw_affiliation_strings":["CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France","CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]},{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Claire Montpellier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Montpellier","raw_affiliation_strings":["CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039397864","display_name":"Lazaro Lorenzo","orcid":"https://orcid.org/0000-0001-6648-8684","observed_orcids":["https://orcid.org/0000-0001-6648-8684"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lazaro Lorenzo","raw_affiliation_strings":["CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026358475","display_name":"B\u00e9n\u00e9dicte Brulin","orcid":"https://orcid.org/0000-0001-6317-2879","observed_orcids":["https://orcid.org/0000-0001-6317-2879"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9n\u00e9dicte Brulin","raw_affiliation_strings":["CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045022092","display_name":"Laurence Cocquerel","orcid":"https://orcid.org/0000-0002-2136-5178","observed_orcids":["https://orcid.org/0000-0002-2136-5178"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Cocquerel","raw_affiliation_strings":["CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032860993","display_name":"Sandrine Belouzard","orcid":"https://orcid.org/0000-0002-9972-4054","observed_orcids":["https://orcid.org/0000-0002-9972-4054"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Belouzard","raw_affiliation_strings":["CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030252277","display_name":"Fran\u00e7ois P\u00e9nin","orcid":"https://orcid.org/0000-0003-0199-4396","observed_orcids":["https://orcid.org/0000-0003-0199-4396"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087293","display_name":"Institut de Biologie et de Chimie des Prot\u00e9ines","ror":"https://ror.org/0019x5d05","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210087293","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210095149","display_name":"Microbiologie mol\u00e9culaire et biochimie structurale","ror":"https://ror.org/00jv0wy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210095149","https://openalex.org/I4210096427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Penin","raw_affiliation_strings":["CNRS-UMR5086, IFR128 BioSciences Lyon-Gerland, Institut de Biologie et de Chimie des Prote\u0301ines, 69367 Lyon, France","CNRS-UMR5086, IFR128 BioSciences Lyon-Gerland, Institut de Biologie et de Chimie des Prot\u00e9ines, 69367 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UMR5086, IFR128 BioSciences Lyon-Gerland, Institut de Biologie et de Chimie des Prote\u0301ines, 69367 Lyon, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087293","https://openalex.org/I4210095149"]},{"raw_affiliation_string":"CNRS-UMR5086, IFR128 BioSciences Lyon-Gerland, Institut de Biologie et de Chimie des Prot\u00e9ines, 69367 Lyon, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087293","https://openalex.org/I4210095149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087727909","display_name":"Jean Dubuisson","orcid":"https://orcid.org/0000-0003-1626-7693","observed_orcids":["https://orcid.org/0000-0003-1626-7693"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean Dubuisson","raw_affiliation_strings":["CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UPR2511, Institut de Biologie de Lille, 59021 Lille, France and the","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087727909"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163910"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.0894,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.91036534,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"279","issue":"40","first_page":"41384","last_page":"41392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polyprotein-processing","display_name":"polyprotein processing","score":0.9070000052452087},{"id":"https://openalex.org/keywords/signal-peptidase","display_name":"signal peptidase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/p7","display_name":"p7","score":0.6710000038146973},{"id":"https://openalex.org/keywords/ns-2","display_name":"NS2","score":0.902999997138977},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cleavage-site","display_name":"cleavage site","score":0.5019999742507935},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.6660000085830688},{"id":"https://openalex.org/keywords/post-translational-processing","display_name":"post-translational processing","score":0.7269999980926514},{"id":"https://openalex.org/keywords/transmembrane-helices","display_name":"transmembrane helices","score":0.8209999799728394},{"id":"https://openalex.org/keywords/structural-factors","display_name":"structural factors","score":0.6840000152587891},{"id":"https://openalex.org/keywords/viral-protease","display_name":"viral protease","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C2779190341","wikidata":"https://www.wikidata.org/wiki/Q7512720","display_name":"Signal peptidase","level":5,"score":0.8019144535064697},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.755476713180542},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.7520445585250854},{"id":"https://openalex.org/C83100098","wikidata":"https://www.wikidata.org/wiki/Q106297070","display_name":"NS2-3 protease","level":4,"score":0.7491947412490845},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.6363495588302612},{"id":"https://openalex.org/C2781426373","wikidata":"https://www.wikidata.org/wiki/Q24766653","display_name":"NS5B","level":5,"score":0.6025872230529785},{"id":"https://openalex.org/C133672593","wikidata":"https://www.wikidata.org/wiki/Q5130990","display_name":"Cleavage factor","level":4,"score":0.5555737018585205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.530267596244812},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.49773457646369934},{"id":"https://openalex.org/C2777103181","wikidata":"https://www.wikidata.org/wiki/Q83141840","display_name":"NS5A","level":5,"score":0.47032320499420166},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.43091124296188354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3277170658111572},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32131484150886536},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.32096388936042786},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.31028932332992554},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3071022629737854},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.23908936977386475},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.1534450650215149},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15098491311073303},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0861654281616211},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086082","descriptor_name":"Viroporin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020815","descriptor_name":"Polyproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m406315200","doi":"https://doi.org/10.1074/jbc.m406315200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m406315200","pdf_url":"http://www.jbc.org/article/S0021925820725974/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15247249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15247249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00313687v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00313687","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, 2004, 279, pp.41384-41392","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m406315200","doi":"https://doi.org/10.1074/jbc.m406315200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m406315200","pdf_url":"http://www.jbc.org/article/S0021925820725974/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307875","display_name":"Styrelsen f\u00f6r Internationellt Utvecklingssamarbete","ror":"https://ror.org/01fn7me06"},{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053463958.pdf","grobid_xml":"https://content.openalex.org/works/W2053463958.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W52690854","https://openalex.org/W1512482605","https://openalex.org/W1562770137","https://openalex.org/W1635062911","https://openalex.org/W1763230925","https://openalex.org/W1911781239","https://openalex.org/W1933943651","https://openalex.org/W1970019795","https://openalex.org/W1970324388","https://openalex.org/W1974719543","https://openalex.org/W1978035722","https://openalex.org/W2003546739","https://openalex.org/W2005411001","https://openalex.org/W2015292449","https://openalex.org/W2021770060","https://openalex.org/W2022125636","https://openalex.org/W2022711087","https://openalex.org/W2024645073","https://openalex.org/W2027733213","https://openalex.org/W2030303541","https://openalex.org/W2030441312","https://openalex.org/W2038605297","https://openalex.org/W2040144236","https://openalex.org/W2045562270","https://openalex.org/W2047703023","https://openalex.org/W2050997685","https://openalex.org/W2057040842","https://openalex.org/W2060483294","https://openalex.org/W2064304037","https://openalex.org/W2070096641","https://openalex.org/W2071136569","https://openalex.org/W2078770660","https://openalex.org/W2078887917","https://openalex.org/W2083337563","https://openalex.org/W2098079636","https://openalex.org/W2106882534","https://openalex.org/W2108463852","https://openalex.org/W2116753660","https://openalex.org/W2123102587","https://openalex.org/W2125020009","https://openalex.org/W2126938436","https://openalex.org/W2138879032","https://openalex.org/W2151898297","https://openalex.org/W2152793674","https://openalex.org/W2160425277","https://openalex.org/W2162464744","https://openalex.org/W2165495076","https://openalex.org/W2171698623","https://openalex.org/W2767638256"],"related_works":["https://openalex.org/W1545947145","https://openalex.org/W2085637417","https://openalex.org/W2005406600","https://openalex.org/W1012607741","https://openalex.org/W2767237799","https://openalex.org/W2165834248","https://openalex.org/W2139172730","https://openalex.org/W1966256870","https://openalex.org/W3188075895","https://openalex.org/W2053463958"],"abstract_inverted_index":{"The":[0,79,193],"hepatitis":[1,41,230],"C":[2,42,231],"virus":[3,43,232],"genome":[4],"encodes":[5],"a":[6,58,98,127,196,223],"polyprotein":[7,44,224],"precursor":[8,45,225],"that":[9,126],"is":[10],"co-":[11],"and":[12,17,35,68,86,106,143,160,175,202,211,249],"post-translationally":[13,234],"processed":[14],"by":[15,57],"cellular":[16],"viral":[18],"proteases":[19],"to":[20,47,72,97,117,189,213,233],"yield":[21],"10":[22],"mature":[23,251],"protein":[24],"products":[25],"(C,":[26],"E1,":[27],"E2,":[28],"p7,":[29],"NS2,":[30],"NS3,":[31],"NS4A,":[32],"NS4B,":[33],"NS5A,":[34],"NS5B).":[36],"Although":[37],"most":[38],"cleavages":[39,55],"in":[40,219],"proceed":[46],"completion":[48],"during":[49],"or":[50,173],"immediately":[51,82],"after":[52],"translation,":[53],"the":[54,66,73,101,118,132,136,153,158,164,168,176,181,190,205,220,236,239],"mediated":[56],"host":[59],"cell":[60],"signal":[61,93,102,133],"peptidase":[62],"are":[63,226],"partial":[64,121,154],"at":[65,156],"E2/p7":[67,85,159,172],"p7/NS2":[69,87,139,161,174],"sites,":[70],"leading":[71],"production":[74],"of":[75,84,104,131,138,171,195,204,222,241,243],"an":[76],"E2p7NS2":[77],"precursor.":[78],"sequences":[80],"located":[81,129],"N-terminally":[83,130],"cleavage":[88,122,155,169,191,206,215],"sites":[89],"can":[90],"function":[91],"as":[92,245,247],"peptides.":[94],"When":[95],"fused":[96,116],"reporter":[99,119],"protein,":[100,120],"peptides":[103],"p7":[105,114,244],"NS2":[107,248],"were":[108],"efficiently":[109],"cleaved.":[110],"However,":[111],"when":[112],"full-length":[113],"was":[115,123],"observed,":[124],"indicating":[125],"sequence":[128,199],"peptide":[134],"reduces":[135],"efficiency":[137],"cleavage.":[140],"Sequence":[141],"analyses":[142],"mutagenesis":[144],"studies":[145],"have":[146],"also":[147],"identified":[148],"structural":[149,187],"determinants":[150],"responsible":[151],"for":[152,229],"both":[157],"sites.":[162,192],"Finally,":[163],"short":[165],"distance":[166],"between":[167,200],"site":[170,207],"predicted":[177],"transmembrane":[178],"alpha-helix":[179],"within":[180],"P'":[182],"region":[183],"might":[184],"impose":[185],"additional":[186],"constraints":[188,210,218],"insertion":[194],"linker":[197],"polypeptide":[198],"P-3'":[201],"P-4'":[203],"released":[208],"these":[209],"led":[212],"improved":[214],"efficiency.":[216],"Such":[217],"processing":[221],"likely":[227],"essential":[228],"regulate":[235],"kinetics":[237],"and/or":[238],"level":[240],"expression":[242],"well":[246],"E2":[250],"proteins.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}