{"id":"https://openalex.org/W2053463669","doi":"https://doi.org/10.1007/s00404-014-3264-y","title":"Construction of breast cancer gene regulatory networks and drug target optimization","display_name":"Construction of breast cancer gene regulatory networks and drug target optimization","publication_year":2014,"publication_date":"2014-06-02","ids":{"openalex":"https://openalex.org/W2053463669","doi":"https://doi.org/10.1007/s00404-014-3264-y","mag":"2053463669","pmid":"https://pubmed.ncbi.nlm.nih.gov/24890807"},"language":"en","primary_location":{"id":"doi:10.1007/s00404-014-3264-y","doi":"https://doi.org/10.1007/s00404-014-3264-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00404-014-3264-y","pdf_url":null,"source":{"id":"https://openalex.org/S568598","display_name":"Archives of Gynecology and Obstetrics","issn_l":"0003-9128","issn":["0003-9128","0170-9925","0932-0067","1432-0711"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Gynecology and Obstetrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114104204","display_name":"Yi-Shan Xie","orcid":"https://orcid.org/0000-0002-9811-0704","observed_orcids":["https://orcid.org/0000-0002-9811-0704"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yishan Xie","raw_affiliation_strings":["Department of Oncology, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuchan, 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuchan, 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431213","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0002-2284-9780","observed_orcids":["https://orcid.org/0000-0002-2284-9780"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["Department of Emergency, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuchan, 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuchan, 430060, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072763058","display_name":"Jian Zhu","orcid":"https://orcid.org/0000-0003-0171-4251","observed_orcids":["https://orcid.org/0000-0003-0171-4251"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Zhu","raw_affiliation_strings":["General Surgery Department, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang road 1665, Yangpu District, Shanghai, 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery Department, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang road 1665, Yangpu District, Shanghai, 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072763058"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.3663,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58070349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"290","issue":"4","first_page":"749","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.17960000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-target-genes","display_name":"drug target genes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pfkfb3","display_name":"PFKFB3","score":0.8330000042915344},{"id":"https://openalex.org/keywords/sirene","display_name":"Sirene","score":0.597000002861023},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7869199514389038},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6760132312774658},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5581108331680298},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.532765805721283},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5266408920288086},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5219601988792419},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4909122586250305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44753220677375793},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3656865060329437},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33509284257888794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3019229769706726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29515212774276733},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13179388642311096}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00404-014-3264-y","doi":"https://doi.org/10.1007/s00404-014-3264-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00404-014-3264-y","pdf_url":null,"source":{"id":"https://openalex.org/S568598","display_name":"Archives of Gynecology and Obstetrics","issn_l":"0003-9128","issn":["0003-9128","0170-9925","0932-0067","1432-0711"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Gynecology and Obstetrics","raw_type":"journal-article"},{"id":"pmid:24890807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24890807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of gynecology and obstetrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1596965334","https://openalex.org/W1966327575","https://openalex.org/W1967661140","https://openalex.org/W1979946545","https://openalex.org/W1984084871","https://openalex.org/W2009738798","https://openalex.org/W2025314771","https://openalex.org/W2027769492","https://openalex.org/W2031020671","https://openalex.org/W2044525257","https://openalex.org/W2050328564","https://openalex.org/W2055845643","https://openalex.org/W2057559260","https://openalex.org/W2058221907","https://openalex.org/W2072305554","https://openalex.org/W2076513103","https://openalex.org/W2078149659","https://openalex.org/W2096065464","https://openalex.org/W2105071916","https://openalex.org/W2120656656","https://openalex.org/W2132893003","https://openalex.org/W2139074343","https://openalex.org/W2146678343","https://openalex.org/W2154947819","https://openalex.org/W2155142785","https://openalex.org/W2161817637","https://openalex.org/W2163296115","https://openalex.org/W2163296727","https://openalex.org/W2167980479","https://openalex.org/W2169666080","https://openalex.org/W2256567217","https://openalex.org/W2322580055","https://openalex.org/W2348252013","https://openalex.org/W3099289621"],"related_works":["https://openalex.org/W4206379684","https://openalex.org/W2366105490","https://openalex.org/W2580680567","https://openalex.org/W4252292942","https://openalex.org/W4285170202","https://openalex.org/W114270996","https://openalex.org/W4249200654","https://openalex.org/W2396656278","https://openalex.org/W3011011760","https://openalex.org/W2407625558"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}