{"id":"https://openalex.org/W2053416840","doi":"https://doi.org/10.1097/00007890-199504150-00002","title":"ENHANCED TYPE 2 AND DIMINISHED TYPE 1 CYTOKINES IN NEONATAL TOLERANCE","display_name":"ENHANCED TYPE 2 AND DIMINISHED TYPE 1 CYTOKINES IN NEONATAL TOLERANCE","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W2053416840","doi":"https://doi.org/10.1097/00007890-199504150-00002","mag":"2053416840","pmid":"https://pubmed.ncbi.nlm.nih.gov/7535960"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199504150-00002","doi":"https://doi.org/10.1097/00007890-199504150-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199504150-00002","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088227833","display_name":"Naixi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naixi Chen","raw_affiliation_strings":["Department of Medicine, University of Iowa College of Medicine, Iowa City 52246, USA","Department of Medicine, University of Iowa College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Iowa College of Medicine, Iowa City 52246, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Medicine, University of Iowa College of Medicine","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039381470","display_name":"Elizabeth H. Field","orcid":"https://orcid.org/0000-0003-4043-7461","observed_orcids":["https://orcid.org/0000-0003-4043-7461"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth H. Field","raw_affiliation_strings":["Department of Medicine, University of Iowa College of Medicine","Department of Veterans Affairs Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Iowa College of Medicine","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.6387,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.97345339,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"59","issue":"7","first_page":"933","last_page":"941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-tolerance","display_name":"neonatal tolerance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.6150000095367432},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cytokine-profile","display_name":"cytokine profile","score":0.7419999837875366},{"id":"https://openalex.org/keywords/skin-graft-rejection","display_name":"skin graft rejection","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lymph-node-cells","display_name":"lymph node cells","score":0.48899999260902405},{"id":"https://openalex.org/keywords/transplantation-tolerance","display_name":"transplantation tolerance","score":0.3700000047683716},{"id":"https://openalex.org/keywords/cytokine-therapy","display_name":"cytokine therapy","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.7585930824279785},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6859630346298218},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.656006932258606},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.6522985100746155},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6062043309211731},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5863174200057983},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.5269561409950256},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.5228362679481506},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5117278099060059},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5097927451133728},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4736151397228241},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.45325547456741333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.412394255399704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3549172282218933},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30148959159851074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2337593138217926},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008805","descriptor_name":"Mice, Inbred A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199504150-00002","doi":"https://doi.org/10.1097/00007890-199504150-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199504150-00002","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:7535960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7535960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3715601035","display_name":null,"funder_award_id":"CA-45541","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G643643319","display_name":null,"funder_award_id":"DK25295-15","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7567427","display_name":"CORE CENTER--DIABETES AND ENDOCRINOLOGY","funder_award_id":"P30DK025295","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979874886","https://openalex.org/W2035876896","https://openalex.org/W2087640426","https://openalex.org/W1998772929","https://openalex.org/W2058062220","https://openalex.org/W1978994352","https://openalex.org/W4313376250","https://openalex.org/W2099374707","https://openalex.org/W1905147935","https://openalex.org/W1504356233"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,11,24,119,130,141,153,184,211],"cytokine":[3,62,158],"profiles":[4],"associated":[5],"with":[6,20],"tolerance":[7,205],"and":[8,37,68,94,206],"rejection":[9],"using":[10],"mouse":[12],"model":[13,198],"of":[14,33,126,160,187,199,204,214],"neonatal":[15,25,121,147,164],"tolerance.":[16],"BALB/c":[17],"mice":[18,58,102,149,166],"primed":[19,148,165],"CAF1":[21],"splenocytes":[22],"during":[23,118,138],"stage":[26,122],"showed":[27],"increased":[28],"A/J":[29,54,85],"skin":[30],"graft":[31],"survival":[32],">":[34],"60":[35],"days":[36],"failed":[38],"to":[39,105,110,152,170],"develop":[40],"anti-A/J":[41],"cytotoxic":[42],"responses,":[43],"but":[44],"rejected":[45,80,84],"third-party":[46,81],"C57BL/6":[47],"grafts.":[48],"Lymph":[49],"node":[50,75],"cells":[51,76],"that":[52,77,183],"drained":[53,78],"grafts":[55,82,86],"on":[56,88],"neonatal-primed":[57,101],"produced":[59,91],"allospecific":[60],"immune":[61,98],"responses":[63,99],"characterized":[64],"by":[65],"high":[66],"IL-4":[67,93,109,127,144],"low":[69],"IFN-gamma":[70,111,133],"levels.":[71],"In":[72],"contrast,":[73],"lymph":[74],"either":[79],"or":[83],"placed":[87],"adult":[89],"controls":[90],"less":[92],"more":[95],"IFN-gamma.":[96],"Tolerogen-specific":[97],"from":[100,146],"made":[103],"up":[104,169],"100":[106],"times":[107],"higher":[108],"ratios":[112],"than":[113],"did":[114],"controls.":[115],"Alloantigen":[116],"priming":[117,174],"immediate":[120],"induced":[123,140],"constitutive":[124],"expression":[125],"mRNA":[128],"in":[129,163,175,176,216],"spleen":[131],"without":[132],"mRNA,":[134],"whereas":[135],"alloantigen":[136],"stimulation":[137,189],"adulthood":[139],"opposite":[142],"pattern.":[143],"production":[145],"was":[150],"confined":[151],"CD4":[154,192],"population.":[155],"The":[156,194],"altered":[157],"profile":[159],"enhanced":[161],"IL-4/IFN-gamma":[162],"persisted":[167],"for":[168,209],"12":[171],"weeks":[172],"after":[173],"vitro":[177],"secondary":[178],"MLR":[179],"assays,":[180],"which":[181],"suggests":[182],"initial":[185],"timing":[186],"antigen":[188],"critically":[190],"influenced":[191],"maturation.":[193],"results":[195],"support":[196],"a":[197,202],"immunoredirection":[200],"as":[201],"mechanism":[203],"provide":[207],"rationale":[208],"examining":[210],"therapeutic":[212],"use":[213],"cytokines":[215],"transplantation.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}