{"id":"https://openalex.org/W2053317293","doi":"https://doi.org/10.2147/dddt.s66574","title":"Involvement of NF-\u039aB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, \u03b1-mangostin, from Cratoxylum arborescens","display_name":"Involvement of NF-\u039aB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, \u03b1-mangostin, from Cratoxylum arborescens","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2053317293","doi":"https://doi.org/10.2147/dddt.s66574","mag":"2053317293","pmid":"https://pubmed.ncbi.nlm.nih.gov/25395836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4227646"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s66574","doi":"https://doi.org/10.2147/dddt.s66574","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s66574","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/dddt.s66574","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072143960","display_name":"Mohamed Yousif Ibrahim","orcid":"https://orcid.org/0000-0003-3752-9154","observed_orcids":["https://orcid.org/0000-0003-3752-9154"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohamed Yousif Ibrahim","raw_affiliation_strings":["Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109280351","display_name":"Hapipah Mohd Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Hapipah Mohd Ali","raw_affiliation_strings":["Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103285205","display_name":"Najihah Mohd Hashim","orcid":"https://orcid.org/0000-0003-1133-7998","observed_orcids":["https://orcid.org/0000-0003-1133-7998"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Najihah Mohd Hashim","raw_affiliation_strings":["Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108080700","display_name":"Syam Mohan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Syam Mohan","raw_affiliation_strings":["Medical Research Centre, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Centre, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012179237","display_name":"Siddig \u0130brahim Abdelwahab","orcid":"https://orcid.org/0000-0002-6145-4466","observed_orcids":["https://orcid.org/0000-0002-6145-4466"]},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Siddig Ibrahim Abdelwahab","raw_affiliation_strings":["Medical Research Centre, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Centre, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024319319","display_name":"Behnam Kamal\u0131dehghan","orcid":"https://orcid.org/0000-0001-8530-8124","observed_orcids":["https://orcid.org/0000-0001-8530-8124"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Behnam Kamalidehghan","raw_affiliation_strings":["Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014047178","display_name":"Mostafa Ghaderian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mostafa Ghaderian","raw_affiliation_strings":["Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ; Epigenetics Lab, HIR Building, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ; Epigenetics Lab, HIR Building, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087885064","display_name":"Firouzeh Dehghan","orcid":"https://orcid.org/0000-0002-6460-7528","observed_orcids":["https://orcid.org/0000-0002-6460-7528"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Firouzeh Dehghan","raw_affiliation_strings":["Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ; Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ; Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021830401","display_name":"Landa Zeenelabdin Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Landa Zeenelabdin Ali","raw_affiliation_strings":["Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089764779","display_name":"Hamed Karimian","orcid":"https://orcid.org/0000-0002-8501-9864","observed_orcids":["https://orcid.org/0000-0002-8501-9864"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Hamed Karimian","raw_affiliation_strings":["Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068418406","display_name":"Maizatulakmal Yahayu","orcid":"https://orcid.org/0000-0002-2373-5267","observed_orcids":["https://orcid.org/0000-0002-2373-5267"]},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Maizatulakmal Yahayu","raw_affiliation_strings":["Department of Bioproduct Research and Innovation, Institute of Bioproduct Development (IBD), Universiti Teknologi Malaysia, UTM Johor Bahru, Johor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioproduct Research and Innovation, Institute of Bioproduct Development (IBD), Universiti Teknologi Malaysia, UTM Johor Bahru, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008458634","display_name":"Gwendoline Ee Cheng Lian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Gwendoline Ee Cheng Lian","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052046197","display_name":"Mahmood Ameen Abdulla","orcid":"https://orcid.org/0009-0008-5390-8502","observed_orcids":["https://orcid.org/0009-0008-5390-8502"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mahmood Ameen Abdulla","raw_affiliation_strings":["Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069925747","display_name":"Abdoreza Soleimani Farjam","orcid":"https://orcid.org/0000-0002-7637-0556","observed_orcids":["https://orcid.org/0000-0002-7637-0556"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Abdoreza Soleimani Farjam","raw_affiliation_strings":["Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), Serdang, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), Serdang, Selangor, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":3.9412,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.92475156,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":null,"first_page":"2193","last_page":"2193"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-mangostin","display_name":"\u03b1-mangostin","score":0.984000027179718},{"id":"https://openalex.org/keywords/cratoxylum-arborescens","display_name":"Cratoxylum arborescens","score":0.996999979019165},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8600000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8989999890327454},{"id":"https://openalex.org/keywords/prenylated-xanthones","display_name":"prenylated xanthones","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.597000002861023},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9800000190734863},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.8920000195503235},{"id":"https://openalex.org/keywords/caspase-3-7","display_name":"caspase 3/7","score":0.8980000019073486},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bcl-2-bax","display_name":"Bcl-2/Bax","score":0.8009999990463257},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9020000100135803},{"id":"https://openalex.org/keywords/s-phase-arrest","display_name":"S phase arrest","score":0.8510000109672546},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.691127359867096},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.599609911441803},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.5874522924423218},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.5610584020614624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5415345430374146},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5042351484298706},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.5029365420341492},{"id":"https://openalex.org/C155878803","wikidata":"https://www.wikidata.org/wiki/Q5205755","display_name":"DNA laddering","level":5,"score":0.48163145780563354},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4781442880630493},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4777849614620209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33795422315597534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2571914792060852},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.20563200116157532}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D028084","descriptor_name":"Clusiaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/dddt.s66574","doi":"https://doi.org/10.2147/dddt.s66574","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s66574","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3199107","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4227646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25395836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25395836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4227646","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4227646/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:343f244a282d4a18861cca948a53fa3c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/343f244a282d4a18861cca948a53fa3c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol 2014, Iss default, Pp 2193-2211 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s66574","doi":"https://doi.org/10.2147/dddt.s66574","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s66574","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1508463584","https://openalex.org/W1618299283","https://openalex.org/W1639770975","https://openalex.org/W1805030384","https://openalex.org/W1965694039","https://openalex.org/W1969039566","https://openalex.org/W1969582246","https://openalex.org/W1970101659","https://openalex.org/W1982415074","https://openalex.org/W1987432765","https://openalex.org/W1988226309","https://openalex.org/W1992476369","https://openalex.org/W1995614441","https://openalex.org/W1997005119","https://openalex.org/W1998063573","https://openalex.org/W2005112594","https://openalex.org/W2006644088","https://openalex.org/W2006966362","https://openalex.org/W2008014318","https://openalex.org/W2008757142","https://openalex.org/W2008757158","https://openalex.org/W2012568649","https://openalex.org/W2016223517","https://openalex.org/W2016314326","https://openalex.org/W2016410319","https://openalex.org/W2022145079","https://openalex.org/W2028003944","https://openalex.org/W2034937845","https://openalex.org/W2039431907","https://openalex.org/W2039724668","https://openalex.org/W2039817035","https://openalex.org/W2040059581","https://openalex.org/W2040217028","https://openalex.org/W2043425993","https://openalex.org/W2044389093","https://openalex.org/W2045716810","https://openalex.org/W2047409050","https://openalex.org/W2050011732","https://openalex.org/W2051107237","https://openalex.org/W2052842511","https://openalex.org/W2054537850","https://openalex.org/W2057439779","https://openalex.org/W2057584177","https://openalex.org/W2059373592","https://openalex.org/W2060056009","https://openalex.org/W2066489978","https://openalex.org/W2073865298","https://openalex.org/W2074919046","https://openalex.org/W2085408082","https://openalex.org/W2086574675","https://openalex.org/W2088154315","https://openalex.org/W2089569798","https://openalex.org/W2094666346","https://openalex.org/W2096563333","https://openalex.org/W2099213197","https://openalex.org/W2099474680","https://openalex.org/W2106035942","https://openalex.org/W2109453910","https://openalex.org/W2109748156","https://openalex.org/W2113455273","https://openalex.org/W2118299978","https://openalex.org/W2123513769","https://openalex.org/W2124848053","https://openalex.org/W2127582739","https://openalex.org/W2134295452","https://openalex.org/W2147539574","https://openalex.org/W2147954573","https://openalex.org/W2150048195","https://openalex.org/W2151832198","https://openalex.org/W2152596116","https://openalex.org/W2153155740","https://openalex.org/W2153622155","https://openalex.org/W2154894590","https://openalex.org/W2158448236","https://openalex.org/W2159707911","https://openalex.org/W2160723825","https://openalex.org/W2161817637","https://openalex.org/W2165453779","https://openalex.org/W2167490100","https://openalex.org/W2168601768"],"related_works":["https://openalex.org/W2080846998","https://openalex.org/W7001351513","https://openalex.org/W7097025065","https://openalex.org/W2767504181","https://openalex.org/W2124099438","https://openalex.org/W2738220275","https://openalex.org/W2076414466","https://openalex.org/W2099213197","https://openalex.org/W7006568895","https://openalex.org/W2096563333"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cratoxylum":[1],"arborescens":[2,22,257],"has":[3],"been":[4],"used":[5,48,60],"traditionally":[6],"in":[7,52,139,142,218],"Malaysia":[8],"for":[9],"the":[10,35,63,98,101,115,130,169,172,179,185,191,198,207,210,229,237,248,252,259,280,289],"treatment":[11,204],"of":[12,55,77,100,117,145,158,162,181,195,200,231,240,261,288],"various":[13],"ailments.":[14],"METHODS:":[15],"\u03b1-Mangostin":[16],"(AM)":[17],"was":[18,28,32,59,112,122,127,274],"isolated":[19,254],"from":[20,168,242,255],"C.":[21,256],"and":[23,44,71,80,86,89,137,160,188,225,269,282,291],"its":[24],"cell":[25,66,90,150,266,271],"death":[26],"mechanism":[27],"investigated.":[29,95],"AM-induced":[30],"cytotoxicity":[31],"observed":[33],"with":[34,134,147,215,286],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[36],"bromide":[37],"(MTT)":[38],"assay.":[39],"Acridine":[40],"orange/propidium":[41],"iodide":[42],"staining":[43],"annexin":[45,135],"V":[46,136],"were":[47,93],"to":[49,61,171,244,265,276],"detect":[50],"cells":[51,132,146,208],"early":[53],"phases":[54],"apoptosis.":[56],"High-content":[57],"screening":[58],"observe":[62],"nuclear":[64,118],"condensation,":[65],"permeability,":[67],"mitochondrial":[68],"membrane":[69],"potential,":[70],"cytochrome":[72,165,176],"c":[73,166,177],"release.":[74],"The":[75,174,222],"role":[76,99],"caspases-3/7,":[78],"-8,":[79],"-9,":[81],"reactive":[82,219],"oxygen":[83,220],"species,":[84],"Bcl-2":[85,159],"Bax":[87],"expression,":[88],"cycle":[91,267],"arrest":[92,268],"also":[94,123],"To":[96],"determine":[97],"central":[102],"apoptosis-related":[103],"proteins,":[104],"a":[105],"protein":[106,223],"array":[107,224],"followed":[108,183],"by":[109,129,156,184],"immunoblot":[110],"analysis":[111],"conducted.":[113],"Moreover,":[114,233],"involvement":[116,199,287],"factor-kappa":[119],"B":[120],"(NF-\u03baB)":[121],"analyzed.":[124],"RESULTS:":[125],"Apoptosis":[126],"confirmed":[128],"apoptotic":[131],"stained":[133],"increase":[138,217],"chromatin":[140],"condensation":[141],"nucleus.":[143,245],"Treatment":[144],"AM":[148,203,234,253],"promoted":[149],"death-transducing":[151],"signals":[152],"that":[153,251],"reduced":[154],"MMP":[155],"downregulation":[157],"upregulation":[161],"Bax,":[163],"triggering":[164],"release":[167],"mitochondria":[170],"cytosol.":[173],"released":[175],"triggered":[178],"activation":[180],"caspase-9":[182],"executioner":[186],"caspase-3/7":[187],"then":[189],"cleaved":[190],"PARP":[192],"protein.":[193],"Increase":[194],"caspase-8":[196],"showed":[197],"extrinsic":[201,281],"pathway.":[202],"significantly":[205,235],"arrested":[206],"at":[209],"S":[211],"phase":[212],"(P<0.05)":[213],"concomitant":[214],"an":[216],"species.":[221],"Western":[226],"blotting":[227],"demonstrated":[228],"expression":[230],"HSP70.":[232],"blocked":[236],"induced":[238],"translocation":[239],"NF-\u03baB":[241,290],"cytoplasm":[243],"CONCLUSION:":[246],"Together,":[247],"results":[249],"demonstrate":[250],"inhibited":[258],"proliferation":[260],"MDA-MB-231":[262],"cells,":[263],"leading":[264],"programmed":[270],"death,":[272],"which":[273],"suggested":[275],"occur":[277],"through":[278],"both":[279],"intrinsic":[283],"apoptosis":[284],"pathways":[285],"HSP70":[292],"signaling":[293],"pathways.":[294]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}