{"id":"https://openalex.org/W205327552","doi":"https://doi.org/10.1096/fasebj.21.6.a1278-c","title":"Whole\u2010body hypoxic preconditioning (WHPC) prolongs survival in experimentally\u2010induced lethal hemorrhagic shock in rats","display_name":"Whole\u2010body hypoxic preconditioning (WHPC) prolongs survival in experimentally\u2010induced lethal hemorrhagic shock in rats","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W205327552","doi":"https://doi.org/10.1096/fasebj.21.6.a1278-c","mag":"205327552"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1278-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1278-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1278-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090599864","display_name":"Maja Skikic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maja Skikic","raw_affiliation_strings":["Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102057170","display_name":"Shang Zhi Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shang Z Guo","raw_affiliation_strings":["Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052547029","display_name":"Stephen R. Reeves","orcid":"https://orcid.org/0000-0002-8552-6022","observed_orcids":["https://orcid.org/0000-0002-8552-6022"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R Reeves","raw_affiliation_strings":["Pharmacology and Toxicology, University of Louisville, 570 South Preston Street, KCHRI, Louisville, KY, 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, University of Louisville, 570 South Preston Street, KCHRI, Louisville, KY, 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113641605","display_name":"James J. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210143137","display_name":"University of Louisville Hospital","ror":"https://ror.org/04sq8k219","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143137"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J Miller","raw_affiliation_strings":["Pathology and Laboratory Medicine, University of Louisville, 530 South Jackson Street, University Hospital, Louisville, KY, 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, University of Louisville, 530 South Jackson Street, University Hospital, Louisville, KY, 40202","institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210143137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043623030","display_name":"David Gozal","orcid":"https://orcid.org/0000-0001-8195-6036","observed_orcids":["https://orcid.org/0000-0001-8195-6036"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gozal","raw_affiliation_strings":["Pediatrics","Pharmacology and Toxicology, University of Louisville, 570 South Preston Street, KCHRI, Louisville, KY, 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics","institution_ids":[]},{"raw_affiliation_string":"Pharmacology and Toxicology, University of Louisville, 570 South Preston Street, KCHRI, Louisville, KY, 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100322879","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0003-0842-2446","observed_orcids":["https://orcid.org/0000-0003-0842-2446","https://orcid.org/0009-0003-0019-8264","https://orcid.org/0000-0002-3562-0264"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Pediatrics","Pharmacology and Toxicology, University of Louisville, 570 South Preston Street, KCHRI, Louisville, KY, 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics","institution_ids":[]},{"raw_affiliation_string":"Pharmacology and Toxicology, University of Louisville, 570 South Preston Street, KCHRI, Louisville, KY, 40202","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03021056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.9879999756813049},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5080000162124634},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/organ-damage","display_name":"organ damage","score":0.7609999775886536},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tissue-perfusion","display_name":"tissue perfusion","score":0.9670000076293945},{"id":"https://openalex.org/keywords/blood-loss","display_name":"blood loss","score":0.5260000228881836},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6620000004768372},{"id":"https://openalex.org/keywords/base-excess","display_name":"base excess","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hypoxic-preconditioning","display_name":"hypoxic preconditioning","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7012519240379333},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.692766010761261},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.660694420337677},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.6354597210884094},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5904351472854614},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.5651625394821167},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5475184321403503},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.5144117474555969},{"id":"https://openalex.org/C2993366118","wikidata":"https://www.wikidata.org/wiki/Q1320276","display_name":"Hemorrhagic shock","level":3,"score":0.5065096616744995},{"id":"https://openalex.org/C86257020","wikidata":"https://www.wikidata.org/wiki/Q809826","display_name":"Base excess","level":2,"score":0.46883338689804077},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44341447949409485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4059741497039795},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34639859199523926},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15062680840492249},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.11938965320587158},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1278-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1278-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1278-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009169942","https://openalex.org/W2027124128","https://openalex.org/W7098240916","https://openalex.org/W2362991213","https://openalex.org/W3000419006","https://openalex.org/W2412916223","https://openalex.org/W2024373369","https://openalex.org/W3003355939","https://openalex.org/W1997267372","https://openalex.org/W2370778699"],"abstract_inverted_index":{"WHPC":[0,24,89,136,189,204],"extends":[1],"the":[2,62,155],"survival":[3,28],"of":[4,17,41,43,64,85,92,158,168],"mice":[5],"exposed":[6],"to":[7,31,39,151],"lethal":[8],"environmental":[9],"hypoxia":[10],"by":[11],"preserving":[12],"structural":[13],"and":[14,67,77,112,117,165,184],"functional":[15],"integrity":[16],"key":[18,169],"organs.":[19],"We":[20,53,201],"now":[21],"examined":[22],"whether":[23],"would":[25],"also":[26],"prolong":[27],"in":[29,126,132,144],"response":[30],"hemorrhagic":[32,212],"shock.":[33,213],"Conscious":[34],"male":[35],"rats":[36,57,86],"were":[37],"subjected":[38],"bleeding":[40,65,103,125,194],"60%":[42],"their":[44],"estimated":[45],"blood":[46,160,179],"volume":[47],"(~37.2":[48],"ml/kg)":[49],"over":[50],"30":[51],"min.":[52],"found":[54],"that":[55,203],"na\u00efve":[56],"died":[58],"76\u00b19":[59],"min":[60],"after":[61],"completion":[63],"(n=15)":[66],"this":[68],"process":[69],"was":[70,137,195],"associated":[71,196],"with":[72,88,135,162,197],"progressively":[73],"increasing":[74],"metabolic":[75],"acidosis":[76,116],"cell/organ":[78,118],"injury.":[79,119],"In":[80],"contrast,":[81],"more":[82],"than":[83],"80%":[84],"treated":[87,134],"(6":[90],"cycles":[91],"8%":[93],"O":[94,97,129],"2":[95,98,100,130],"x10\u2010min/21%":[96],"x10\u2010min)":[99],"h":[101,106,192],"before":[102,193],"survived":[104],">6":[105],"without":[107],"fluid":[108],"resuscitation":[109],"(n=14,":[110],"p<0.001)":[111],"displayed":[113],"significantly":[114,138],"reduced":[115],"Although":[120],"it":[121],"decreased":[122],"drastically":[123],"following":[124],"all":[127],"rats,":[128],"consumption":[131],"those":[133],"higher,":[139],"suggesting":[140],"better":[141],"tissue":[142],"perfusion":[143],"these":[145],"animals.":[146],"Furthermore,":[147],"surviving":[148],"animals":[149],"appeared":[150],"be":[152],"recovering":[153],"from":[154],"initial":[156],"impact":[157],"massive":[159],"loss,":[161],"accelerated":[163],"compensation":[164],"sustained":[166],"maintenance":[167],"variables":[170],"above":[171],"critical":[172],"levels":[173],"(mean":[174],"arterial":[175],"pressure":[176],">60":[177],"mmHg,":[178],"base":[180],"excess":[181],">\u22126":[182],"mmol/L,":[183],"plasma":[185],"lactate":[186],"<5":[187],"mmol/L).":[188],"treatment":[190],"8":[191],"similar":[198],"beneficial":[199],"effects.":[200],"conclude":[202],"provides":[205],"a":[206],"robust":[207],"protective":[208],"mechanism":[209],"against":[210],"acute":[211]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
