{"id":"https://openalex.org/W2053205239","doi":"https://doi.org/10.1164/ajrccm.149.2.8306040","title":"Pulmonary Vascular Abnormalities and Ventilation-Perfusion Relationships in Mild Chronic Obstructive Pulmonary Disease","display_name":"Pulmonary Vascular Abnormalities and Ventilation-Perfusion Relationships in Mild Chronic Obstructive Pulmonary Disease","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2053205239","doi":"https://doi.org/10.1164/ajrccm.149.2.8306040","mag":"2053205239","pmid":"https://pubmed.ncbi.nlm.nih.gov/8306040"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.149.2.8306040","doi":"https://doi.org/10.1164/ajrccm.149.2.8306040","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.149.2.8306040","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002527277","display_name":"Joan Albert Barber\u00e0","orcid":"https://orcid.org/0000-0003-1469-4990","observed_orcids":["https://orcid.org/0000-0003-1469-4990"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J A Barber\u00e0","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058417596","display_name":"Ana Riverola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Riverola","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042593224","display_name":"Josep Roca","orcid":"https://orcid.org/0000-0003-4768-8722","observed_orcids":["https://orcid.org/0000-0003-4768-8722"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J Roca","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002837239","display_name":"Jos\u00e9 Ram\u00edrez","orcid":"https://orcid.org/0000-0002-7833-1374","observed_orcids":["https://orcid.org/0000-0002-7833-1374"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J Ramirez","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018377081","display_name":"Peter D. Wagner","orcid":"https://orcid.org/0000-0001-7957-7432","observed_orcids":["https://orcid.org/0000-0001-7957-7432"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P D Wagner","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033596904","display_name":"Dom\u00e8nec Ros","orcid":"https://orcid.org/0000-0003-3131-9017","observed_orcids":["https://orcid.org/0000-0003-3131-9017"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D Ros","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108483915","display_name":"B. R. Wiggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B R Wiggs","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110413692","display_name":"R. Rodr\u00edguez-Roisin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R Rodriguez-Roisin","raw_affiliation_strings":["Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Servei de Pneumologia), Hospital Cl\u00ednic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115097"],"apc_list":null,"apc_paid":null,"fwci":5.4444,"has_fulltext":false,"cited_by_count":256,"citation_normalized_percentile":{"value":0.95948885,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"149","issue":"2","first_page":"423","last_page":"429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pulmonary-vascular-anomalies","display_name":"pulmonary vascular abnormalities","score":0.7009999752044678},{"id":"https://openalex.org/keywords/ventilation-perfusion-mismatch","display_name":"ventilation-perfusion mismatch","score":0.9300000071525574},{"id":"https://openalex.org/keywords/intimal-thickening","display_name":"intimal thickening","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pulmonary-vascular-tone","display_name":"pulmonary vascular tone","score":0.656000018119812},{"id":"https://openalex.org/keywords/arterial-wall-thickening","display_name":"arterial wall thickening","score":0.6610000133514404},{"id":"https://openalex.org/keywords/mild-copd","display_name":"mild COPD","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9209109544754028},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7141656875610352},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6633122563362122},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5636045336723328},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.5572623014450073},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5477832555770874},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.48934000730514526},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.4692017436027527},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014692","descriptor_name":"Ventilation-Perfusion Ratio","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm.149.2.8306040","doi":"https://doi.org/10.1164/ajrccm.149.2.8306040","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.149.2.8306040","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},{"id":"pmid:8306040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8306040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1247005325","https://openalex.org/W1581836002","https://openalex.org/W1787652680","https://openalex.org/W1903842282","https://openalex.org/W1909329388","https://openalex.org/W1946257617","https://openalex.org/W1965237664","https://openalex.org/W1969877675","https://openalex.org/W1990951749","https://openalex.org/W2015914562","https://openalex.org/W2031234213","https://openalex.org/W2038161096","https://openalex.org/W2053478869","https://openalex.org/W2055372038","https://openalex.org/W2063529579","https://openalex.org/W2072530516","https://openalex.org/W2075691238","https://openalex.org/W2079648278","https://openalex.org/W2090735786","https://openalex.org/W2110817651","https://openalex.org/W2112964774","https://openalex.org/W2121519429","https://openalex.org/W2124873041","https://openalex.org/W2133936382","https://openalex.org/W2140377941","https://openalex.org/W2153759044","https://openalex.org/W2163426512","https://openalex.org/W2220862514","https://openalex.org/W2341304214","https://openalex.org/W2394860824","https://openalex.org/W2400715111","https://openalex.org/W2416446586","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1990951749","https://openalex.org/W93596098","https://openalex.org/W2072530516","https://openalex.org/W2343934094","https://openalex.org/W1973031417","https://openalex.org/W2132423236","https://openalex.org/W2009936947","https://openalex.org/W2038161096","https://openalex.org/W2379064833","https://openalex.org/W2011392930"],"abstract_inverted_index":{"Morphologic":[0],"changes":[1,60,166],"in":[2,25,61,91,149,161,181,185,203,205,211],"pulmonary":[3,13,30,41],"muscular":[4,42],"arteries":[5,43,148,212],"may":[6],"modify":[7],"the":[8,12,35,38,45,53,59,83,89,174,201,229,239],"mechanisms":[9],"that":[10,200],"regulate":[11],"vascular":[14],"tone":[15],"and":[16,44,50,88,119,130,136,152,157,177,238],"contribute":[17],"to":[18,51,82,123,140],"maintaining":[19],"an":[20,171],"adequate":[21],"ventilation-perfusion":[22],"(VA/Q)":[23],"matching":[24],"patients":[26,73,102,109,115,132],"with":[27,74,110,116,133,213,227],"chronic":[28],"obstructive":[29],"disease":[31],"(COPD).":[32],"To":[33],"analyze":[34],"relationships":[36,63],"between":[37],"abnormalities":[39,57],"of":[40,47,55,72,85,173,190,196,242],"degree":[46,84],"VA/Q":[48,62,92,243],"inequality,":[49],"assess":[52],"effect":[54],"these":[56],"on":[58,223],"induced":[64],"by":[65,95,170],"oxygen":[66,124,141],"breathing,":[67],"we":[68],"studied":[69],"a":[70,120,137,194],"group":[71],"mild":[75],"COPD":[76],"undergoing":[77],"resective":[78],"lung":[79,112],"surgery.":[80],"According":[81],"airflow":[86,117,134],"obstruction":[87,118,135],"increase":[90,202],"mismatch":[93],"produced":[94,168],"100%":[96],"O2":[97],"breathing":[98],"(delta":[99,125,142],"logSD":[100,126,143],"Q),":[101],"were":[103,167,178],"divided":[104],"into":[105],"three":[106],"groups:":[107],"(A)":[108],"normal":[111],"function,":[113],"(B)":[114],"high":[121],"response":[122,139],"Q":[127,144],">":[128],"0.4),":[129],"(C)":[131],"low":[138],"<":[145,236,249],"0.4).":[146],"Pulmonary":[147],"Groups":[150],"B":[151],"C":[153,183,207],"showed":[154,199],"narrower":[155],"lumens":[156],"thicker":[158],"walls":[159],"than":[160,184],"Group":[162,182,186,206],"A.":[163],"These":[164],"morphologic":[165],"mainly":[169],"enlargement":[172],"intimal":[175,191,221],"layer":[176],"more":[179],"pronounced":[180],"B.":[187],"The":[188,219],"assessment":[189],"area":[192,222],"as":[193],"function":[195],"artery":[197],"diameter":[198],"intima":[204],"took":[208],"place":[209],"predominantly":[210],"small":[214],"diameters":[215],"(<":[216],"500":[217],"microns).":[218],"mean":[220],"each":[224],"subject":[225],"correlated":[226],"both":[228],"PaO2":[230],"value":[231],"(r":[232,245],"=":[233,246],"-0.46,":[234],"p":[235,248],"0.05)":[237],"overall":[240],"index":[241],"mismatching":[244],"0.51,":[247],"0.05).(ABSTRACT":[250],"TRUNCATED":[251],"AT":[252],"250":[253],"WORDS)":[254]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
