{"id":"https://openalex.org/W2053193232","doi":"https://doi.org/10.1371/journal.pone.0080445","title":"Association between HLA Variations and Chronic Hepatitis B Virus Infection in Saudi Arabian Patients","display_name":"Association between HLA Variations and Chronic Hepatitis B Virus Infection in Saudi Arabian Patients","publication_year":2014,"publication_date":"2014-01-22","ids":{"openalex":"https://openalex.org/W2053193232","doi":"https://doi.org/10.1371/journal.pone.0080445","mag":"2053193232","pmid":"https://pubmed.ncbi.nlm.nih.gov/24465366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3898905"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0080445","doi":"https://doi.org/10.1371/journal.pone.0080445","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0080445","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080445&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080445&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076853480","display_name":"Ahmed Ali Al-Qahtani","orcid":"https://orcid.org/0000-0003-4584-5739","observed_orcids":["https://orcid.org/0000-0003-4584-5739"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]},{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Ahmed A. Al-Qahtani","raw_affiliation_strings":["Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796","https://openalex.org/I28022161"]},{"raw_affiliation_string":"Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]},{"raw_affiliation_string":"Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111696995","display_name":"Mashael R. Al\u2010Anazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mashael R. Al-Anazi","raw_affiliation_strings":["Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109862684","display_name":"Ayman A. Abdo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ayman A. Abdo","raw_affiliation_strings":["Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058815535","display_name":"Faisal M. Sanai","orcid":"https://orcid.org/0000-0002-3830-9236","observed_orcids":["https://orcid.org/0000-0002-3830-9236"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]},{"id":"https://openalex.org/I2802517405","display_name":"King Abdulaziz Medical City","ror":"https://ror.org/009djsq06","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2802517405"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Faisal M. Sanai","raw_affiliation_strings":["Hepatobiliary Sciences and Liver Transplantation, King Abdulaziz Medical City, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Hepatobiliary Sciences and Liver Transplantation, King Abdulaziz Medical City, Riyadh, Saudi Arabia","Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Sciences and Liver Transplantation, King Abdulaziz Medical City, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161","https://openalex.org/I2802517405"]},{"raw_affiliation_string":"Hepatobiliary Sciences and Liver Transplantation, King Abdulaziz Medical City, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2802517405"]},{"raw_affiliation_string":"Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038898216","display_name":"Waleed Al-hamoudi","orcid":"https://orcid.org/0000-0002-2759-0894","observed_orcids":["https://orcid.org/0000-0002-2759-0894"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Waleed Al-Hamoudi","raw_affiliation_strings":["Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090751447","display_name":"Khalid Alswat","orcid":"https://orcid.org/0000-0002-3521-8523","observed_orcids":["https://orcid.org/0000-0002-3521-8523"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Khalid A. Alswat","raw_affiliation_strings":["Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia ; Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Section of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108285104","display_name":"Hamad Ibrahim Al-Ashgar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hamad I. Al-Ashgar","raw_affiliation_strings":["Department of Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045247076","display_name":"Nisreen Z. Khalaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nisreen Z. Khalaf","raw_affiliation_strings":["Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114025386","display_name":"Abdelmoneim Eldali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdelmoneim M. Eldali","raw_affiliation_strings":["Department of Biostatistics, Epidemiology & Scientific Computing, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology & Scientific Computing, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082716179","display_name":"Nisha A. Viswan","orcid":"https://orcid.org/0000-0002-4509-5811","observed_orcids":["https://orcid.org/0000-0002-4509-5811"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nisha A. Viswan","raw_affiliation_strings":["Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082858429","display_name":"Mohammed N. Al\u2010Ahdal","orcid":"https://orcid.org/0000-0002-8707-1594","observed_orcids":["https://orcid.org/0000-0002-8707-1594"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohammed N. Al-Ahdal","raw_affiliation_strings":["Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076853480"],"corresponding_institution_ids":["https://openalex.org/I2800965796","https://openalex.org/I28022161"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":7.4923,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.97945053,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"e80445","last_page":"e80445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hla-dq","display_name":"HLA-DQ","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hla-dp","display_name":"HLA-DP","score":0.9980000257492065},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.949999988079071},{"id":"https://openalex.org/keywords/hbv-clearance","display_name":"HBV clearance","score":0.5960000157356262},{"id":"https://openalex.org/keywords/hepatitis-b-cirrhosis","display_name":"hepatitis B cirrhosis","score":0.671999990940094},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.621999979019165},{"id":"https://openalex.org/keywords/saudi-patients","display_name":"Saudi patients","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hla-allele-frequencies","display_name":"HLA allele frequencies","score":0.6290000081062317},{"id":"https://openalex.org/keywords/hla-dqa1","display_name":"HLA-DQA1","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7487732172012329},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6941400766372681},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6702386736869812},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6012140512466431},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5119487047195435},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5004115104675293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4661363959312439},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.45233818888664246},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.4513855576515198},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4393320083618164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4171471893787384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41479259729385376},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.41036438941955566},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3954312205314636},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3127898871898651},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2017669975757599},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20010989904403687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1952502727508545},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15418192744255066}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012529","descriptor_name":"Saudi Arabia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0080445","doi":"https://doi.org/10.1371/journal.pone.0080445","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0080445","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080445&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2885395","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3898905","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24465366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24465366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3898905","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3898905/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.787.2538","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.787.2538","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ce/db/pone.0080445.PMC3898905.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:57d256a4fe9f4db2815e02b614f1fba2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/57d256a4fe9f4db2815e02b614f1fba2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 1, p e80445 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0080445","doi":"https://doi.org/10.1371/journal.pone.0080445","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0080445","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080445&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321144","display_name":"King Faisal Specialist Hospital and Research Centre","ror":"https://ror.org/05n0wgt02"},{"id":"https://openalex.org/F4320322997","display_name":"King Abdulaziz City for Science and Technology","ror":"https://ror.org/05tdz6m39"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053193232.pdf","grobid_xml":"https://content.openalex.org/works/W2053193232.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W28108870","https://openalex.org/W307346257","https://openalex.org/W1589160957","https://openalex.org/W1969460354","https://openalex.org/W1971697619","https://openalex.org/W1978714340","https://openalex.org/W1981387786","https://openalex.org/W1984941194","https://openalex.org/W1988647224","https://openalex.org/W1988943422","https://openalex.org/W1990426808","https://openalex.org/W1992879006","https://openalex.org/W1997666345","https://openalex.org/W2006256967","https://openalex.org/W2023921578","https://openalex.org/W2051588066","https://openalex.org/W2062755772","https://openalex.org/W2070189629","https://openalex.org/W2074197155","https://openalex.org/W2087564721","https://openalex.org/W2090558763","https://openalex.org/W2093191258","https://openalex.org/W2094087800","https://openalex.org/W2097150100","https://openalex.org/W2101857884","https://openalex.org/W2106293807","https://openalex.org/W2106442980","https://openalex.org/W2134844770","https://openalex.org/W2148568906","https://openalex.org/W2162565737","https://openalex.org/W2395069722","https://openalex.org/W2409543920","https://openalex.org/W4233663157"],"related_works":["https://openalex.org/W2581316264","https://openalex.org/W7154994038","https://openalex.org/W4408276378","https://openalex.org/W2953524950","https://openalex.org/W2417285772","https://openalex.org/W6929883665","https://openalex.org/W2167361877","https://openalex.org/W2620873105","https://openalex.org/W287419010","https://openalex.org/W7222766709"],"abstract_inverted_index":{"Hepatitis":[0],"B":[1],"virus":[2],"(HBV)":[3],"infection":[4,76,175,234,299],"is":[5],"a":[6],"leading":[7],"cause":[8],"of":[9,28,58,66,217,297],"liver":[10],"diseases":[11],"including":[12,34],"cirrhosis":[13],"and":[14,70,114,129,131,138,151,160,169,203,220,253,295],"hepatocellular":[15,110],"carcinoma.":[16],"Human":[17],"leukocyte":[18],"antigens":[19],"(HLAs)":[20],"play":[21],"an":[22],"important":[23],"role":[24,65,73],"in":[25,47,53,74,77,82,87,225,270,275,288,300],"the":[26,64],"regulation":[27],"immune":[29],"response":[30],"against":[31],"infectious":[32],"organisms,":[33],"HBV.":[35],"Recently,":[36],"several":[37],"genome-wide":[38],"association":[39,265],"(GWAS)":[40],"studies":[41],"have":[42],"shown":[43],"that":[44,165,286],"genetic":[45,68],"variations":[46,287],"HLA":[48,67,83,271,289],"genes":[49,84,272,290],"influence":[50],"disease":[51],"progression":[52],"HBV":[54,75,174,298],"infection.":[55],"The":[56,142,162],"aim":[57],"this":[59],"study":[60],"was":[61,266],"to":[62,94,124,135,231,294],"investigate":[63],"polymorphisms":[69,121,269],"their":[71,95],"possible":[72],"Saudi":[78,301],"Arabian":[79,302],"patients.":[80,280,303],"Variations":[81],"were":[85,91,140,144,171,222,273],"screened":[86],"1672":[88],"subjects":[89],"who":[90],"divided":[92],"according":[93],"clinical":[96],"status":[97],"into":[98],"six":[99],"categories":[100],"as":[101],"follows;":[102],"clearance":[103,232,296],"group,":[104],"inactive":[105],"carriers,":[106,108],"active":[107,276],"cirrhosis,":[109],"carcinoma":[111],"(HCC)":[112],"patients":[113,228],"uninfected":[115],"healthy":[116],"controls.":[117],"Three":[118],"single":[119],"nucleotide":[120],"(SNPs)":[122],"belonged":[123,134],"HLA-DQ":[125],"region":[126],"(rs2856718,":[127],"rs7453920":[128,219],"rs9275572)":[130],"two":[132],"SNPs":[133,143],"HLA-DP":[136],"(rs3077":[137],"rs9277535)":[139],"studied.":[141],"genotyped":[145],"by":[146],"PCR-based":[147],"DNA":[148],"sequencing":[149],"(rs2856718)":[150],"allele":[152,215],"specific":[153],"TaqMan":[154],"genotyping":[155],"assays":[156],"(rs3077,":[157],"rs7453920,":[158],"rs9277535":[159,168],"rs9275572).":[161],"results":[163,284],"showed":[164],"rs2856718,":[166,218],"rs3077,":[167],"rs9275572":[170,221],"associated":[172],"with":[173],"(p":[176,235],"=":[177,180,183,186,189,192,195,198,201,205,208,211,236,239,242,245,248,251,255,258,261],"0.0003,":[178],"OR":[179,188,197,207,238,247,257],"1.351,":[181],"CI":[182,191,200,210,241,250,260],"1.147-1.591;":[184],"p":[185,194,204,244,254],"0.041,":[187],"1.20,":[190],"1.007-1.43;":[193],"0.045,":[196],"1.198,":[199],"1.004-1.43":[202],"0.0018,":[206],"0.776,":[209,259],"0.662-0.910,":[212],"respectively).":[213,263],"However,":[214],"frequency":[216],"found":[223,267],"more":[224],"chronically":[226],"infected":[227],"when":[229,268],"compared":[230,274],"group":[233],"0.0001,":[237],"1.462,":[240],"1.204-1.776;":[243],"0.0178,":[246],"1.267,":[249],"1.042-1.540":[252],"0.010,":[256],"0.639-0.942,":[262],"No":[264],"carriers":[277],"versus":[278],"cirrhosis/HCC":[279],"In":[281],"conclusion,":[282],"these":[283],"suggest":[285],"could":[291],"affect":[292],"susceptibility":[293]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}