{"id":"https://openalex.org/W2053045945","doi":"https://doi.org/10.1038/sj.bjc.6602605","title":"Role of novel targeted therapies in the clinic","display_name":"Role of novel targeted therapies in the clinic","publication_year":2005,"publication_date":"2005-05-31","ids":{"openalex":"https://openalex.org/W2053045945","doi":"https://doi.org/10.1038/sj.bjc.6602605","mag":"2053045945","pmid":"https://pubmed.ncbi.nlm.nih.gov/15928655","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2362061"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6602605","doi":"https://doi.org/10.1038/sj.bjc.6602605","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602605","pdf_url":"https://www.nature.com/articles/6602605.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6602605.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R S Herbst","raw_affiliation_strings":["Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 432, Houston, TX 77030-4009, USA. rherbst@mdanderson.org","Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 432, Houston, TX 77030-4009, USA. rherbst@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008593691"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.2754,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.82116675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"92","issue":"S1","first_page":"S21","last_page":"S27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.483599990606308,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.483599990606308,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.15489999949932098,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.08980000019073486,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6448346972465515},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.6029013991355896},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5497175455093384},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5234964489936829},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.435624361038208},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3591940402984619},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1503579318523407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13116160035133362},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10310056805610657},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09495717287063599}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.bjc.6602605","doi":"https://doi.org/10.1038/sj.bjc.6602605","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602605","pdf_url":"https://www.nature.com/articles/6602605.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2362061","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2362061","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:15928655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15928655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.9027","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.9027","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/37/4c/Br_J_Cancer_2005_Jun_31_92(S1)_S21-S27.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6602605","doi":"https://doi.org/10.1038/sj.bjc.6602605","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602605","pdf_url":"https://www.nature.com/articles/6602605.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053045945.pdf","grobid_xml":"https://content.openalex.org/works/W2053045945.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1507842220","https://openalex.org/W1518523258","https://openalex.org/W1603230122","https://openalex.org/W1658047882","https://openalex.org/W1665704747","https://openalex.org/W1769272814","https://openalex.org/W1868766650","https://openalex.org/W1910612303","https://openalex.org/W1991410031","https://openalex.org/W1995745999","https://openalex.org/W2009240587","https://openalex.org/W2043696829","https://openalex.org/W2046507292","https://openalex.org/W2048960456","https://openalex.org/W2076051136","https://openalex.org/W2080533307","https://openalex.org/W2092841476","https://openalex.org/W2096345747","https://openalex.org/W2098287668","https://openalex.org/W2099938880","https://openalex.org/W2100785570","https://openalex.org/W2106964830","https://openalex.org/W2108388128","https://openalex.org/W2109134893","https://openalex.org/W2114159573","https://openalex.org/W2118559000","https://openalex.org/W2120718661","https://openalex.org/W2135123420","https://openalex.org/W2140765540","https://openalex.org/W2140775102","https://openalex.org/W2142564546","https://openalex.org/W2146404049","https://openalex.org/W2148471977","https://openalex.org/W2149923229","https://openalex.org/W2157769714","https://openalex.org/W2161821474","https://openalex.org/W2161965319","https://openalex.org/W2163182836","https://openalex.org/W2163738584","https://openalex.org/W2166573361","https://openalex.org/W2166825418","https://openalex.org/W2170655985","https://openalex.org/W2230520814","https://openalex.org/W2244823046","https://openalex.org/W2246879735","https://openalex.org/W2262509684","https://openalex.org/W2278057905","https://openalex.org/W2332652021","https://openalex.org/W2332800771","https://openalex.org/W2335775292","https://openalex.org/W2405151655","https://openalex.org/W2595387994","https://openalex.org/W2604050871","https://openalex.org/W2604162954","https://openalex.org/W2604494474","https://openalex.org/W2903816102","https://openalex.org/W4235309455"],"related_works":["https://openalex.org/W7097093387","https://openalex.org/W2156447034","https://openalex.org/W2398296163","https://openalex.org/W109541353","https://openalex.org/W2277678393","https://openalex.org/W2045310875","https://openalex.org/W2405244929","https://openalex.org/W2767168338","https://openalex.org/W2048049196","https://openalex.org/W2143165784"],"abstract_inverted_index":{"The":[0,17],"number":[1,60],"and":[2,36,80,112],"variety":[3],"of":[4,19,42,61,77],"novel,":[5],"molecular-targeted":[6,78],"agents":[7],"offers":[8],"realistic":[9],"hope":[10],"for":[11,100,123],"significant":[12],"advances":[13],"in":[14,67],"cancer":[15],"treatment.":[16],"potential":[18],"these":[20],"new":[21],"treatment":[22,62],"approaches":[23],"is":[24,29,45,52],"unquestionable,":[25],"but":[26,50],"the":[27,68,97,121],"reality":[28],"something":[30],"that":[31,54],"only":[32],"thorough":[33],"clinical":[34],"evaluation":[35],"experience":[37,41],"can":[38],"reveal.":[39],"Clinical":[40],"targeted":[43],"therapies":[44,79],"at":[46],"an":[47,58],"early":[48],"stage":[49],"it":[51],"likely":[53],"we":[55,115],"will":[56],"have":[57],"increasing":[59],"options":[63],"available":[64],"to":[65],"us":[66],"near":[69],"future.":[70],"This":[71],"manuscript":[72],"explores":[73],"our":[74],"current":[75],"understanding":[76],"considers:":[81],"What":[82],"approach":[83],"should":[84,92,103,114],"be":[85,94,105,116],"used?":[86,106],"(single":[87],"vs":[88],"multitarget":[89],"agents);":[90],"When":[91],"they":[93,104],"administered?":[95],"(identifying":[96],"optimal":[98],"point":[99],"intervention);":[101],"How":[102],"(monotherapy":[107],"or":[108],"combination":[109],"therapy":[110],"regimens);":[111],"Who":[113],"giving":[117],"them":[118],"to?":[119],"(acknowledging":[120],"need":[122],"patient":[124],"selection).":[125]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
