{"id":"https://openalex.org/W2053041620","doi":"https://doi.org/10.1097/spc.0b013e3282f5273f","title":"Tyrosine kinase inhibitors and gut toxicity: a new era in supportive care","display_name":"Tyrosine kinase inhibitors and gut toxicity: a new era in supportive care","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2053041620","doi":"https://doi.org/10.1097/spc.0b013e3282f5273f","mag":"2053041620","pmid":"https://pubmed.ncbi.nlm.nih.gov/18685389"},"language":"en","primary_location":{"id":"doi:10.1097/spc.0b013e3282f5273f","doi":"https://doi.org/10.1097/spc.0b013e3282f5273f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/spc.0b013e3282f5273f","pdf_url":null,"source":{"id":"https://openalex.org/S148489009","display_name":"Current Opinion in Supportive and Palliative Care","issn_l":"1751-4258","issn":["1751-4258","1751-4266"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Supportive & Palliative Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055550975","display_name":"Dorothy M. K. Keefe","orcid":"https://orcid.org/0000-0001-9377-431X","observed_orcids":["https://orcid.org/0000-0001-9377-431X"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Dorothy Keefe","raw_affiliation_strings":["Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia. dorothy.keefe@health.sa.gov.au","Clinical Director, RAH Cancer Centre, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia Tel: +618 8222 5577","Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia","e-mail: [email\u00a0protected]","fax: +618 8222 4358","to Dorothy Keefe, MD, FRACP. TCCSA Professor of Cancer Medicine, University of Adelaide"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia. dorothy.keefe@health.sa.gov.au","institution_ids":["https://openalex.org/I1320133117"]},{"raw_affiliation_string":"Clinical Director, RAH Cancer Centre, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia Tel: +618 8222 5577","institution_ids":["https://openalex.org/I1320133117"]},{"raw_affiliation_string":"Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I1320133117"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +618 8222 4358","institution_ids":[]},{"raw_affiliation_string":"to Dorothy Keefe, MD, FRACP. TCCSA Professor of Cancer Medicine, University of Adelaide","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005448318","display_name":"Lowell Brian Anthony","orcid":"https://orcid.org/0000-0001-7348-7874","observed_orcids":["https://orcid.org/0000-0001-7348-7874"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lowell Anthony","raw_affiliation_strings":["Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I1320133117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055550975"],"corresponding_institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I5681781"],"apc_list":null,"apc_paid":null,"fwci":0.6904,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.72271127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"1","first_page":"19","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.295199990272522,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.295199990272522,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.23970000445842743,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":1.0},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/supportive-care","display_name":"supportive care","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.5370000004768372},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8810810446739197},{"id":"https://openalex.org/C2776638177","wikidata":"https://www.wikidata.org/wiki/Q838625","display_name":"Terrace (agriculture)","level":2,"score":0.5245128870010376},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.4168504476547241},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.09199488162994385},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/spc.0b013e3282f5273f","doi":"https://doi.org/10.1097/spc.0b013e3282f5273f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/spc.0b013e3282f5273f","pdf_url":null,"source":{"id":"https://openalex.org/S148489009","display_name":"Current Opinion in Supportive and Palliative Care","issn_l":"1751-4258","issn":["1751-4258","1751-4266"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Supportive & Palliative Care","raw_type":"journal-article"},{"id":"pmid:18685389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18685389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in supportive and palliative care","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1978454448","https://openalex.org/W2011513069","https://openalex.org/W2056516171","https://openalex.org/W2058360220","https://openalex.org/W2083593111","https://openalex.org/W2123773954","https://openalex.org/W2137347078","https://openalex.org/W2141159248","https://openalex.org/W2171215288"],"related_works":["https://openalex.org/W7037875870","https://openalex.org/W3083714720","https://openalex.org/W7124397606","https://openalex.org/W2898527165","https://openalex.org/W2316471461","https://openalex.org/W4392511000","https://openalex.org/W3205099632","https://openalex.org/W2903958525","https://openalex.org/W2330769784","https://openalex.org/W2594408574"],"abstract_inverted_index":{"Royal":[0,28],"Adelaide":[1,29],"Hospital,":[2,30],"North":[3,31],"Terrace,":[4,32],"Adelaide,":[5,33],"South":[6],"Australia,":[7],"Australia":[8,36],"Correspondence":[9],"to":[10],"Dorothy":[11],"Keefe,":[12],"MD,":[13],"FRACP.":[14],"TCCSA":[15],"Professor":[16],"of":[17,21],"Cancer":[18,26],"Medicine,":[19],"University":[20],"Adelaide;":[22],"Clinical":[23],"Director,":[24],"RAH":[25],"Centre,":[27],"SA":[34],"5000,":[35],"Tel:":[37],"+618":[38,42],"8222":[39,43],"5577;":[40],"fax:":[41],"4358;":[44],"e-mail:":[45],"[email":[46],"protected]":[47]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}