{"id":"https://openalex.org/W2052998740","doi":"https://doi.org/10.4172/2155-9570.1000287","title":"Thioredoxin Interacting Protein (TXNIP) and Pathogenesis of Diabetic Retinopathy","display_name":"Thioredoxin Interacting Protein (TXNIP) and Pathogenesis of Diabetic Retinopathy","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2052998740","doi":"https://doi.org/10.4172/2155-9570.1000287","mag":"2052998740","pmid":"https://pubmed.ncbi.nlm.nih.gov/24353900","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3864179"},"language":"en","primary_location":{"id":"doi:10.4172/2155-9570.1000287","doi":"https://doi.org/10.4172/2155-9570.1000287","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2155-9570.1000287","pdf_url":null,"source":{"id":"https://openalex.org/S2764388994","display_name":"Journal of Clinical & Experimental Ophthalmology","issn_l":"2155-9570","issn":["2155-9570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical & Experimental Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3864179","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078632960","display_name":"Lalit Pukhrambam Singh","orcid":"https://orcid.org/0000-0002-4600-9137","observed_orcids":["https://orcid.org/0000-0002-4600-9137","https://orcid.org/0000-0002-6221-8174"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lalit P Singh","raw_affiliation_strings":["Departments of Anatomy and Cell Biology and Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078632960"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":null,"apc_paid":null,"fwci":5.215,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.95377121,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"04","issue":"04","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.9789999723434448},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.828000009059906},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.9490000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7570000290870667},{"id":"https://openalex.org/keywords/thioredoxin","display_name":"thioredoxin","score":0.7839999794960022},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8700000047683716},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pericyte-loss","display_name":"pericyte loss","score":0.6650000214576721},{"id":"https://openalex.org/keywords/blood-retinal-barrier","display_name":"blood-retinal barrier","score":0.6320000290870667},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.7440000176429749},{"id":"https://openalex.org/keywords/hexosamine-biosynthesis-pathway","display_name":"hexosamine biosynthetic pathway","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C2779076967","wikidata":"https://www.wikidata.org/wiki/Q21122281","display_name":"TXNIP","level":4,"score":0.9539881944656372},{"id":"https://openalex.org/C136502266","wikidata":"https://www.wikidata.org/wiki/Q7226667","display_name":"Polyol pathway","level":4,"score":0.645864725112915},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.6332474946975708},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5855145454406738},{"id":"https://openalex.org/C2780427682","wikidata":"https://www.wikidata.org/wiki/Q500446","display_name":"Pericyte","level":4,"score":0.5281579494476318},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4851458966732025},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.48013684153556824},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.43546727299690247},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4114450216293335},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.40275752544403076},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.3832568824291229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3777350187301636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.362181693315506},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.35685431957244873},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.32750970125198364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2874419093132019},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2775391638278961},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.2440977394580841},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21526244282722473},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.15226253867149353},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4172/2155-9570.1000287","doi":"https://doi.org/10.4172/2155-9570.1000287","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2155-9570.1000287","pdf_url":null,"source":{"id":"https://openalex.org/S2764388994","display_name":"Journal of Clinical & Experimental Ophthalmology","issn_l":"2155-9570","issn":["2155-9570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical & Experimental Ophthalmology","raw_type":"journal-article"},{"id":"pmid:24353900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24353900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical & experimental ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2848414","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3864179","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3864179","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3864179","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Clin Exp Ophthalmol","raw_type":"Text"},{"id":"mag:2181379517","doi":null,"is_oa":false,"landing_page_url":"https://omicsonline.org/thioredoxin-interacting-protein-txnip-and-pathogenesis-of-diabetic-retinopathy-2155-9570.1000287.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2848414","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3864179","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000863115","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY004068","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320325760","display_name":"Oogfonds","ror":"https://ror.org/00x6ysg61"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":181,"referenced_works":["https://openalex.org/W32331224","https://openalex.org/W92471217","https://openalex.org/W97557810","https://openalex.org/W99772692","https://openalex.org/W143374494","https://openalex.org/W1549203021","https://openalex.org/W1573057296","https://openalex.org/W1587498818","https://openalex.org/W1672954108","https://openalex.org/W1755192176","https://openalex.org/W1895408795","https://openalex.org/W1895565798","https://openalex.org/W1964267325","https://openalex.org/W1964407258","https://openalex.org/W1965259644","https://openalex.org/W1966078609","https://openalex.org/W1966977448","https://openalex.org/W1967429010","https://openalex.org/W1969216908","https://openalex.org/W1973834502","https://openalex.org/W1975067781","https://openalex.org/W1975707328","https://openalex.org/W1975915247","https://openalex.org/W1976268751","https://openalex.org/W1978907420","https://openalex.org/W1979268981","https://openalex.org/W1981122508","https://openalex.org/W1985538633","https://openalex.org/W1989051171","https://openalex.org/W1989287785","https://openalex.org/W1991493135","https://openalex.org/W1991934654","https://openalex.org/W1993541144","https://openalex.org/W1993936453","https://openalex.org/W1997309935","https://openalex.org/W1999329529","https://openalex.org/W2001614846","https://openalex.org/W2001786332","https://openalex.org/W2001802780","https://openalex.org/W2002022907","https://openalex.org/W2004170579","https://openalex.org/W2004429089","https://openalex.org/W2006477603","https://openalex.org/W2006869556","https://openalex.org/W2007114641","https://openalex.org/W2010346432","https://openalex.org/W2011297849","https://openalex.org/W2011355596","https://openalex.org/W2012296166","https://openalex.org/W2012314430","https://openalex.org/W2012796686","https://openalex.org/W2016345983","https://openalex.org/W2017784759","https://openalex.org/W2018607502","https://openalex.org/W2019253922","https://openalex.org/W2019455536","https://openalex.org/W2020170893","https://openalex.org/W2023525778","https://openalex.org/W2024359249","https://openalex.org/W2024564404","https://openalex.org/W2024619700","https://openalex.org/W2025569306","https://openalex.org/W2027936403","https://openalex.org/W2029881431","https://openalex.org/W2030115491","https://openalex.org/W2033236322","https://openalex.org/W2033457930","https://openalex.org/W2034722331","https://openalex.org/W2034946303","https://openalex.org/W2035010201","https://openalex.org/W2035236274","https://openalex.org/W2035839706","https://openalex.org/W2036872904","https://openalex.org/W2036906474","https://openalex.org/W2039666046","https://openalex.org/W2043096852","https://openalex.org/W2043463860","https://openalex.org/W2044781509","https://openalex.org/W2045561438","https://openalex.org/W2045679421","https://openalex.org/W2047003538","https://openalex.org/W2047446648","https://openalex.org/W2047802468","https://openalex.org/W2050908549","https://openalex.org/W2051241024","https://openalex.org/W2052352342","https://openalex.org/W2053736563","https://openalex.org/W2056077438","https://openalex.org/W2056517196","https://openalex.org/W2056752509","https://openalex.org/W2058722090","https://openalex.org/W2059541234","https://openalex.org/W2059563381","https://openalex.org/W2059881088","https://openalex.org/W2060157902","https://openalex.org/W2060539596","https://openalex.org/W2060555951","https://openalex.org/W2060653943","https://openalex.org/W2061741332","https://openalex.org/W2064639374","https://openalex.org/W2064718087","https://openalex.org/W2065309335","https://openalex.org/W2065413522","https://openalex.org/W2066601673","https://openalex.org/W2070937642","https://openalex.org/W2071466648","https://openalex.org/W2072576441","https://openalex.org/W2073287644","https://openalex.org/W2075338426","https://openalex.org/W2075404840","https://openalex.org/W2075753953","https://openalex.org/W2080340309","https://openalex.org/W2080816502","https://openalex.org/W2081985889","https://openalex.org/W2082263082","https://openalex.org/W2083299002","https://openalex.org/W2086256951","https://openalex.org/W2086557228","https://openalex.org/W2086919198","https://openalex.org/W2087576630","https://openalex.org/W2088735475","https://openalex.org/W2089728480","https://openalex.org/W2089927477","https://openalex.org/W2090543186","https://openalex.org/W2090839009","https://openalex.org/W2091152653","https://openalex.org/W2091340781","https://openalex.org/W2091661907","https://openalex.org/W2091676715","https://openalex.org/W2092457562","https://openalex.org/W2093265233","https://openalex.org/W2098563995","https://openalex.org/W2098859948","https://openalex.org/W2098940128","https://openalex.org/W2099258317","https://openalex.org/W2100465511","https://openalex.org/W2100935477","https://openalex.org/W2103624639","https://openalex.org/W2106172512","https://openalex.org/W2106749977","https://openalex.org/W2107325549","https://openalex.org/W2107347124","https://openalex.org/W2107766440","https://openalex.org/W2111566945","https://openalex.org/W2111586778","https://openalex.org/W2112777760","https://openalex.org/W2113286070","https://openalex.org/W2113997795","https://openalex.org/W2117444367","https://openalex.org/W2117760639","https://openalex.org/W2119716898","https://openalex.org/W2122393245","https://openalex.org/W2124411435","https://openalex.org/W2124600404","https://openalex.org/W2125281412","https://openalex.org/W2125557982","https://openalex.org/W2129929756","https://openalex.org/W2132403739","https://openalex.org/W2132812582","https://openalex.org/W2133446948","https://openalex.org/W2136462501","https://openalex.org/W2137065941","https://openalex.org/W2147810846","https://openalex.org/W2148300997","https://openalex.org/W2149650645","https://openalex.org/W2149705831","https://openalex.org/W2151367512","https://openalex.org/W2153008086","https://openalex.org/W2154104081","https://openalex.org/W2157274841","https://openalex.org/W2160623613","https://openalex.org/W2160899250","https://openalex.org/W2163584103","https://openalex.org/W2169529937","https://openalex.org/W2170492101","https://openalex.org/W2171213306","https://openalex.org/W2333591128","https://openalex.org/W2795423012","https://openalex.org/W4240304626","https://openalex.org/W4253434130","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2181379517","https://openalex.org/W2065413522","https://openalex.org/W4290744424","https://openalex.org/W2001614846","https://openalex.org/W7095170674","https://openalex.org/W1993936453","https://openalex.org/W2613100647","https://openalex.org/W2941118629","https://openalex.org/W3120224585","https://openalex.org/W2345944563"],"abstract_inverted_index":{"Chronic":[0],"hyperglycemia":[1],"(HG)-associated":[2],"reactive":[3],"oxygen/nitrogen":[4],"species":[5],"(ROS/RNS)":[6],"stress":[7],"and":[8,48,65,79,84,98,115,129,145,162,178,187,231,249,262],"low":[9],"grade":[10],"inflammation":[11,128],"are":[12,52,73,171,215],"considered":[13,138],"to":[14,92,108,218],"play":[15],"critical":[16,256],"roles":[17],"in":[18,55,96,101,104,133,176,192,202,210,223],"the":[19,30,228,251],"development":[20],"of":[21,67,121,142,245,264],"diabetic":[22],"retinopathy":[23],"(DR).":[24],"Excess":[25],"glucose":[26],"metabolic":[27,229],"flux":[28],"through":[29],"aldose":[31],"reductase/polyol":[32],"pathway,":[33],"advanced":[34],"glycation":[35],"end":[36],"product":[37],"(AGE)":[38],"formation,":[39],"elevated":[40],"hexosamine":[41],"biosynthesis":[42],"pathway":[43],"(HBP),":[44],"diacyl":[45],"glycerol/PKC":[46],"activation,":[47,183],"mitochondrial":[49,68,126],"ROS":[50],"generation":[51],"all":[53],"implicated":[54],"DR.":[56,134,193,203,224,265],"In":[57,194],"addition,":[58,195],"endoplasmic":[59],"reticulum":[60],"stress/unfolded":[61],"protein":[62,88],"response":[63],"(er-UPR)":[64],"deregulation":[66],"quality":[69],"control":[70],"by":[71,99,149,174,208,240],"autophagy/mitophagy":[72],"observed":[74],"causing":[75],"cellular":[76],"bioenergetic":[77],"deficiency":[78],"injury.":[80],"Recently,":[81],"a":[82,219],"pro-oxidant":[83],"pro-apoptotic":[85],"thioredoxin":[86,109],"interacting":[87],"(TXNIP)":[89],"was":[90,137],"shown":[91],"be":[93,237,255],"highly":[94],"upregulated":[95],"DR":[97,136],"HG":[100,175,209],"retinal":[102,157,196],"cells":[103,235,248],"culture.":[105],"TXNIP":[106,122,205,241,246],"binds":[107],"(Trx)":[110],"inhibiting":[111],"its":[112,213],"oxidant":[113],"scavenging":[114],"thiolreducing":[116],"capacity.":[117],"Hence,":[118],"prolonged":[119],"overexpression":[120],"causes":[123],"ROS/RNS":[124],"stress,":[125],"dysfunction,":[127],"premature":[130],"cell":[131,221,260],"death":[132,261],"Initially,":[135],"as":[139],"microvascular":[140],"complications":[141],"endothelial":[143],"dysfunction":[144],"pericyte":[146,154],"loss":[147],"characterized":[148],"capillary":[150,161],"basement":[151],"membrane":[152],"thickening,":[153],"ghost,":[155],"blood":[156],"barrier":[158],"leakage,":[159],"acellular":[160],"neovascularization.":[163],"However,":[164,225],"it":[165],"is":[166,206],"currently":[167],"acknowledged":[168],"that":[169,179],"neuro-glia":[170],"also":[172],"affected":[173,238],"diabetes":[177],"neuronal":[180],"injury,":[181],"glial":[182],"innate":[184],"immunity/sterile":[185],"inflammation,":[186],"ganglion":[188],"apoptosis":[189],"occur":[190],"early":[191],"pigment":[197],"epithelium":[198],"(RPE)":[199],"becomes":[200],"dysfunctional":[201],"Since":[204],"induced":[207],"most":[211],"cells,":[212],"effects":[214],"not":[216],"restricted":[217],"particular":[220],"type":[222],"depending":[226],"on":[227],"activity":[230],"anti-oxidant":[232],"capacity,":[233],"some":[234],"may":[236],"earlier":[239],"than":[242],"others.":[243],"Identification":[244],"sensitive":[247],"elucidating":[250],"underlying":[252],"mechanism(s)":[253],"will":[254],"for":[257],"preventing":[258],"pre-mature":[259],"progression":[263]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}