{"id":"https://openalex.org/W2052986338","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","title":"Multiple myeloma in the geriatric patient","display_name":"Multiple myeloma in the geriatric patient","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W2052986338","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","mag":"2052986338","pmid":"https://pubmed.ncbi.nlm.nih.gov/2386924"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900901%2966%3A5%3C965%3A%3AAID-CNCR2820660526%3E3.0.CO%3B2-M","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900901%2966%3A5%3C965%3A%3AAID-CNCR2820660526%3E3.0.CO%3B2-M","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058720539","display_name":"Paul Froom","orcid":"https://orcid.org/0000-0001-5126-8590","observed_orcids":["https://orcid.org/0000-0001-5126-8590"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul Froom","raw_affiliation_strings":["Institute of Haematology, Lady Davis Carmel Hospital, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Haematology, Lady Davis Carmel Hospital, Haifa, Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061031141","display_name":"Miriam Quitt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miriam Quitt","raw_affiliation_strings":["Institute of Haematology, Lady Davis Carmel Hospital, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Haematology, Lady Davis Carmel Hospital, Haifa, Israel","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108349893","display_name":"E Aghai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther Aghai","raw_affiliation_strings":["Institute of Haematology, Lady Davis Carmel Hospital, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Haematology, Lady Davis Carmel Hospital, Haifa, Israel","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058720539"],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.9956,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75553644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"66","issue":"5","first_page":"965","last_page":"967"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.597000002861023},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8349999785423279},{"id":"https://openalex.org/keywords/age-at-presentation","display_name":"age at presentation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/hemoglobin-levels","display_name":"hemoglobin levels","score":0.8140000104904175},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bone-lesions","display_name":"bone lesions","score":0.6050000190734863},{"id":"https://openalex.org/keywords/bone-marrow-plasma-cells","display_name":"bone marrow plasma cells","score":0.6909999847412109},{"id":"https://openalex.org/keywords/comprehensive-geriatric-assessment","display_name":"comprehensive geriatric assessment","score":0.7739999890327454},{"id":"https://openalex.org/keywords/supportive-therapy","display_name":"supportive therapy","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9358044862747192},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.8054379820823669},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.6432920694351196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.573269248008728},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5526849627494812},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5112166404724121}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900901%2966%3A5%3C965%3A%3AAID-CNCR2820660526%3E3.0.CO%3B2-M","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:2386924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2386924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900901)66:5<965::aid-cncr2820660526>3.0.co;2-m","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900901%2966%3A5%3C965%3A%3AAID-CNCR2820660526%3E3.0.CO%3B2-M","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052986338.pdf"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1574826837","https://openalex.org/W1966912003","https://openalex.org/W1983112707","https://openalex.org/W1991890714","https://openalex.org/W2006318999","https://openalex.org/W2029590115","https://openalex.org/W2047499850","https://openalex.org/W2075458904","https://openalex.org/W2081455516","https://openalex.org/W2098355416","https://openalex.org/W2264494566","https://openalex.org/W2318206769","https://openalex.org/W2440333230"],"related_works":["https://openalex.org/W2049939736","https://openalex.org/W2012536088","https://openalex.org/W1993368580","https://openalex.org/W2365428976","https://openalex.org/W1993500080","https://openalex.org/W2565995595","https://openalex.org/W133911600","https://openalex.org/W4386846476","https://openalex.org/W2140446648","https://openalex.org/W2565352973"],"abstract_inverted_index":{"Consecutive":[0],"patients":[1,14,24,33],"with":[2,163,175],"multiple":[3,176],"myeloma":[4],"were":[5,20,69],"studied.":[6],"The":[7],"clinical":[8],"characteristics":[9],"and":[10,67,78,122,125,148,159],"survival":[11,73],"of":[12,29,51,72,86,99,104,116],"17":[13],"aged":[15],"75":[16,27,36,54],"years":[17,28,55],"or":[18],"more":[19,105,155],"compared":[21,46],"to":[22,47,133,168],"42":[23],"younger":[25],"than":[26,35,43,59,76,81,94,106],"age.":[30],"Of":[31],"the":[32,87,97,102,111,114,123,134,139,172],"older":[34],"years,":[37],"14/17":[38],"(82%)":[39],"died":[40],"in":[41,110],"less":[42,58,75,80,93],"12":[44],"months":[45],"only":[48],"11/42":[49],"(26%)":[50],"those":[52],"under":[53],"old":[56],"(P":[57,74],"0.001).":[60],"Multivariate":[61],"analysis":[62],"showed":[63],"that":[64,138,141],"both":[65],"age":[66,149],"hemoglobin":[68,146],"significant":[70],"predictors":[71],"0.012":[77],"P":[79,92],"0.002,":[82],"respectively)":[83],"explaining":[84],"34.6%":[85],"variance":[88],"(r":[89],"=":[90],"0.588,":[91],"0.000),":[95],"whereas":[96],"extent":[98],"bone":[100,112],"lesions,":[101],"presence":[103],"50%":[107],"plasma":[108],"cells":[109],"marrow,":[113],"amount":[115],"serum":[117],"monoclonal":[118],"protein,":[119],"functional":[120],"class,":[121],"Salmon":[124],"Durie":[126],"staging":[127],"system":[128],"did":[129],"not":[130],"significantly":[131],"add":[132],"analysis.":[135],"We":[136],"conclude":[137],"factors":[140],"best":[142],"predict":[143],"prognosis":[144],"are":[145],"levels":[147],"at":[150],"presentation.":[151],"Different":[152],"approaches":[153],"including":[154],"appropriate":[156],"chemotherapeutic":[157],"regimes":[158],"comprehensive":[160],"geriatric":[161,173],"assessment":[162],"improved":[164],"supportive":[165],"treatment":[166],"need":[167],"be":[169],"developed":[170],"for":[171],"patient":[174],"myeloma.":[177]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}