{"id":"https://openalex.org/W2052974495","doi":"https://doi.org/10.1046/j.1471-4159.2000.0752546.x","title":"Sensitization of Neuronal Cells to Oxidative Stress with Mutated Human \u03b1\u2010Synuclein","display_name":"Sensitization of Neuronal Cells to Oxidative Stress with Mutated Human \u03b1\u2010Synuclein","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2052974495","doi":"https://doi.org/10.1046/j.1471-4159.2000.0752546.x","mag":"2052974495","pmid":"https://pubmed.ncbi.nlm.nih.gov/11080208"},"language":"en","primary_location":{"id":"doi:10.1046/j.1471-4159.2000.0752546.x","doi":"https://doi.org/10.1046/j.1471-4159.2000.0752546.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.2000.0752546.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106183347","display_name":"Li\u2010wen Ko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li\u2010wen Ko","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida 32224, USA","Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida 32224, USA","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033791099","display_name":"Nitin D. Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin D. Mehta","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050824228","display_name":"Matthew James Farrer","orcid":"https://orcid.org/0000-0003-1159-5321","observed_orcids":["https://orcid.org/0000-0003-1159-5321"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Farrer","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022864711","display_name":"Colin Easson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin Easson","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052470056","display_name":"Jennifer Hussey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Hussey","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111940095","display_name":"S. -H. Yen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Yen","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111947017","display_name":"Shu-Hui C. Yen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu\u2010Hui C. Yen","raw_affiliation_strings":["Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Mayo Clinic, Jacksonville, Florida, U.S.A","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":7.5547,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.97840462,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"75","issue":"6","first_page":"2546","last_page":"2554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9629999995231628},{"id":"https://openalex.org/keywords/alpha-synuclein-mutations","display_name":"alpha-synuclein mutations","score":0.902999997138977},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9049999713897705},{"id":"https://openalex.org/keywords/menadione","display_name":"menadione","score":0.8190000057220459},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8560000061988831},{"id":"https://openalex.org/keywords/neuronal-sensitivity","display_name":"neuronal sensitivity","score":0.5550000071525574},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.7549999952316284},{"id":"https://openalex.org/keywords/a30p-mutation","display_name":"A30P mutation","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7436206340789795},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.559727668762207},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5361466407775879},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.511501669883728},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4932040572166443},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.48052915930747986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4781138300895691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4713132977485657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3889049291610718},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34815239906311035},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.3361927270889282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25805002450942993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2041744887828827},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16632163524627686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16444724798202515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1553555727005005},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14394930005073547}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051843","descriptor_name":"Synucleins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1471-4159.2000.0752546.x","doi":"https://doi.org/10.1046/j.1471-4159.2000.0752546.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.2000.0752546.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:11080208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11080208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1358926","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1358926/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF NEUROCHEMISTRY , 75 (6) pp. 2546-2554. (2000)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3006857196","display_name":"AGING AND ALZHEIMER DEMENTIA--ROLE OF FIBROUS PROTEINS","funder_award_id":"R01AG004145","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W74300758","https://openalex.org/W1489341550","https://openalex.org/W1527671059","https://openalex.org/W1530609782","https://openalex.org/W1572679174","https://openalex.org/W1595656597","https://openalex.org/W1708468382","https://openalex.org/W1900066504","https://openalex.org/W1972665983","https://openalex.org/W1975349637","https://openalex.org/W1986042913","https://openalex.org/W1986625112","https://openalex.org/W1991130856","https://openalex.org/W1998134951","https://openalex.org/W1999159261","https://openalex.org/W2001407922","https://openalex.org/W2004315433","https://openalex.org/W2008023026","https://openalex.org/W2013313629","https://openalex.org/W2016473759","https://openalex.org/W2026961747","https://openalex.org/W2030748454","https://openalex.org/W2034210468","https://openalex.org/W2040706104","https://openalex.org/W2042143348","https://openalex.org/W2049104084","https://openalex.org/W2049819787","https://openalex.org/W2050101404","https://openalex.org/W2050786534","https://openalex.org/W2059261643","https://openalex.org/W2061052410","https://openalex.org/W2061799837","https://openalex.org/W2064444660","https://openalex.org/W2065949544","https://openalex.org/W2070194097","https://openalex.org/W2071087722","https://openalex.org/W2071243806","https://openalex.org/W2073135755","https://openalex.org/W2074710446","https://openalex.org/W2075927534","https://openalex.org/W2082214510","https://openalex.org/W2086857730","https://openalex.org/W2091265794","https://openalex.org/W2094823374","https://openalex.org/W2107434243","https://openalex.org/W2110336102","https://openalex.org/W2116597539","https://openalex.org/W2130323165","https://openalex.org/W2133068803","https://openalex.org/W2133155833","https://openalex.org/W2135725455","https://openalex.org/W2150656456"],"related_works":["https://openalex.org/W2049104084","https://openalex.org/W2069632588","https://openalex.org/W4240110553","https://openalex.org/W1557235501","https://openalex.org/W2461216419","https://openalex.org/W1981701640","https://openalex.org/W967908867","https://openalex.org/W2964723648","https://openalex.org/W2056963615","https://openalex.org/W4413317760"],"abstract_inverted_index":{"Linkage":[0],"of":[1,12,18,38,55,61,91],"alpha-synuclein":[2],"(alpha-SN)":[3],"mutations":[4],"to":[5,67,112],"familial":[6,25],"Parkinson's":[7],"disease":[8],"(PD)":[9],"and":[10,24,85],"presence":[11],"alpha-SN":[13,28,42,63],"as":[14],"a":[15],"major":[16],"constituent":[17],"Lewy":[19],"body":[20],"in":[21,30,77,81],"both":[22],"sporadic":[23],"PD":[26,31],"implicate":[27],"abnormality":[29],"pathogenesis.":[32],"Here":[33],"we":[34],"demonstrate":[35],"that":[36,98],"overexpression":[37],"wild-type":[39],"or":[40,52],"mutant":[41,62],"does":[43],"not":[44],"cause":[45],"any":[46],"deleterious":[47],"effect":[48],"on":[49],"the":[50],"growth":[51],"continued":[53],"propagation":[54],"transfected":[56],"human":[57],"cells,":[58],"but":[59],"overproduction":[60],"heightens":[64],"their":[65,82],"sensitivity":[66],"menadione-induced":[68],"oxidative":[69,113],"injury.":[70],"Such":[71],"enhanced":[72],"vulnerability":[73],"is":[74,86],"more":[75],"pronounced":[76],"neuronal":[78,110],"transfectants":[79],"than":[80],"nonneuronal":[83],"counterparts":[84],"associated":[87],"with":[88,102],"increased":[89],"production":[90],"reactive":[92],"oxygen":[93],"species.":[94],"The":[95],"data":[96],"suggest":[97],"mutated":[99],"alpha-SN,":[100],"especially":[101],"an":[103],"alanine-to-proline":[104],"substitution":[105],"at":[106],"residue":[107],"30,":[108],"sensitizes":[109],"cells":[111],"damage.":[114]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
