{"id":"https://openalex.org/W2052961933","doi":"https://doi.org/10.1172/jci1594","title":"Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.","display_name":"Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.","publication_year":1998,"publication_date":"1998-04-15","ids":{"openalex":"https://openalex.org/W2052961933","doi":"https://doi.org/10.1172/jci1594","mag":"2052961933","pmid":"https://pubmed.ncbi.nlm.nih.gov/9541510","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/508761"},"language":"en","primary_location":{"id":"doi:10.1172/jci1594","doi":"https://doi.org/10.1172/jci1594","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci1594","pdf_url":"http://www.jci.org/articles/view/1594/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/1594/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Abe","raw_affiliation_strings":["Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan","Second Dept. of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Second Dept. of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111186665","display_name":"N Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Yamada","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038613022","display_name":"Katsuo Kamata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204291657","display_name":"Hosei University","ror":"https://ror.org/00bx6dj65","country_code":"JP","type":"education","lineage":["https://openalex.org/I204291657"]},{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kamata","raw_affiliation_strings":["Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan","institution_ids":["https://openalex.org/I204291657","https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109160576","display_name":"Tomoyuki Kuwaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Kuwaki","raw_affiliation_strings":["Second Department of Physiology, School of Medicine, Chiba University, Chiba, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Physiology, School of Medicine, Chiba University, Chiba, Japan;","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057996211","display_name":"Masako Shimada","orcid":"https://orcid.org/0000-0002-8384-780X","observed_orcids":["https://orcid.org/0000-0002-8384-780X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Shimada","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029202845","display_name":"Jun-ichi Osuga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Osuga","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029937054","display_name":"Futoshi Shionoiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F Shionoiri","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082465084","display_name":"Naoya Yahagi","orcid":"https://orcid.org/0000-0002-1823-1865","observed_orcids":["https://orcid.org/0000-0002-1823-1865"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Yahagi","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112639169","display_name":"Takuya Kadowaki","orcid":"https://orcid.org/0009-0002-0847-1205","observed_orcids":["https://orcid.org/0009-0002-0847-1205"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Kadowaki","raw_affiliation_strings":["Third Depart- ment of Internal Medicine , University of Tokyo , 7-3-1 Hongo , Bun- kyo-ku , Tokyo 113 , Japan","Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Depart- ment of Internal Medicine , University of Tokyo , 7-3-1 Hongo , Bun- kyo-ku , Tokyo 113 , Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111600270","display_name":"Hiroyuki Tamemoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Tamemoto","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112176058","display_name":"S Ishibashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Ishibashi","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053851057","display_name":"Y Yazaki","orcid":"https://orcid.org/0000-0003-4976-1022","observed_orcids":["https://orcid.org/0000-0003-4976-1022"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Yazaki","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016954071","display_name":"Masatoshi Makuuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Makuuchi","raw_affiliation_strings":["Second Department of Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":9.8013,"has_fulltext":true,"cited_by_count":229,"citation_normalized_percentile":{"value":0.98906087,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"101","issue":"8","first_page":"1784","last_page":"1788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/coronary-risk-factors","display_name":"coronary risk factors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/plasma-triglycerides","display_name":"plasma triglycerides","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8896942734718323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8657029867172241},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8255025148391724},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.7469931840896606},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5536815524101257},{"id":"https://openalex.org/C201624660","wikidata":"https://www.wikidata.org/wiki/Q15334084","display_name":"IRS1","level":5,"score":0.531895637512207},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5158538222312927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5092419385910034},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.502680778503418},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.47133398056030273},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.43442779779434204},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.4236999750137329},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4106111228466034},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.24568423628807068},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.18453189730644226}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1172/jci1594","doi":"https://doi.org/10.1172/jci1594","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci1594","pdf_url":"http://www.jci.org/articles/view/1594/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:9541510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9541510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00843:0001608910","doi":null,"is_oa":true,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/records/17609","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of clinical investigation","raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:508761","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC508761/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.9550","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.9550","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://lipid.umin.ne.jp/pdf/JCIabe.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.516.6642","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.516.6642","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.tulips.tsukuba.ac.jp/dspace/bitstream/2241/102296/1/JCI_101-8.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.521.8260","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.521.8260","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.tulips.tsukuba.ac.jp/dspace/bitstream/2241/102296/1/JCI_101-8.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.524.5731","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.524.5731","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://polaris.hoshi.ac.jp/openresearch/3.pdf","raw_type":"text"},{"id":"pmh:oai:tsukuba.repo.nii.ac.jp:00017609","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2241/102296","pdf_url":null,"source":{"id":"https://openalex.org/S4306402076","display_name":"Terrestrial Environment Research Center (University of Tsukuba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146399215","host_organization_name":"University of Tsukuba","host_organization_lineage":["https://openalex.org/I146399215"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1172/jci1594","doi":"https://doi.org/10.1172/jci1594","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci1594","pdf_url":"http://www.jci.org/articles/view/1594/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052961933.pdf","grobid_xml":"https://content.openalex.org/works/W2052961933.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W141676919","https://openalex.org/W1551929310","https://openalex.org/W1923677208","https://openalex.org/W1925248176","https://openalex.org/W1929009802","https://openalex.org/W1952404770","https://openalex.org/W1989324173","https://openalex.org/W2007737411","https://openalex.org/W2014767365","https://openalex.org/W2024907664","https://openalex.org/W2025458248","https://openalex.org/W2032278674","https://openalex.org/W2033429522","https://openalex.org/W2039847564","https://openalex.org/W2049831434","https://openalex.org/W2057471793","https://openalex.org/W2060468612","https://openalex.org/W2064801081","https://openalex.org/W2065501573","https://openalex.org/W2069371982","https://openalex.org/W2076645147","https://openalex.org/W2085456568","https://openalex.org/W2087016879","https://openalex.org/W2087429030","https://openalex.org/W2091193879","https://openalex.org/W2092740788","https://openalex.org/W2096773810","https://openalex.org/W2097884696","https://openalex.org/W2103933115","https://openalex.org/W2104585842","https://openalex.org/W2108544809","https://openalex.org/W2111038792","https://openalex.org/W2120870247","https://openalex.org/W2141238176","https://openalex.org/W2146046550","https://openalex.org/W2151522859","https://openalex.org/W2164664153","https://openalex.org/W2188028844","https://openalex.org/W2319850088","https://openalex.org/W2471216145","https://openalex.org/W4285719527","https://openalex.org/W6677857121","https://openalex.org/W6811603945","https://openalex.org/W6849026505"],"related_works":["https://openalex.org/W7097436306","https://openalex.org/W1983560687","https://openalex.org/W588733124","https://openalex.org/W2136041436","https://openalex.org/W2071251286","https://openalex.org/W2329620569","https://openalex.org/W2039907337","https://openalex.org/W2610329545","https://openalex.org/W2967994105","https://openalex.org/W1992869776"],"abstract_inverted_index":{"Insulin":[0],"resistance":[1,23,95],"is":[2],"often":[3],"associated":[4],"with":[5,10,116],"atherosclerotic":[6],"diseases":[7],"in":[8,28,48,53,63,74,83,86,100,114],"subjects":[9,115],"obesity":[11],"and":[12,41],"impaired":[13,78],"glucose":[14],"tolerance.":[15],"This":[16],"study":[17],"examined":[18],"the":[19,84,101,110],"effects":[20],"of":[21,36,103,112],"insulin":[22,37,94,117],"on":[24],"coronary":[25,104],"risk":[26,105],"factors":[27,106],"IRS-1":[29,49,64],"deficient":[30,50,65],"mice,":[31,76],"a":[32],"nonobese":[33],"animal":[34],"model":[35],"resistance.":[38,118],"Blood":[39],"pressure":[40],"plasma":[42,87],"triglyceride":[43,88],"levels":[44,89],"were":[45],"significantly":[46],"higher":[47],"mice":[51],"than":[52,73],"normal":[54,75],"mice.":[55,66],"Impaired":[56],"endothelium-dependent":[57],"vascular":[58],"relaxation":[59],"was":[60,71],"also":[61],"observed":[62],"Furthermore,":[67],"lipoprotein":[68],"lipase":[69],"activity":[70],"lower":[72],"suggesting":[77],"lipolysis":[79],"to":[80],"be":[81],"involved":[82],"increase":[85],"under":[90],"insulin-resistant":[91],"conditions.":[92],"Thus,":[93],"plays":[96],"an":[97],"important":[98],"role":[99],"clustering":[102],"which":[107],"may":[108],"accelerate":[109],"progression":[111],"atherosclerosis":[113]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}