{"id":"https://openalex.org/W2052954643","doi":"https://doi.org/10.1016/s0165-2478(01)00328-5","title":"Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4","display_name":"Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2052954643","doi":"https://doi.org/10.1016/s0165-2478(01)00328-5","mag":"2052954643","pmid":"https://pubmed.ncbi.nlm.nih.gov/11841848"},"language":"en","primary_location":{"id":"doi:10.1016/s0165-2478(01)00328-5","doi":"https://doi.org/10.1016/s0165-2478(01)00328-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-2478(01)00328-5","pdf_url":null,"source":{"id":"https://openalex.org/S71256826","display_name":"Immunology Letters","issn_l":"0165-2478","issn":["0165-2478","1879-0542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030508882","display_name":"Yoshinori Mita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshinori Mita","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan. ymita@pop.showa.gunma-u.ac.jp","First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan. ymita@pop.showa.gunma-u.ac.jp","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081943674","display_name":"Kunio Dobashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio Dobashi","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066611133","display_name":"Katsuaki Endou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuaki Endou","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103375533","display_name":"Tadayoshi Kawata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadayoshi Kawata","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037951571","display_name":"Yasuo Shimizu","orcid":"https://orcid.org/0000-0001-5411-7739","observed_orcids":["https://orcid.org/0000-0001-5411-7739"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Shimizu","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101112829","display_name":"Tsugio Nakazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsugio Nakazawa","raw_affiliation_strings":["School of Health Sciences, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Sciences, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111806390","display_name":"Masatomo Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatomo Mori","raw_affiliation_strings":["First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030508882"],"corresponding_institution_ids":["https://openalex.org/I165735259"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":null,"fwci":1.6865,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.83348308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"81","issue":"1","first_page":"71","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9079999923706055},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.972000002861023},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/th1-th2-cytokines","display_name":"Th1/Th2 cytokines","score":0.7919999957084656},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.8109999895095825},{"id":"https://openalex.org/keywords/innate-immune-recognition","display_name":"innate immune recognition","score":0.5830000042915344},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6913551092147827},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5727552175521851},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5690261125564575},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5532342195510864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5377865433692932},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.48181217908859253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45687922835350037},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.4449031949043274},{"id":"https://openalex.org/C119195557","wikidata":"https://www.wikidata.org/wiki/Q18039723","display_name":"Interleukin 19","level":5,"score":0.4414597153663635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43554747104644775},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.3850553035736084},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37738245725631714},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3304579257965088},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.09383803606033325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05662009119987488}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0165-2478(01)00328-5","doi":"https://doi.org/10.1016/s0165-2478(01)00328-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-2478(01)00328-5","pdf_url":null,"source":{"id":"https://openalex.org/S71256826","display_name":"Immunology Letters","issn_l":"0165-2478","issn":["0165-2478","1879-0542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology Letters","raw_type":"journal-article"},{"id":"pmid:11841848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11841848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W90703323","https://openalex.org/W114959479","https://openalex.org/W1483162601","https://openalex.org/W1561435056","https://openalex.org/W1563081817","https://openalex.org/W1655332043","https://openalex.org/W1856693839","https://openalex.org/W1901097018","https://openalex.org/W1918037725","https://openalex.org/W1991164200","https://openalex.org/W1996224887","https://openalex.org/W2014255303","https://openalex.org/W2014635586","https://openalex.org/W2017797666","https://openalex.org/W2025698614","https://openalex.org/W2033613405","https://openalex.org/W2035580122","https://openalex.org/W2046099042","https://openalex.org/W2054147111","https://openalex.org/W2066365885","https://openalex.org/W2078146109","https://openalex.org/W2084630030","https://openalex.org/W2123733931","https://openalex.org/W2141067630","https://openalex.org/W2145078103","https://openalex.org/W2168335646","https://openalex.org/W2253736588","https://openalex.org/W4312615442"],"related_works":["https://openalex.org/W2085965995","https://openalex.org/W1996224887","https://openalex.org/W1970839833","https://openalex.org/W2102464938","https://openalex.org/W1848628272","https://openalex.org/W2037118651","https://openalex.org/W2052648717","https://openalex.org/W2037338947","https://openalex.org/W2020564257","https://openalex.org/W4240944094"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}