{"id":"https://openalex.org/W2052899239","doi":"https://doi.org/10.2217/fmb.13.39","title":"Pharmacology of Polymyxins: New Insights into an \u2018Old\u2018 Class of Antibiotics","display_name":"Pharmacology of Polymyxins: New Insights into an \u2018Old\u2018 Class of Antibiotics","publication_year":2013,"publication_date":"2013-05-23","ids":{"openalex":"https://openalex.org/W2052899239","doi":"https://doi.org/10.2217/fmb.13.39","mag":"2052899239","pmid":"https://pubmed.ncbi.nlm.nih.gov/23701329","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3852176"},"language":"en","primary_location":{"id":"doi:10.2217/fmb.13.39","doi":"https://doi.org/10.2217/fmb.13.39","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmb.13.39","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3852176","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020748618","display_name":"Tony Velkov","orcid":"https://orcid.org/0000-0002-0017-7952","observed_orcids":["https://orcid.org/0000-0002-0017-7952"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tony Velkov","raw_affiliation_strings":["Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060920867","display_name":"Kade D. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kade D Roberts","raw_affiliation_strings":["Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073046394","display_name":"Roger L. Nation","orcid":"https://orcid.org/0000-0003-1492-8590","observed_orcids":["https://orcid.org/0000-0003-1492-8590"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roger L Nation","raw_affiliation_strings":["Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032907078","display_name":"Philip Evan Thompson","orcid":"https://orcid.org/0000-0002-5910-7625","observed_orcids":["https://orcid.org/0000-0002-5910-7625"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Philip E Thompson","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402427","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-7953-8230","observed_orcids":["https://orcid.org/0000-0001-7953-8230"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jian Li","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia","Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia. "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Drug Delivery, Disposition & Dynamics, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade Parkville 3052, Victoria, Australia. ","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100402427"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":null,"apc_paid":null,"fwci":1.5851,"has_fulltext":false,"cited_by_count":453,"citation_normalized_percentile":{"value":0.81521739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"8","issue":"6","first_page":"711","last_page":"724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.18230000138282776,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymyxins","display_name":"polymyxins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colistin","display_name":"colistin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.6589999794960022},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8610000014305115},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9610000252723694},{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":0.9980000257492065},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":1.0},{"id":"https://openalex.org/keywords/lipopeptide-antibiotics","display_name":"lipopeptide antibiotics","score":0.8180000185966492},{"id":"https://openalex.org/keywords/last-resort-antibiotics","display_name":"last-resort antibiotics","score":0.5419999957084656},{"id":"https://openalex.org/keywords/antibiotic-resistance-mechanisms","display_name":"antibiotic resistance mechanisms","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.8733236789703369},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.681859016418457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4305539131164551},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3812715411186218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3799821436405182},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3718903660774231},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3569473624229431}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016905","descriptor_name":"Gram-Negative Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2217/fmb.13.39","doi":"https://doi.org/10.2217/fmb.13.39","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fmb.13.39","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},{"id":"pmid:23701329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23701329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2951405","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3852176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3852176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3852176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Future Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2951405","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3852176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1468427885","display_name":"Targeting superbugs: discovery and development of new broad-spectrum lipopeptides","funder_award_id":"R01AI098771","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3273711892","display_name":"Optimizing Dosing of Colistin for Infections Resistant to all Other Antibiotics","funder_award_id":"R01AI070896","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5975211804","display_name":"Targeting MDR hetero-resistant Gram-negatives: PK/PD for rational combinations","funder_award_id":"R01AI079330","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W18840079","https://openalex.org/W1433217890","https://openalex.org/W1832530950","https://openalex.org/W1924202047","https://openalex.org/W1963646614","https://openalex.org/W1964141703","https://openalex.org/W1965496820","https://openalex.org/W1967459325","https://openalex.org/W1973063953","https://openalex.org/W1981142566","https://openalex.org/W1982047822","https://openalex.org/W1988515368","https://openalex.org/W1988595672","https://openalex.org/W2004918900","https://openalex.org/W2011909200","https://openalex.org/W2017758309","https://openalex.org/W2024956881","https://openalex.org/W2025280647","https://openalex.org/W2028695636","https://openalex.org/W2029091988","https://openalex.org/W2033065181","https://openalex.org/W2036456340","https://openalex.org/W2036492728","https://openalex.org/W2038305694","https://openalex.org/W2040736753","https://openalex.org/W2048048854","https://openalex.org/W2049890007","https://openalex.org/W2051334858","https://openalex.org/W2052211754","https://openalex.org/W2053881022","https://openalex.org/W2056400584","https://openalex.org/W2060577520","https://openalex.org/W2066560470","https://openalex.org/W2074066513","https://openalex.org/W2074068571","https://openalex.org/W2074185445","https://openalex.org/W2081960029","https://openalex.org/W2095037772","https://openalex.org/W2098161344","https://openalex.org/W2101273146","https://openalex.org/W2105838577","https://openalex.org/W2105929522","https://openalex.org/W2106050397","https://openalex.org/W2107050135","https://openalex.org/W2107352206","https://openalex.org/W2110117563","https://openalex.org/W2111842378","https://openalex.org/W2113410040","https://openalex.org/W2117992352","https://openalex.org/W2118734761","https://openalex.org/W2119596752","https://openalex.org/W2120061656","https://openalex.org/W2120266293","https://openalex.org/W2120409679","https://openalex.org/W2122863984","https://openalex.org/W2124245343","https://openalex.org/W2125825231","https://openalex.org/W2127833097","https://openalex.org/W2128136074","https://openalex.org/W2133316456","https://openalex.org/W2133444948","https://openalex.org/W2136653513","https://openalex.org/W2137081432","https://openalex.org/W2139382674","https://openalex.org/W2142207400","https://openalex.org/W2142947267","https://openalex.org/W2144767644","https://openalex.org/W2144783676","https://openalex.org/W2148455524","https://openalex.org/W2149483355","https://openalex.org/W2149556251","https://openalex.org/W2151999391","https://openalex.org/W2152420707","https://openalex.org/W2153732625","https://openalex.org/W2154556219","https://openalex.org/W2155833698","https://openalex.org/W2156447370","https://openalex.org/W2163732007","https://openalex.org/W2164032940","https://openalex.org/W2166348498","https://openalex.org/W2168485847","https://openalex.org/W2168502103","https://openalex.org/W2171780940","https://openalex.org/W2171857175","https://openalex.org/W2402663841","https://openalex.org/W4234317413","https://openalex.org/W4239532334","https://openalex.org/W4244732422","https://openalex.org/W4255310200"],"related_works":["https://openalex.org/W2530528252","https://openalex.org/W2965222207","https://openalex.org/W4399901195","https://openalex.org/W7073873453","https://openalex.org/W2004428159","https://openalex.org/W2964600569","https://openalex.org/W2965981848","https://openalex.org/W2318113092","https://openalex.org/W2066560470","https://openalex.org/W7108069335"],"abstract_inverted_index":{"Increasing":[0],"antibiotic":[1,37],"resistance":[2],"in":[3,7,29,71],"Gram-negative":[4,59,105],"bacteria,":[5],"particularly":[6],"Pseudomonas":[8],"aeruginosa,":[9],"Acinetobacter":[10],"baumannii":[11],"and":[12,41,79,83],"Klebsiella":[13],"pneumoniae,":[14],"presents":[15],"a":[16],"global":[17],"medical":[18],"challenge.":[19],"No":[20,89],"new":[21,108],"antibiotics":[22,109],"will":[23],"be":[24],"available":[25],"for":[26,52],"these":[27],"'superbugs'":[28],"the":[30,35,48,64,68,86,115,121,128],"near":[31],"future":[32],"due":[33],"to":[34,98],"dry":[36],"discovery":[38],"pipeline.":[39],"Colistin":[40],"polymyxin":[42,73],"B":[43],"are":[44],"increasingly":[45],"used":[46],"as":[47],"last-line":[49],"therapeutic":[50],"options":[51],"treatment":[53],"of":[54,76,118,123,130],"infections":[55],"caused":[56],"by":[57],"multidrug-resistant":[58],"bacteria.":[60],"This":[61],"article":[62],"surveys":[63],"significant":[65],"progress":[66],"over":[67],"last":[69],"decade":[70],"understanding":[72],"chemistry,":[74],"mechanisms":[75],"antibacterial":[77],"activity":[78],"resistance,":[80],"structure-activity":[81,95],"relationships":[82],"pharmacokinetics/pharmacodynamics.":[84],"In":[85],"'Bad":[87],"Bugs,":[88],"Drugs'":[90],"era,":[91],"we":[92,112],"must":[93,113],"pursue":[94],"relationship-based":[96],"approaches":[97],"develop":[99],"novel":[100],"polymyxin-like":[101],"lipopeptides":[102],"targeting":[103],"polymyxin-resistant":[104],"'superbugs'.":[106],"Before":[107],"become":[110],"available,":[111],"optimize":[114],"clinical":[116],"use":[117],"polymyxins":[119],"through":[120],"application":[122],"pharmacokinetic/pharmacodynamic":[124],"principles,":[125],"thereby":[126],"minimizing":[127],"development":[129],"resistance.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":57},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":49},{"year":2019,"cited_by_count":47},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":46},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":18}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}