{"id":"https://openalex.org/W2052896972","doi":"https://doi.org/10.1016/0306-4522(96)00052-8","title":"Thyroid hormonal modulation of the binding and activity of the GABAA receptor complex of brain","display_name":"Thyroid hormonal modulation of the binding and activity of the GABAA receptor complex of brain","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2052896972","doi":"https://doi.org/10.1016/0306-4522(96)00052-8","mag":"2052896972","pmid":"https://pubmed.ncbi.nlm.nih.gov/8809792"},"language":"en","primary_location":{"id":"doi:10.1016/0306-4522(96)00052-8","doi":"https://doi.org/10.1016/0306-4522(96)00052-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0306-4522(96)00052-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/0306452296000528/pdf","source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/0306452296000528/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089873563","display_name":"Joseph V. Martin","orcid":"https://orcid.org/0000-0003-3757-3091","observed_orcids":["https://orcid.org/0000-0003-3757-3091"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.V. Martin","raw_affiliation_strings":["Department of Biology, Rutgers University, Camden, NJ 08102, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rutgers University, Camden, NJ 08102, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D.B. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.B. Williams","raw_affiliation_strings":["Department of Biology, Rutgers University, Camden, NJ 08102, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rutgers University, Camden, NJ 08102, U.S.A","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001374580","display_name":"RAINA FITZGERALD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.M. Fitzgerald","raw_affiliation_strings":["Department of Biology, Rutgers University, Camden, NJ 08102, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Rutgers University, Camden, NJ 08102, U.S.A","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086757768","display_name":"Haesook K. Im","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156900","display_name":"CNS Research (United States)","ror":"https://ror.org/05a9nb826","country_code":"US","type":"company","lineage":["https://openalex.org/I4210156900"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.K. Im","raw_affiliation_strings":["The Upjohn Company, CNS Research, 7251-209-431, 301 Henrietta St., Kalamazoo, MI 49001, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Upjohn Company, CNS Research, 7251-209-431, 301 Henrietta St., Kalamazoo, MI 49001, U.S.A","institution_ids":["https://openalex.org/I4210156900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110106012","display_name":"Philip F. VonVoigtlander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156900","display_name":"CNS Research (United States)","ror":"https://ror.org/05a9nb826","country_code":"US","type":"company","lineage":["https://openalex.org/I4210156900"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.F. Vonvoigtlander","raw_affiliation_strings":["The Upjohn Company, CNS Research, 7251-209-431, 301 Henrietta St., Kalamazoo, MI 49001, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Upjohn Company, CNS Research, 7251-209-431, 301 Henrietta St., Kalamazoo, MI 49001, U.S.A","institution_ids":["https://openalex.org/I4210156900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089873563"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.9448,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.71908516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"73","issue":"3","first_page":"705","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.968999981880188},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":1.0},{"id":"https://openalex.org/keywords/chloride-currents","display_name":"chloride currents","score":0.5889999866485596},{"id":"https://openalex.org/keywords/flumazenil","display_name":"flumazenil","score":0.800000011920929},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.621999979019165},{"id":"https://openalex.org/keywords/brain-membranes","display_name":"brain membranes","score":0.5450000166893005},{"id":"https://openalex.org/keywords/t-butylbicyclophosphorothionate","display_name":"t-butylbicyclophosphorothionate","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.8014485239982605},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5935996174812317},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5198355317115784},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5192925333976746},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4554126560688019},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43191784620285034},{"id":"https://openalex.org/C2779571634","wikidata":"https://www.wikidata.org/wiki/Q422106","display_name":"Thyroid hormones","level":3,"score":0.41704773902893066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3411800265312195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2927182912826538},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2785261869430542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27310049533843994}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0306-4522(96)00052-8","doi":"https://doi.org/10.1016/0306-4522(96)00052-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0306-4522(96)00052-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/0306452296000528/pdf","source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:8809792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8809792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0306-4522(96)00052-8","doi":"https://doi.org/10.1016/0306-4522(96)00052-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0306-4522(96)00052-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/0306452296000528/pdf","source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G731411405","display_name":"RUI:  Thyroid Hormone Regulation of the GABAa Receptor and  Sleep/Waking EEG","funder_award_id":"9412109","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052896972.pdf","grobid_xml":"https://content.openalex.org/works/W2052896972.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W63412652","https://openalex.org/W74306928","https://openalex.org/W159198934","https://openalex.org/W234378752","https://openalex.org/W1751807524","https://openalex.org/W1887384960","https://openalex.org/W1952984479","https://openalex.org/W1978342290","https://openalex.org/W1983967908","https://openalex.org/W1985993417","https://openalex.org/W1986006697","https://openalex.org/W1987266067","https://openalex.org/W1988921565","https://openalex.org/W1993427526","https://openalex.org/W1998277191","https://openalex.org/W1998917248","https://openalex.org/W2001147365","https://openalex.org/W2002110177","https://openalex.org/W2006442321","https://openalex.org/W2007453287","https://openalex.org/W2009051740","https://openalex.org/W2009358137","https://openalex.org/W2009415563","https://openalex.org/W2009667219","https://openalex.org/W2012618926","https://openalex.org/W2017316214","https://openalex.org/W2023468172","https://openalex.org/W2026846044","https://openalex.org/W2037952293","https://openalex.org/W2043598410","https://openalex.org/W2045155944","https://openalex.org/W2048450600","https://openalex.org/W2048602049","https://openalex.org/W2049403597","https://openalex.org/W2050355091","https://openalex.org/W2051024351","https://openalex.org/W2051319927","https://openalex.org/W2057911468","https://openalex.org/W2059318434","https://openalex.org/W2059864318","https://openalex.org/W2060586131","https://openalex.org/W2061658026","https://openalex.org/W2062594762","https://openalex.org/W2068650383","https://openalex.org/W2071189066","https://openalex.org/W2072517364","https://openalex.org/W2079590715","https://openalex.org/W2082364522","https://openalex.org/W2083256398","https://openalex.org/W2083447043","https://openalex.org/W2084798483","https://openalex.org/W2087427512","https://openalex.org/W2094888887","https://openalex.org/W2095016919","https://openalex.org/W2114871136","https://openalex.org/W2120115003","https://openalex.org/W2132009630","https://openalex.org/W2134876647","https://openalex.org/W2136743022","https://openalex.org/W2162067039","https://openalex.org/W2170028141","https://openalex.org/W2176076159","https://openalex.org/W2254314688","https://openalex.org/W2335783627","https://openalex.org/W2398132978","https://openalex.org/W2406126144","https://openalex.org/W2410833260","https://openalex.org/W4237393322","https://openalex.org/W4245117662","https://openalex.org/W6680135351","https://openalex.org/W6691495706","https://openalex.org/W6702799390","https://openalex.org/W6712525709"],"related_works":["https://openalex.org/W2794604166","https://openalex.org/W2083774514","https://openalex.org/W2082364522","https://openalex.org/W2312988172","https://openalex.org/W2073748679","https://openalex.org/W2094345187","https://openalex.org/W2327885578","https://openalex.org/W2090516871","https://openalex.org/W2090084100","https://openalex.org/W2106116921"],"abstract_inverted_index":{"Thyroid":[0],"hormones,":[1],"which":[2],"are":[3,128],"known":[4,129],"to":[5,15,49,130],"act":[6,156],"by":[7,73,103,120],"genomic":[8],"mechanisms":[9,145],"in":[10,26,66,92,133,153],"peripheral":[11],"tissues,":[12],"were":[13],"found":[14],"influence":[16],"the":[17,22,37,45,59,110,121,140],"binding":[18,38],"and":[19,33,116,137,155],"function":[20],"of":[21,31,39,58,81,86,100,146],"GABAA":[23,46,88,158],"receptor":[24,47,89],"complex":[25],"brain":[27,53,68,154],"membranes.":[28],"Submicromolar":[29],"concentrations":[30,57],"triiodothyronine":[32],"thyroxine":[34],"stereospecifically":[35],"stimulated":[36],"[35S]t-butylbicyclophosphorothionate":[40],"(a":[41],"convulsant":[42],"ligand":[43],"for":[44],"complex)":[48],"highly":[50],"washed":[51],"rat":[52],"membranes,":[54],"while":[55],"higher":[56],"hormones":[60,127,141],"inhibited":[61,72],"radioligand":[62],"binding.":[63],"GABA-stimulated":[64],"36Cl-flux":[65],"isolated":[67],"membrane":[69],"sacs":[70],"was":[71,117],"L-triiodothyronine":[74],"with":[75],"a":[76],"half-maximally":[77],"inhibitory":[78],"concentration":[79],"(IC50)":[80],"10(-7)":[82],"M.":[83],"Patch-clamp":[84],"analysis":[85],"recombinant":[87],"subunits":[90],"expressed":[91],"human":[93],"embryonic":[94],"kidney-293":[95],"cells":[96],"showed":[97],"an":[98],"inhibition":[99],"chloride":[101],"currents":[102],"thyroid":[104,126],"hormones.":[105],"This":[106],"effect":[107],"required":[108],"only":[109],"alpha":[111],"1":[112],"beta":[113],"2":[114],"subunits,":[115],"not":[118],"blocked":[119],"benzodiazepine":[122],"antagonist":[123],"flumazenil.":[124],"Since":[125],"be":[131],"concentrated":[132],"nerve":[134],"terminal":[135],"preparations":[136],"subsequently":[138],"released,":[139],"may":[142],"have":[143],"non-genomic":[144],"action":[147],"as":[148],"putative":[149],"neurotransmitters":[150],"or":[151],"neuromodulators":[152],"through":[157],"receptors.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}