{"id":"https://openalex.org/W2052883386","doi":"https://doi.org/10.1074/jbc.m110.212514","title":"Role of YKL-40 in the Angiogenesis, Radioresistance, and Progression of Glioblastoma","display_name":"Role of YKL-40 in the Angiogenesis, Radioresistance, and Progression of Glioblastoma","publication_year":2011,"publication_date":"2011-03-09","ids":{"openalex":"https://openalex.org/W2052883386","doi":"https://doi.org/10.1074/jbc.m110.212514","mag":"2052883386","pmid":"https://pubmed.ncbi.nlm.nih.gov/21385870","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3083166"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.212514","doi":"https://doi.org/10.1074/jbc.m110.212514","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.212514","pdf_url":"http://www.jbc.org/article/S0021925820858207/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820858207/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089222986","display_name":"Ralph Francescone","orcid":"https://orcid.org/0000-0002-3149-6825","observed_orcids":["https://orcid.org/0000-0002-3149-6825"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A. Francescone","raw_affiliation_strings":["Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA","From the Molecular and Cellular Biology Program, Morrill Science Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"From the Molecular and Cellular Biology Program, Morrill Science Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037548760","display_name":"Steve J. Scully","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Scully","raw_affiliation_strings":["From the Molecular and Cellular Biology Program, Morrill Science Center, and","the Pioneer Valley Life Sciences Institute, University of Massachusetts Amherst, Springfield, Massachusetts 01107, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular and Cellular Biology Program, Morrill Science Center, and","institution_ids":[]},{"raw_affiliation_string":"the Pioneer Valley Life Sciences Institute, University of Massachusetts Amherst, Springfield, Massachusetts 01107, and","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005159111","display_name":"Michael Faibish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Faibish","raw_affiliation_strings":["From the Molecular and Cellular Biology Program, Morrill Science Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular and Cellular Biology Program, Morrill Science Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015448130","display_name":"Sherry L. Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sherry L. Taylor","raw_affiliation_strings":["the Departments of Neurosurgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurosurgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080459193","display_name":"Dennis S. Oh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis Oh","raw_affiliation_strings":["the Departments of Neurosurgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Neurosurgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110070285","display_name":"Luis A. Moral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1338449461","display_name":"Baystate Medical Center","ror":"https://ror.org/01q2nz307","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1338449461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Moral","raw_affiliation_strings":["Departments of Pathology, Baystate Medical Center, Tufts University, Springfield, Massachusetts 01199"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Baystate Medical Center, Tufts University, Springfield, Massachusetts 01199","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1338449461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100733278","display_name":"Wei Yan","orcid":"https://orcid.org/0000-0003-0619-5876","observed_orcids":["https://orcid.org/0000-0003-0619-5876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Yan","raw_affiliation_strings":["From the Molecular and Cellular Biology Program, Morrill Science Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular and Cellular Biology Program, Morrill Science Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brooke Bentley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Bentley","raw_affiliation_strings":["the Pioneer Valley Life Sciences Institute, University of Massachusetts Amherst, Springfield, Massachusetts 01107, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Pioneer Valley Life Sciences Institute, University of Massachusetts Amherst, Springfield, Massachusetts 01107, and","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069452355","display_name":"Rong Shao","orcid":"https://orcid.org/0000-0002-4905-4064","observed_orcids":["https://orcid.org/0000-0002-4905-4064"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rong Shao","raw_affiliation_strings":["From the Molecular and Cellular Biology Program, Morrill Science Center, and","the Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003,","the Pioneer Valley Life Sciences Institute, University of Massachusetts Amherst, Springfield, Massachusetts 01107, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular and Cellular Biology Program, Morrill Science Center, and","institution_ids":[]},{"raw_affiliation_string":"the Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003,","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"the Pioneer Valley Life Sciences Institute, University of Massachusetts Amherst, Springfield, Massachusetts 01107, and","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069452355"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":7.1802,"has_fulltext":true,"cited_by_count":256,"citation_normalized_percentile":{"value":0.98388667,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"286","issue":"17","first_page":"15332","last_page":"15343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.2223999947309494,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ykl-40","display_name":"YKL-40","score":1.0},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/integrin-alphavbeta5","display_name":"integrin \u03b1v\u03b25","score":0.9750000238418579},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5450000166893005},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5789999961853027},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8986575603485107},{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.7493004202842712},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7350239753723145},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5638496279716492},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5619290471076965},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.5065737962722778},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.46398475766181946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.457202285528183},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4482309818267822},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3264467120170593},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27452269196510315},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2659545838832855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17609068751335144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071451","descriptor_name":"Chitinase-3-Like Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m110.212514","doi":"https://doi.org/10.1074/jbc.m110.212514","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.212514","pdf_url":"http://www.jbc.org/article/S0021925820858207/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2343343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3083166","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3083166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3083166","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21385870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21385870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.212514","doi":"https://doi.org/10.1074/jbc.m110.212514","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.212514","pdf_url":"http://www.jbc.org/article/S0021925820858207/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G765192142","display_name":"Role of a novel angiogenic factor, YKL-40, in breast cancer progression","funder_award_id":"R01CA120659","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052883386.pdf","grobid_xml":"https://content.openalex.org/works/W2052883386.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1507160997","https://openalex.org/W1589544688","https://openalex.org/W1756949381","https://openalex.org/W1783580437","https://openalex.org/W1860646036","https://openalex.org/W1963566235","https://openalex.org/W1967600348","https://openalex.org/W1969410032","https://openalex.org/W1977999028","https://openalex.org/W2018512891","https://openalex.org/W2020065664","https://openalex.org/W2027072680","https://openalex.org/W2029482740","https://openalex.org/W2031525727","https://openalex.org/W2036044314","https://openalex.org/W2044823409","https://openalex.org/W2046609279","https://openalex.org/W2049079346","https://openalex.org/W2049642657","https://openalex.org/W2058365984","https://openalex.org/W2058774374","https://openalex.org/W2060713654","https://openalex.org/W2074198216","https://openalex.org/W2075026880","https://openalex.org/W2082833890","https://openalex.org/W2088037057","https://openalex.org/W2088634583","https://openalex.org/W2090785782","https://openalex.org/W2100571347","https://openalex.org/W2107406789","https://openalex.org/W2110676091","https://openalex.org/W2111080918","https://openalex.org/W2111946204","https://openalex.org/W2112018994","https://openalex.org/W2114021514","https://openalex.org/W2117736493","https://openalex.org/W2122872071","https://openalex.org/W2124657377","https://openalex.org/W2125154703","https://openalex.org/W2125407494","https://openalex.org/W2129934943","https://openalex.org/W2131093545","https://openalex.org/W2131933252","https://openalex.org/W2133492954","https://openalex.org/W2133628830","https://openalex.org/W2140088548","https://openalex.org/W2141046053","https://openalex.org/W2143851656","https://openalex.org/W2144219560","https://openalex.org/W2148894332","https://openalex.org/W2158718443","https://openalex.org/W2159057646","https://openalex.org/W2168414172","https://openalex.org/W2169439533","https://openalex.org/W2170367762","https://openalex.org/W4255042798"],"related_works":["https://openalex.org/W1578195172","https://openalex.org/W2339683255","https://openalex.org/W2159057646","https://openalex.org/W2027072680","https://openalex.org/W128373980","https://openalex.org/W7095417393","https://openalex.org/W2024148673","https://openalex.org/W1984790412","https://openalex.org/W2186036549","https://openalex.org/W2598992061"],"abstract_inverted_index":{"Glioblastoma":[0],"is":[1,18],"one":[2],"of":[3,35,56,86,93,121,141,157],"the":[4,49,54,175],"most":[5],"fatal":[6],"cancers,":[7],"characterized":[8],"by":[9,177],"a":[10,15,28,102,161,188],"strong":[11],"vascularized":[12],"phenotype.":[13],"YKL-40,":[14,164],"secreted":[16],"glycoprotein,":[17],"overexpressed":[19],"in":[20,37,53,67,152],"patients":[21],"with":[22],"glioblastomas":[23,159],"and":[24,61,72,75,97,100,109,115,134,150,166,183,185],"has":[25],"potential":[26],"as":[27],"novel":[29],"tumor":[30,59,147,181,192],"biomarker.":[31],"The":[32],"molecular":[33],"mechanisms":[34,176],"YKL-40":[36,51,63,74,90,125,142,179],"glioblastoma":[38,68],"development,":[39],"however,":[40],"are":[41],"poorly":[42],"understood.":[43],"Here,":[44],"we":[45],"aimed":[46],"to":[47,107,112],"elucidate":[48],"role":[50],"plays":[52],"regulation":[55],"VEGF":[57,65,76,87,114],"expression,":[58],"angiogenesis,":[60,149],"radioresistance.":[62],"up-regulated":[64,88],"expression":[66,126,145],"cell":[69,80,129,138],"line":[70],"U87,":[71],"both":[73],"synergistically":[77],"promote":[78],"endothelial":[79,137],"angiogenesis.":[81,117,139],"Interestingly,":[82],"long":[83],"term":[84],"inhibition":[85],"YKL-40.":[89],"induced":[91],"coordination":[92],"membrane":[94],"receptor":[95],"syndecan-1":[96],"integrin":[98],"\u03b1v\u03b25,":[99],"triggered":[101],"signaling":[103],"cascade":[104],"through":[105,131],"FAK(397)":[106],"ERK-1":[108],"ERK-2,":[110],"leading":[111],"elevated":[113],"enhanced":[116],"In":[118],"addition,":[119],"\u03b3-irradiation":[120],"U87":[122],"cells":[123],"increased":[124],"that":[127],"protects":[128],"death":[130],"AKT":[132],"activation":[133],"also":[135],"enhances":[136],"Blockade":[140],"activity":[143],"or":[144],"decreased":[146],"growth,":[148],"metastasis":[151],"xenografted":[153],"animals.":[154],"Immunohistochemical":[155],"analysis":[156],"human":[158],"revealed":[160],"correlation":[162],"between":[163],"VEGF,":[165],"patient":[167],"survival.":[168],"These":[169],"findings":[170],"have":[171],"shed":[172],"light":[173],"on":[174],"which":[178],"promotes":[180],"angiogenesis":[182],"malignancy,":[184],"thus":[186],"provide":[187],"therapeutic":[189],"target":[190],"for":[191],"treatment.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}