{"id":"https://openalex.org/W2052883017","doi":"https://doi.org/10.1111/j.1365-2249.1990.tb08101.x","title":"The inductive effect of interleukin-4 on IgG4 and IgE synthesis in human peripheral blood lymphocytes","display_name":"The inductive effect of interleukin-4 on IgG4 and IgE synthesis in human peripheral blood lymphocytes","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W2052883017","doi":"https://doi.org/10.1111/j.1365-2249.1990.tb08101.x","mag":"2052883017","pmid":"https://pubmed.ncbi.nlm.nih.gov/2107992","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534964"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.1990.tb08101.x","doi":"https://doi.org/10.1111/j.1365-2249.1990.tb08101.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.1990.tb08101.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534964","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A ISHIZAKA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A ISHIZAKA","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041941752","display_name":"Yukio Sakiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y SAKIYAMA","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M NAKANISHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M NAKANISHI","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111710964","display_name":"Kazuhiro Tomizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K TOMIZAWA","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072512300","display_name":"Eiki Oshika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E OSHIKA","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K KOJIMA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K KOJIMA","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y TAGUCHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y TAGUCHI","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E KANDIL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E KANDIL","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033676330","display_name":"Shuzo Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S MATSUMOTO","raw_affiliation_strings":["Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatres, Hokkuido, University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":4.7344,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.95776018,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"79","issue":"3","first_page":"392","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/igg4","display_name":"IgG4","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.9639999866485596},{"id":"https://openalex.org/keywords/igg-subclasses","display_name":"IgG subclasses","score":0.9539999961853027},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.875},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/anti-il-4-monoclonal-antibody","display_name":"anti-IL-4 monoclonal antibody","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.8062531352043152},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6338627338409424},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.5766809582710266},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.49901461601257324},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.47474342584609985},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.46208852529525757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4367212653160095},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.40929827094078064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3254709243774414},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.26955103874206543},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13170528411865234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0948096513748169}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.1990.tb08101.x","doi":"https://doi.org/10.1111/j.1365-2249.1990.tb08101.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.1990.tb08101.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1534964","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:2107992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2107992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1534964","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1481437690","https://openalex.org/W1481618808","https://openalex.org/W1594970574","https://openalex.org/W1597438058","https://openalex.org/W1975436067","https://openalex.org/W1978651681","https://openalex.org/W1979492370","https://openalex.org/W1980113529","https://openalex.org/W1999515470","https://openalex.org/W2010290590","https://openalex.org/W2013571259","https://openalex.org/W2023991540","https://openalex.org/W2033182697","https://openalex.org/W2041647537","https://openalex.org/W2052543535","https://openalex.org/W2082366823","https://openalex.org/W2093107928","https://openalex.org/W2093385116","https://openalex.org/W2114769066","https://openalex.org/W2119338471","https://openalex.org/W2120422181","https://openalex.org/W2123733931","https://openalex.org/W2159127743","https://openalex.org/W2164412635","https://openalex.org/W2412083084","https://openalex.org/W2418483299"],"related_works":["https://openalex.org/W2159127743","https://openalex.org/W2062319893","https://openalex.org/W1964435679","https://openalex.org/W1979492370","https://openalex.org/W1831711338","https://openalex.org/W2023991540","https://openalex.org/W2160410700","https://openalex.org/W2085209020","https://openalex.org/W2013571259","https://openalex.org/W7099685133"],"abstract_inverted_index":{"Using":[0],"murine":[1],"monoclonal":[2,87],"antibodies":[3],"against":[4],"human":[5,17,29],"IgG":[6,18,37,102],"subclasses,":[7],"specific":[8],"and":[9,69,84,104],"sensitive":[10],"ELISAs":[11],"assay":[12],"to":[13,48],"quantify":[14],"the":[15,34,49],"four":[16],"subclasses":[19,38],"in":[20,59,77,100],"cell":[21],"culture":[22],"supernatants":[23],"were":[24],"established.":[25],"The":[26],"effect":[27,65],"of":[28,36,51],"recombinant":[30,82],"interleukin-4":[31],"(IL-4)":[32],"on":[33,66],"regulation":[35],"by":[39,81],"normal":[40],"peripheral":[41],"blood":[42],"lymphocytes":[43],"was":[44,75],"investigated.":[45],"In":[46],"addition":[47],"enhancement":[50],"IgE":[52,105],"synthesis,":[53],"IL-4":[54,62,86,94],"preferentially":[55],"induced":[56],"IgG4":[57,73],"synthesis":[58],"vitro,":[60],"whereas":[61],"had":[63],"no":[64],"IgG1,":[67],"IgG2,":[68],"IgG3":[70],"synthesis.":[71,106],"IL-4-induced":[72],"production":[74],"blocked":[76],"a":[78],"dose-dependent":[79],"manner":[80],"interferon-gamma":[83],"anti-human":[85],"antibody.":[88],"Collectively,":[89],"this":[90],"data":[91],"indicates":[92],"that":[93],"plays":[95],"an":[96],"important":[97],"regulatory":[98],"role":[99],"both":[101],"subclass":[103]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}