{"id":"https://openalex.org/W2052844055","doi":"https://doi.org/10.1039/p19740001326","title":"Biosynthesis of terpenes and steroids. Part IX. The sterols of some mutant yeasts and their relationship to the biosynthesis of ergosterol","display_name":"Biosynthesis of terpenes and steroids. Part IX. The sterols of some mutant yeasts and their relationship to the biosynthesis of ergosterol","publication_year":1974,"publication_date":"1974-01-01","ids":{"openalex":"https://openalex.org/W2052844055","doi":"https://doi.org/10.1039/p19740001326","mag":"2052844055","pmid":"https://pubmed.ncbi.nlm.nih.gov/4604164"},"language":"en","primary_location":{"id":"doi:10.1039/p19740001326","doi":"https://doi.org/10.1039/p19740001326","is_oa":false,"landing_page_url":"https://doi.org/10.1039/p19740001326","pdf_url":null,"source":{"id":"https://openalex.org/S955628534","display_name":"Journal of the Chemical Society Perkin Transactions 1","issn_l":"1364-5463","issn":["1364-5463","1470-4358","1472-7781","2050-8263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chemical Society, Perkin Transactions 1","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016045140","display_name":"Derek H. R. Barton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derek H. R. Barton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111778171","display_name":"John E. T. Corrie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John E. T. Corrie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046736959","display_name":"David A. Widdowson","orcid":"https://orcid.org/0000-0002-8930-3045","observed_orcids":["https://orcid.org/0000-0002-8930-3045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Widdowson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027241044","display_name":"Martin Bard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Bard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113690112","display_name":"Robin A. Woods","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin A. Woods","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0419,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.9177613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":"0","first_page":"1326","last_page":"1326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.49799999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.49799999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.45649999380111694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ergosterol-biosynthesis","display_name":"ergosterol biosynthesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sterol-biosynthesis","display_name":"sterol biosynthesis","score":0.828000009059906},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae-mutants","display_name":"Saccharomyces cerevisiae mutants","score":0.8429999947547913},{"id":"https://openalex.org/keywords/yeast-sterols","display_name":"yeast sterols","score":0.7689999938011169},{"id":"https://openalex.org/keywords/double-bond-formation","display_name":"double bond formation","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.9373468160629272},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7437363862991333},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6757853031158447},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6506294012069702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.643538236618042},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6054459810256958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5791247487068176},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.5690510869026184},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.5530098080635071},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5320860743522644},{"id":"https://openalex.org/C44937612","wikidata":"https://www.wikidata.org/wiki/Q212364","display_name":"Terpene","level":2,"score":0.47455960512161255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14702525734901428},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12010085582733154},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.1150948703289032},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009904","descriptor_name":"Optical Rotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/p19740001326","doi":"https://doi.org/10.1039/p19740001326","is_oa":false,"landing_page_url":"https://doi.org/10.1039/p19740001326","pdf_url":null,"source":{"id":"https://openalex.org/S955628534","display_name":"Journal of the Chemical Society Perkin Transactions 1","issn_l":"1364-5463","issn":["1364-5463","1470-4358","1472-7781","2050-8263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chemical Society, Perkin Transactions 1","raw_type":"journal-article"},{"id":"pmid:4604164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4604164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chemical Society. Perkin transactions 1","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2062871290","https://openalex.org/W2015360709","https://openalex.org/W2417203615","https://openalex.org/W2002672521","https://openalex.org/W1521897022","https://openalex.org/W1969731305","https://openalex.org/W1986289207","https://openalex.org/W2416122797","https://openalex.org/W2059439289","https://openalex.org/W2023119341"],"abstract_inverted_index":{"The":[0,26,55],"sterols":[1,57],"of":[2,6,28,37,45],"four":[3],"mutant":[4],"strains":[5],"Saccharomyces":[7],"cerevisiae":[8],"have":[9,17,62,93],"been":[10,18,63,95],"isolated":[11,64,96],"and":[12,14,48,51,65,83,87,97],"characterised":[13],"the":[15,21,29,35,38,43,46,52],"mutations":[16,30],"related":[19],"to":[20,32],"pathway":[22],"for":[23],"ergosterol":[24],"biosynthesis.":[25],"effects":[27],"are":[31],"block,":[33],"respectively,":[34],"introduction":[36,44],"side":[39],"chain":[40],"methyl":[41],"group,":[42],"5,6-":[47],"22,23-double":[49],"bonds,":[50],"\u03948\u2192\u03947":[53],"isomerisation.":[54],"following":[56],"previously":[58,91],"unreported":[59],"in":[60],"yeast":[61],"characterised:":[66],"cholesta-5,7,24-trien-3\u03b2-ol":[67],"(2;":[68],"R":[69,75,80],"=":[70,76,81],"H),":[71,77,82],"ergost-8-en-3\u03b2-ol,":[72],"ergosta-8,22-dien-3\u03b2-ol":[73],"(5;":[74],"ergosta-5,8,22-trien-3\u03b2-ol":[78],"(6;":[79],"ergosta-5,7-dien-3\u03b2-ol.":[84],"Cholesta-5,7,22,24-tetraen-3\u03b2-ol,":[85],"ergosta-8,22,24(28)-trien-3\u03b2-ol,":[86],"ergosta-8,14,24(28)-trien-3\u03b2-ol,":[88],"which":[89],"were":[90],"unknown,":[92],"also":[94],"characterised.":[98]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}