{"id":"https://openalex.org/W2052825002","doi":"https://doi.org/10.1371/journal.pone.0052879","title":"The Effect of the Creatine Analogue Beta-guanidinopropionic Acid on Energy Metabolism: A Systematic Review","display_name":"The Effect of the Creatine Analogue Beta-guanidinopropionic Acid on Energy Metabolism: A Systematic Review","publication_year":2013,"publication_date":"2013-01-09","ids":{"openalex":"https://openalex.org/W2052825002","doi":"https://doi.org/10.1371/journal.pone.0052879","mag":"2052825002","pmid":"https://pubmed.ncbi.nlm.nih.gov/23326362","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3541392"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0052879","doi":"https://doi.org/10.1371/journal.pone.0052879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0052879","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052879&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052879&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003364341","display_name":"Inge Oudman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Inge Oudman","raw_affiliation_strings":["Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. i.oudman@amc.nl","Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. i.oudman@amc.nl","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055042810","display_name":"Joseph F. Clark","orcid":"https://orcid.org/0009-0000-0295-0083","observed_orcids":["https://orcid.org/0009-0000-0295-0083"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph F. Clark","raw_affiliation_strings":["Department of Neurology, University of Cincinnati, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054890844","display_name":"Lizzy M. Brewster","orcid":"https://orcid.org/0000-0002-7434-0038","observed_orcids":["https://orcid.org/0000-0002-7434-0038"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lizzy M. Brewster","raw_affiliation_strings":["Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands","Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003364341"],"corresponding_institution_ids":["https://openalex.org/I2802928900"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.8746,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.63829787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"e52879","last_page":"e52879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-guanidinopropionic-acid","display_name":"beta-guanidinopropionic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.675000011920929},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8889999985694885},{"id":"https://openalex.org/keywords/skeletal-muscle-fatigue","display_name":"skeletal muscle fatigue","score":0.5389999747276306},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.8289999961853027},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.6159999966621399},{"id":"https://openalex.org/keywords/phosphocreatine-depletion","display_name":"phosphocreatine depletion","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.8696596622467041},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.6878757476806641},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5949438810348511},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.566379725933075},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.5223002433776855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4963224530220032},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4771004319190979},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4532613754272461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44181907176971436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4309196472167969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37880420684814453},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3776538670063019},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.3586500287055969}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0052879","doi":"https://doi.org/10.1371/journal.pone.0052879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0052879","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052879&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2547601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3541392","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3541392","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3541392","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23326362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23326362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/e31b316c-aac0-4b5b-952e-10ee6fe7d3b3","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/the-effect-of-the-creatine-analogue-betaguanidinopropionic-acid-on-energy-metabolism-a-systematic-review(e31b316c-aac0-4b5b-952e-10ee6fe7d3b3).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 8(1). Public Library of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5a993578a6e8435fb83289ce07f1eae3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5a993578a6e8435fb83289ce07f1eae3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 1, p e52879 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/114807","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Effect_of_the_Creatine_Analogue_Beta_guanidinopropionic_Acid_on_Energy_Metabolism_A_Systematic_Review__/114807","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/414492f8-1d28-4eb8-afe9-5af12152630b","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/414492f8-1d28-4eb8-afe9-5af12152630b","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oudman, I, Clark, J F & Brewster, L M 2013, 'The effect of the creatine analogue beta-guanidinopropionic acid on energy metabolism: a systematic review', PLoS ONE, vol. 8, no. 1, pp. e52879. https://doi.org/10.1371/journal.pone.0052879","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0052879","doi":"https://doi.org/10.1371/journal.pone.0052879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0052879","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052879&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052825002.pdf","grobid_xml":"https://content.openalex.org/works/W2052825002.grobid-xml"},"referenced_works_count":157,"referenced_works":["https://openalex.org/W105155487","https://openalex.org/W112805359","https://openalex.org/W118878972","https://openalex.org/W143533546","https://openalex.org/W185383216","https://openalex.org/W288226753","https://openalex.org/W307714630","https://openalex.org/W817510028","https://openalex.org/W1502889375","https://openalex.org/W1520972807","https://openalex.org/W1540539263","https://openalex.org/W1564178578","https://openalex.org/W1599633780","https://openalex.org/W1762977483","https://openalex.org/W1831649208","https://openalex.org/W1849159432","https://openalex.org/W1889076015","https://openalex.org/W1900048383","https://openalex.org/W1914938751","https://openalex.org/W1965425687","https://openalex.org/W1968628358","https://openalex.org/W1969912754","https://openalex.org/W1972719019","https://openalex.org/W1973402633","https://openalex.org/W1974263793","https://openalex.org/W1983461151","https://openalex.org/W1986737365","https://openalex.org/W1991663478","https://openalex.org/W1992103299","https://openalex.org/W1993337559","https://openalex.org/W1995397384","https://openalex.org/W1995701317","https://openalex.org/W1996594934","https://openalex.org/W1999684404","https://openalex.org/W2001138302","https://openalex.org/W2004174524","https://openalex.org/W2005024828","https://openalex.org/W2006465220","https://openalex.org/W2008236755","https://openalex.org/W2008679549","https://openalex.org/W2015780258","https://openalex.org/W2015803022","https://openalex.org/W2016929926","https://openalex.org/W2017012169","https://openalex.org/W2017974573","https://openalex.org/W2018664283","https://openalex.org/W2018978645","https://openalex.org/W2022024115","https://openalex.org/W2023241683","https://openalex.org/W2023446905","https://openalex.org/W2026308971","https://openalex.org/W2026316964","https://openalex.org/W2031829990","https://openalex.org/W2034805757","https://openalex.org/W2036349878","https://openalex.org/W2038922520","https://openalex.org/W2040939715","https://openalex.org/W2041909530","https://openalex.org/W2042326105","https://openalex.org/W2042765519","https://openalex.org/W2043526633","https://openalex.org/W2043666005","https://openalex.org/W2044292165","https://openalex.org/W2048049789","https://openalex.org/W2049823814","https://openalex.org/W2051778078","https://openalex.org/W2053877279","https://openalex.org/W2054720248","https://openalex.org/W2058179986","https://openalex.org/W2058435783","https://openalex.org/W2058764249","https://openalex.org/W2058775773","https://openalex.org/W2059250138","https://openalex.org/W2060127547","https://openalex.org/W2061298100","https://openalex.org/W2063980449","https://openalex.org/W2065505701","https://openalex.org/W2067168678","https://openalex.org/W2069119488","https://openalex.org/W2074043345","https://openalex.org/W2077235705","https://openalex.org/W2078848135","https://openalex.org/W2080893090","https://openalex.org/W2081320515","https://openalex.org/W2081500877","https://openalex.org/W2082980206","https://openalex.org/W2083743910","https://openalex.org/W2085586114","https://openalex.org/W2089271775","https://openalex.org/W2090817179","https://openalex.org/W2093923504","https://openalex.org/W2096063232","https://openalex.org/W2100531197","https://openalex.org/W2104801001","https://openalex.org/W2107940358","https://openalex.org/W2109693559","https://openalex.org/W2112436639","https://openalex.org/W2114039007","https://openalex.org/W2114349736","https://openalex.org/W2121190898","https://openalex.org/W2125435699","https://openalex.org/W2134345362","https://openalex.org/W2135370236","https://openalex.org/W2136256413","https://openalex.org/W2139783987","https://openalex.org/W2146575324","https://openalex.org/W2148808422","https://openalex.org/W2150994390","https://openalex.org/W2151254648","https://openalex.org/W2152362399","https://openalex.org/W2152525922","https://openalex.org/W2152553738","https://openalex.org/W2153775667","https://openalex.org/W2155605721","https://openalex.org/W2156150035","https://openalex.org/W2156732253","https://openalex.org/W2157007137","https://openalex.org/W2160155834","https://openalex.org/W2160295591","https://openalex.org/W2163239863","https://openalex.org/W2164193152","https://openalex.org/W2165274786","https://openalex.org/W2170817369","https://openalex.org/W2184995059","https://openalex.org/W2206560725","https://openalex.org/W2219971676","https://openalex.org/W2241197161","https://openalex.org/W2242212761","https://openalex.org/W2255252620","https://openalex.org/W2256550747","https://openalex.org/W2261058775","https://openalex.org/W2266161931","https://openalex.org/W2278101261","https://openalex.org/W2283880530","https://openalex.org/W2283944439","https://openalex.org/W2295252364","https://openalex.org/W2310208728","https://openalex.org/W2314526577","https://openalex.org/W2320464126","https://openalex.org/W2338550813","https://openalex.org/W2342013321","https://openalex.org/W2342471521","https://openalex.org/W2408316826","https://openalex.org/W2409205504","https://openalex.org/W2409685047","https://openalex.org/W2412936367","https://openalex.org/W2413663890","https://openalex.org/W2414815547","https://openalex.org/W2415188534","https://openalex.org/W2439004823","https://openalex.org/W2441140655","https://openalex.org/W2444591748","https://openalex.org/W2462490197","https://openalex.org/W2467999024","https://openalex.org/W2472778196","https://openalex.org/W2992921110","https://openalex.org/W2994129629"],"related_works":["https://openalex.org/W7095287683","https://openalex.org/W1762977483","https://openalex.org/W2992921110","https://openalex.org/W1599633780","https://openalex.org/W2008679549","https://openalex.org/W2310208728","https://openalex.org/W2065505701","https://openalex.org/W2342013321","https://openalex.org/W1993337559","https://openalex.org/W2018978645"],"abstract_inverted_index":{"BACKGROUND:":[0],"Creatine":[1],"kinase":[2],"plays":[3],"a":[4,91,176,208,267],"key":[5],"role":[6],"in":[7,157,166,222,226,248],"cellular":[8,184],"energy":[9,78,86,223],"transport.":[10],"The":[11],"enzyme":[12],"transfers":[13],"high-energy":[14,37],"phosphoryl":[15],"groups":[16],"from":[17,106,120,178],"mitochondria":[18],"to":[19,146,180,196],"subcellular":[20],"sites":[21],"of":[22,35,74,82,138,142,241],"ATP":[23,228],"hydrolysis,":[24],"where":[25],"it":[26,257],"buffers":[27],"ADP":[28],"concentration":[29],"by":[30,51],"catalyzing":[31],"the":[32,36,64,72,96,101,115,127,136,151],"reversible":[33],"transfer":[34],"phosphate":[38],"moiety":[39],"(P)":[40],"between":[41],"creatine":[42,46,163],"and":[43,80,94,104,117,122,154,164,187,230,244],"ADP.":[44],"Cellular":[45],"uptake":[47,186],"is":[48,56,258,266],"competitively":[49],"inhibited":[50],"beta-guanidinopropionic":[52,75,143,236],"acid.":[53],"This":[54],"substance":[55],"marked":[57,259],"as":[58,260],"safe":[59,261],"for":[60,262,269],"human":[61,263,270],"use,":[62,264],"but":[63],"effects":[65],"are":[66],"unclear.":[67],"Therefore,":[68],"we":[69,113,130],"systematically":[70],"reviewed":[71],"effect":[73,137,174],"acid":[76,144,160,237],"on":[77,148],"metabolism":[79,198,224],"function":[81],"tissues":[83,168],"with":[84,214,251],"high":[85],"demands.":[87],"METHODS:":[88],"We":[89],"performed":[90],"systematic":[92],"review":[93],"searched":[95,114],"electronic":[97],"databases":[98],"Pubmed,":[99],"EMBASE,":[100],"Cochrane":[102],"Library,":[103],"LILACS":[105],"their":[107],"inception":[108],"through":[109],"March":[110],"2011.":[111],"Furthermore,":[112],"internet":[116],"explored":[118],"references":[119],"textbooks":[121],"reviews.":[123],"RESULTS:":[124],"After":[125],"applying":[126],"inclusion":[128],"criteria,":[129],"retrieved":[131],"131":[132],"publications,":[133],"mainly":[134],"considering":[135],"chronic":[139],"oral":[140],"administration":[141],"(0.5":[145],"3.5%)":[147],"skeletal":[149,171,242],"muscle,":[150,172],"cardiovascular":[152],"system,":[153],"brain":[155,219],"tissue":[156,193,220],"animals.":[158],"Beta-guanidinopropionic":[159],"decreased":[161,209],"intracellular":[162],"phosphocreatine":[165],"all":[167],"studied.":[169],"In":[170,191,218],"this":[173,194],"induced":[175],"shift":[177,195],"glycolytic":[179],"oxidative":[181],"metabolism,":[182],"increased":[183,188],"glucose":[185],"fatigue":[189,239],"tolerance.":[190],"heart":[192],"mitochondrial":[197],"was":[199,204],"less":[200],"pronounced.":[201],"Myocardial":[202],"contractility":[203],"modestly":[205,252],"reduced,":[206],"including":[207],"ventricular":[210],"developed":[211],"pressure,":[212],"albeit":[213],"unchanged":[215],"cardiac":[216],"output.":[217],"adaptations":[221],"resulted":[225],"enhanced":[227],"stability":[229],"survival":[231,245],"during":[232,246],"hypoxia.":[233],"CONCLUSION:":[234],"Chronic":[235],"increases":[238],"tolerance":[240],"muscle":[243],"ischaemia":[247],"animal":[249],"studies,":[250],"reduced":[253],"myocardial":[254],"contractility.":[255],"Because":[256],"there":[265],"need":[268],"data.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
