{"id":"https://openalex.org/W2052816449","doi":"https://doi.org/10.1016/0197-4580(87)90059-5","title":"Age-related changes in metabolic responses to chronic monoamine depletion in central dopaminergic and serotonergic systems of rats treated with reserpine","display_name":"Age-related changes in metabolic responses to chronic monoamine depletion in central dopaminergic and serotonergic systems of rats treated with reserpine","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2052816449","doi":"https://doi.org/10.1016/0197-4580(87)90059-5","mag":"2052816449","pmid":"https://pubmed.ncbi.nlm.nih.gov/2436067"},"language":"en","primary_location":{"id":"doi:10.1016/0197-4580(87)90059-5","doi":"https://doi.org/10.1016/0197-4580(87)90059-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0197-4580(87)90059-5","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060441165","display_name":"S. Algeri","orcid":"https://orcid.org/0009-0001-9152-0831","observed_orcids":["https://orcid.org/0009-0001-9152-0831"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Algeri","raw_affiliation_strings":["Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081979241","display_name":"Guido Achilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Achilli","raw_affiliation_strings":["Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008157099","display_name":"Gabriella Calderini","orcid":"https://orcid.org/0009-0009-4187-7312","observed_orcids":["https://orcid.org/0009-0009-4187-7312"]},"institutions":[{"id":"https://openalex.org/I4210090560","display_name":"Fidia Farmaceutici (Italy)","ror":"https://ror.org/00dy5wm60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210090560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Calderini","raw_affiliation_strings":["Fidia Laboratories, Abano Terme (Padua) Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidia Laboratories, Abano Terme (Padua) Italy","institution_ids":["https://openalex.org/I4210090560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033032639","display_name":"Carlo Perego","orcid":"https://orcid.org/0000-0002-0259-0003","observed_orcids":["https://orcid.org/0000-0002-0259-0003"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Perego","raw_affiliation_strings":["Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080578570","display_name":"Franca Ponzio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Ponzio","raw_affiliation_strings":["Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157, Milan, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036086414","display_name":"Gino Toffano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090560","display_name":"Fidia Farmaceutici (Italy)","ror":"https://ror.org/00dy5wm60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210090560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Toffano","raw_affiliation_strings":["Fidia Laboratories, Abano Terme (Padua) Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidia Laboratories, Abano Terme (Padua) Italy","institution_ids":["https://openalex.org/I4210090560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.881,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68707083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"1","first_page":"61","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/monoamine-depletion","display_name":"monoamine depletion","score":0.8389999866485596},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.843999981880188},{"id":"https://openalex.org/keywords/dopamine-metabolism","display_name":"dopamine metabolism","score":0.8740000128746033},{"id":"https://openalex.org/keywords/serotonin-metabolism","display_name":"serotonin metabolism","score":1.0},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6389999985694885},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.878000020980835},{"id":"https://openalex.org/keywords/dopamine-metabolites","display_name":"dopamine metabolites","score":0.6259999871253967},{"id":"https://openalex.org/keywords/serotonin-metabolites","display_name":"serotonin metabolites","score":0.9639999866485596},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.765999972820282},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.9800000190734863},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.9380000233650208},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.9029629826545715},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.8744052648544312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7992861270904541},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7954308986663818},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.7531687021255493},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7318319082260132},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6689180731773376},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.655681848526001},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6392081379890442},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46869778633117676},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4161866307258606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2307577133178711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20265686511993408},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07094505429267883},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0197-4580(87)90059-5","doi":"https://doi.org/10.1016/0197-4580(87)90059-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0197-4580(87)90059-5","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},{"id":"pmid:2436067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2436067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of aging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306798","display_name":"Gustavus and Louise Pfeiffer Research Foundation","ror":"https://ror.org/05v4jan90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W631065715","https://openalex.org/W1546489406","https://openalex.org/W1970358969","https://openalex.org/W1982449770","https://openalex.org/W1985541783","https://openalex.org/W1987855116","https://openalex.org/W2000566556","https://openalex.org/W2017862524","https://openalex.org/W2018023984","https://openalex.org/W2022982292","https://openalex.org/W2025064775","https://openalex.org/W2035060487","https://openalex.org/W2056701910","https://openalex.org/W2058212340","https://openalex.org/W2072883732","https://openalex.org/W2076458763","https://openalex.org/W2080376160","https://openalex.org/W2110894929","https://openalex.org/W2228538113","https://openalex.org/W2329442555","https://openalex.org/W2409448124","https://openalex.org/W2603134290","https://openalex.org/W6632756860"],"related_works":["https://openalex.org/W2076458763","https://openalex.org/W1997129506","https://openalex.org/W2064806863","https://openalex.org/W2013003355","https://openalex.org/W1985541783","https://openalex.org/W2084643243","https://openalex.org/W1968607634","https://openalex.org/W2059825822","https://openalex.org/W2034356646","https://openalex.org/W2036795288"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
