{"id":"https://openalex.org/W2052782003","doi":"https://doi.org/10.1016/s0008-6363(02)00223-7","title":"Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation","display_name":"Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2052782003","doi":"https://doi.org/10.1016/s0008-6363(02)00223-7","mag":"2052782003","pmid":"https://pubmed.ncbi.nlm.nih.gov/12062327"},"language":"en","primary_location":{"id":"doi:10.1016/s0008-6363(02)00223-7","doi":"https://doi.org/10.1016/s0008-6363(02)00223-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0008-6363(02)00223-7","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2052782003"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055910478","display_name":"Jos\u00e9 Jalife","orcid":"https://orcid.org/0000-0003-0080-3500","observed_orcids":["https://orcid.org/0000-0003-0080-3500"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Jalife","raw_affiliation_strings":["Department of Pharmacology, SUNY Upstate Medical University, 766 Irving Avenue, Syracuse, NY 13210, USA. jalifej@upstate.edu","Department of Pharmacology, SUNY Upstate Medical University, 766 Irving Avenue, Syracuse, NY 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, SUNY Upstate Medical University, 766 Irving Avenue, Syracuse, NY 13210, USA. jalifej@upstate.edu","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Department of Pharmacology, SUNY Upstate Medical University, 766 Irving Avenue, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084511797","display_name":"Omer Berenfeld","orcid":"https://orcid.org/0000-0001-9532-7871","observed_orcids":["https://orcid.org/0000-0001-9532-7871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omer Berenfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040829312","display_name":"Moussa Mansour","orcid":"https://orcid.org/0000-0003-3326-9973","observed_orcids":["https://orcid.org/0000-0003-3326-9973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moussa Mansour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055910478"],"corresponding_institution_ids":["https://openalex.org/I20388574"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":3.8233,"has_fulltext":true,"cited_by_count":598,"citation_normalized_percentile":{"value":0.957877,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"54","issue":"2","first_page":"204","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.37130001187324524,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/curl","display_name":"rotor","score":0.609000027179718},{"id":"https://openalex.org/keywords/reentry","display_name":"reentry","score":0.7929999828338623},{"id":"https://openalex.org/keywords/atrial-arrhythmia-mechanisms","display_name":"atrial arrhythmia mechanisms","score":0.6000000238418579},{"id":"https://openalex.org/keywords/left-atrium","display_name":"left atrium","score":0.7369999885559082},{"id":"https://openalex.org/keywords/coronary-veins","display_name":"coronary veins","score":0.5049999952316284},{"id":"https://openalex.org/keywords/paroxysmal-atrial-fibrillation","display_name":"paroxysmal atrial fibrillation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chronic-atrial-fibrillation","display_name":"chronic atrial fibrillation","score":0.875},{"id":"https://openalex.org/keywords/atrial-activation-patterns","display_name":"atrial activation patterns","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7892489433288574},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6773570775985718},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6297470331192017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6239628791809082},{"id":"https://openalex.org/C2988455589","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Cardiac arrhythmia","level":3,"score":0.6115894913673401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6017252206802368},{"id":"https://openalex.org/C114021368","wikidata":"https://www.wikidata.org/wiki/Q189265","display_name":"Atrium (architecture)","level":3,"score":0.5063477754592896},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4910862445831299},{"id":"https://openalex.org/C2777720157","wikidata":"https://www.wikidata.org/wiki/Q7306947","display_name":"Reentry","level":2,"score":0.46333375573158264},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4632393717765808},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.4113170802593231},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.329559862613678},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14200633764266968},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001282","descriptor_name":"Atrial Flutter","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011667","descriptor_name":"Pulmonary Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016279","descriptor_name":"Atrial Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019054","descriptor_name":"Evoked Potentials, Motor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0008-6363(02)00223-7","doi":"https://doi.org/10.1016/s0008-6363(02)00223-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0008-6363(02)00223-7","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:12062327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12062327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5209618396","display_name":"Intercellular Communication and Impulse Propagation","funder_award_id":"P01HL039707","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6335542776","display_name":"SPATIO-TEMPORAL PERIODICITY IN ARTIAL FIBRILLATION","funder_award_id":"R01HL060843","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W58578392","https://openalex.org/W171447616","https://openalex.org/W1570611312","https://openalex.org/W1592811135","https://openalex.org/W1971707804","https://openalex.org/W1976123882","https://openalex.org/W1980609178","https://openalex.org/W1981532308","https://openalex.org/W1981588501","https://openalex.org/W1987328727","https://openalex.org/W1998807312","https://openalex.org/W2001317681","https://openalex.org/W2012377620","https://openalex.org/W2013502290","https://openalex.org/W2014960828","https://openalex.org/W2017179259","https://openalex.org/W2018438802","https://openalex.org/W2019922150","https://openalex.org/W2020998145","https://openalex.org/W2026610396","https://openalex.org/W2028599309","https://openalex.org/W2028744920","https://openalex.org/W2030262988","https://openalex.org/W2032916579","https://openalex.org/W2033891898","https://openalex.org/W2034282563","https://openalex.org/W2034786923","https://openalex.org/W2037462241","https://openalex.org/W2041770881","https://openalex.org/W2043312016","https://openalex.org/W2044498557","https://openalex.org/W2046778297","https://openalex.org/W2047681204","https://openalex.org/W2047731765","https://openalex.org/W2050688237","https://openalex.org/W2050795671","https://openalex.org/W2053276452","https://openalex.org/W2054388133","https://openalex.org/W2054582730","https://openalex.org/W2055366521","https://openalex.org/W2057819459","https://openalex.org/W2060368349","https://openalex.org/W2060772678","https://openalex.org/W2064419632","https://openalex.org/W2065703535","https://openalex.org/W2077456907","https://openalex.org/W2078125895","https://openalex.org/W2097861830","https://openalex.org/W2101914304","https://openalex.org/W2103810179","https://openalex.org/W2109944491","https://openalex.org/W2113686078","https://openalex.org/W2114511261","https://openalex.org/W2116491680","https://openalex.org/W2121378195","https://openalex.org/W2131537235","https://openalex.org/W2131984396","https://openalex.org/W2139011872","https://openalex.org/W2139255154","https://openalex.org/W2150674116","https://openalex.org/W2155307701","https://openalex.org/W2158163231","https://openalex.org/W2165006299","https://openalex.org/W2169030657","https://openalex.org/W2171365230","https://openalex.org/W2172069617","https://openalex.org/W2210639820","https://openalex.org/W2313203550","https://openalex.org/W2334176761","https://openalex.org/W2338918622","https://openalex.org/W2409437488","https://openalex.org/W2593137870","https://openalex.org/W2614895478","https://openalex.org/W2918598742","https://openalex.org/W2972087099","https://openalex.org/W4251811303","https://openalex.org/W4301890533"],"related_works":["https://openalex.org/W1994170913","https://openalex.org/W2134676100","https://openalex.org/W2998869846","https://openalex.org/W2313136205","https://openalex.org/W1980886728","https://openalex.org/W2757725684","https://openalex.org/W2171696015","https://openalex.org/W181992418","https://openalex.org/W2035918319","https://openalex.org/W2033891898"],"abstract_inverted_index":{"Atrial":[0],"fibrillation":[1],"(AF)":[2],"is":[3,29,49],"the":[4,11,27,39,46,76,88,102,115,118,141,160,166,186],"most":[5],"common":[6],"sustained":[7],"cardiac":[8,13,40],"arrhythmia":[9,28],"and":[10,78,99,111,135,169,190,197,208],"major":[12],"cause":[14],"of":[15,38,54,91,109,117,122,154],"stroke.":[16],"Recent":[17],"studies":[18,182],"in":[19,36,43,64,75,87,97,159],"patients":[20,100],"with":[21],"paroxysmal":[22,110],"AF":[23,113,144,195],"have":[24,67],"shown":[25],"that":[26,50,69,79,93,104,143],"triggered":[30],"by":[31,83,148],"focal":[32],"sources":[33,157],"localized":[34,158],"usually":[35],"one":[37],"veins.":[41],"However,":[42],"chronic":[44,112],"AF,":[45],"prevailing":[47],"theory":[48],"multiple":[51],"random":[52],"wavelets":[53],"activation":[55,82,92],"coexist":[56],"to":[57,184],"create":[58],"an":[59],"unorganized":[60],"atrial":[61],"rhythm.":[62],"Experiments":[63],"isolated":[65],"hearts":[66],"demonstrated":[68],"stable,":[70],"self-sustained":[71],"rotors":[72,85],"can":[73],"exist":[74],"atria":[77],"high":[80],"frequency":[81],"such":[84,172],"results":[86],"complex":[89],"patterns":[90],"characterize":[94],"AF.":[95,177],"Studies":[96],"animals":[98],"support":[101],"view":[103],"at":[105],"least":[106],"some":[107],"cases":[108],"are":[114],"result":[116],"uninterrupted":[119],"periodic":[120],"activity":[121],"discrete":[123],"reentrant":[124,156],"sites.":[125],"In":[126],"this":[127],"brief":[128],"review":[129],"article,":[130],"we":[131,179],"examine":[132],"historical":[133],"data":[134],"more":[136],"recent":[137],"experimental":[138],"evidence":[139,170],"behind":[140],"hypothesis":[142,174],"may":[145,202],"be":[146],"organized":[147],"one,":[149],"or":[150],"a":[151,173],"small":[152],"number":[153],"high-frequency":[155],"left":[161],"atrium.":[162],"We":[163],"then":[164],"discuss":[165],"potential":[167],"implications":[168],"supporting":[171],"for":[175,194],"human":[176],"Finally,":[178],"suggest":[180],"future":[181],"designed":[183],"unravel":[185],"detailed":[187],"molecular,":[188],"cellular":[189],"pathophysiological":[191],"mechanisms":[192],"responsible":[193],"initiation":[196],"maintenance.":[198],"The":[199],"work":[200],"discussed":[201],"open":[203],"potentially":[204],"exciting":[205],"new":[206],"diagnostic":[207],"therapeutic":[209],"possibilities.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}