{"id":"https://openalex.org/W2052726331","doi":"https://doi.org/10.1016/j.bbr.2014.12.035","title":"Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease","display_name":"Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease","publication_year":2014,"publication_date":"2014-12-23","ids":{"openalex":"https://openalex.org/W2052726331","doi":"https://doi.org/10.1016/j.bbr.2014.12.035","mag":"2052726331","pmid":"https://pubmed.ncbi.nlm.nih.gov/25541039"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbr.2014.12.035","doi":"https://doi.org/10.1016/j.bbr.2014.12.035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2014.12.035","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2052726331"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100349653","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0003-3943-6381","observed_orcids":["https://orcid.org/0000-0003-3943-6381"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039534047","display_name":"Carina Peritore","orcid":"https://orcid.org/0000-0002-1655-3959","observed_orcids":["https://orcid.org/0000-0002-1655-3959"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carina Peritore","raw_affiliation_strings":["Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053013885","display_name":"Jessica Ginsberg Rogers","orcid":"https://orcid.org/0000-0002-6344-670X","observed_orcids":["https://orcid.org/0000-0002-6344-670X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Ginsberg","raw_affiliation_strings":["Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108574943","display_name":"Jennifer Shih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Shih","raw_affiliation_strings":["Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031747877","display_name":"Siddharth Arun","orcid":"https://orcid.org/0000-0002-8698-7816","observed_orcids":["https://orcid.org/0000-0002-8698-7816"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth Arun","raw_affiliation_strings":["Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014807219","display_name":"Gizem D\u00f6nmez","orcid":"https://orcid.org/0000-0002-5121-8232","observed_orcids":["https://orcid.org/0000-0002-5121-8232"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gizem Donmez","raw_affiliation_strings":["Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: Gizem.Donmez@tufts.edu","Department of Neuroscience, Tufts University School of\u00a0Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: Gizem.Donmez@tufts.edu","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Neuroscience, Tufts University School of\u00a0Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014807219"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":5.158,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.95897528,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"281","issue":null,"first_page":"215","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt5","display_name":"SIRT5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nigrostriatal-dopaminergic-neurons","display_name":"nigrostriatal dopaminergic neurons","score":0.8629999756813049},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8040000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9549999833106995},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.9280877113342285},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6979962587356567},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6978315711021423},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5010671615600586},{"id":"https://openalex.org/C2776108821","wikidata":"https://www.wikidata.org/wiki/Q15335612","display_name":"SOD2","level":4,"score":0.4521711468696594},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.44158270955085754},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.43653666973114014},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4275311529636383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37276986241340637},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.35990312695503235},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3444516360759735},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3351336419582367},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26575708389282227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2395138144493103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23141011595726013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17203077673912048},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08423224091529846}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020267","descriptor_name":"MPTP Poisoning","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020267","descriptor_name":"MPTP Poisoning","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020267","descriptor_name":"MPTP Poisoning","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbr.2014.12.035","doi":"https://doi.org/10.1016/j.bbr.2014.12.035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2014.12.035","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},{"id":"pmid:25541039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25541039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332647","display_name":"Center for Neuroscience Research","ror":"https://ror.org/05wvpxv85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1506621956","https://openalex.org/W1522510037","https://openalex.org/W1964234314","https://openalex.org/W1971389338","https://openalex.org/W1975695493","https://openalex.org/W1992740290","https://openalex.org/W1993723077","https://openalex.org/W1995590349","https://openalex.org/W2005594217","https://openalex.org/W2022911097","https://openalex.org/W2025116212","https://openalex.org/W2027827026","https://openalex.org/W2031315586","https://openalex.org/W2042138106","https://openalex.org/W2042710774","https://openalex.org/W2058906042","https://openalex.org/W2059750004","https://openalex.org/W2089299823","https://openalex.org/W2090008797","https://openalex.org/W2094655287","https://openalex.org/W2106715610","https://openalex.org/W2117473844","https://openalex.org/W2121966499","https://openalex.org/W2124316003","https://openalex.org/W2143959688","https://openalex.org/W2152165298","https://openalex.org/W2157450952","https://openalex.org/W2161854858","https://openalex.org/W2162002416","https://openalex.org/W2169880855","https://openalex.org/W2333915371","https://openalex.org/W2793634050","https://openalex.org/W4235341424"],"related_works":["https://openalex.org/W2043874361","https://openalex.org/W4214710280","https://openalex.org/W2896383505","https://openalex.org/W1964456323","https://openalex.org/W1844916130","https://openalex.org/W2598432420","https://openalex.org/W2092107930","https://openalex.org/W4309366883","https://openalex.org/W1485300797","https://openalex.org/W2607248985"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}