{"id":"https://openalex.org/W2052672634","doi":"https://doi.org/10.4161/hv.2.6.3494","title":"rDEN2/4\u039430(ME), a Live Attenuated Chimeric Dengue Serotype 2 Vaccine, is Safe and Highly Immunogenic in Healthy Dengue-Na\u00efve Adults","display_name":"rDEN2/4\u039430(ME), a Live Attenuated Chimeric Dengue Serotype 2 Vaccine, is Safe and Highly Immunogenic in Healthy Dengue-Na\u00efve Adults","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2052672634","doi":"https://doi.org/10.4161/hv.2.6.3494","mag":"2052672634","pmid":"https://pubmed.ncbi.nlm.nih.gov/17106267"},"language":"en","primary_location":{"id":"doi:10.4161/hv.2.6.3494","doi":"https://doi.org/10.4161/hv.2.6.3494","is_oa":true,"landing_page_url":"https://doi.org/10.4161/hv.2.6.3494","pdf_url":null,"source":{"id":"https://openalex.org/S91403448","display_name":"Human Vaccines","issn_l":"1554-8600","issn":["1554-8600","1554-8619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4161/hv.2.6.3494","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079820450","display_name":"Anna P. Durbin","orcid":"https://orcid.org/0000-0002-6652-2851","observed_orcids":["https://orcid.org/0000-0002-6652-2851"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna P. Durbin","raw_affiliation_strings":["Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. adurbin@jhsph.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. adurbin@jhsph.edu","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108592514","display_name":"Julie H. McArthur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie H. McArthur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110033626","display_name":"Jennifer A. Marron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Marron","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080756322","display_name":"Joseph E. Blaney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Blaney","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046264354","display_name":"Bhavin Thumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavin Thumar","raw_affiliation_strings":["Bloomberg School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg School of Public Health","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020150360","display_name":"Kimberli A. Wanionek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberli Wanionek","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062733502","display_name":"Brian R. Murphy","orcid":"https://orcid.org/0000-0002-3771-5283","observed_orcids":["https://orcid.org/0000-0002-3771-5283"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian R. Murphy","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.6457,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.96570605,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"6","first_page":"255","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dengue-serotype-2","display_name":"dengue serotype 2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dengue-serotype-4","display_name":"dengue serotype 4","score":0.8450000286102295},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.8149999976158142},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9079999923706055},{"id":"https://openalex.org/keywords/viremia","display_name":"viremia","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7640737295150757},{"id":"https://openalex.org/C2779308166","wikidata":"https://www.wikidata.org/wiki/Q18388297","display_name":"Dengue vaccine","level":4,"score":0.752837061882019},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.7000954747200012},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.6697695255279541},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.6544154286384583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5393893718719482},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.5224270224571228},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5011575222015381},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4672650694847107},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.44363903999328613},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42613643407821655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4174576997756958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12372085452079773}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053059","descriptor_name":"Dengue Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053059","descriptor_name":"Dengue Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053059","descriptor_name":"Dengue Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053059","descriptor_name":"Dengue Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/hv.2.6.3494","doi":"https://doi.org/10.4161/hv.2.6.3494","is_oa":true,"landing_page_url":"https://doi.org/10.4161/hv.2.6.3494","pdf_url":null,"source":{"id":"https://openalex.org/S91403448","display_name":"Human Vaccines","issn_l":"1554-8600","issn":["1554-8600","1554-8619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines","raw_type":"journal-article"},{"id":"pmid:17106267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17106267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human vaccines","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.4161/hv.2.6.3494","doi":"https://doi.org/10.4161/hv.2.6.3494","is_oa":true,"landing_page_url":"https://doi.org/10.4161/hv.2.6.3494","pdf_url":null,"source":{"id":"https://openalex.org/S91403448","display_name":"Human Vaccines","issn_l":"1554-8600","issn":["1554-8600","1554-8619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1987682599","display_name":null,"funder_award_id":"N01 AI 15444","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4148969630","display_name":null,"funder_award_id":"UAI057168A","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2117750666","https://openalex.org/W7099965884","https://openalex.org/W2109019244","https://openalex.org/W2143638790","https://openalex.org/W2053857786","https://openalex.org/W2157955177","https://openalex.org/W1997329577","https://openalex.org/W1942171174","https://openalex.org/W2147155908","https://openalex.org/W2007680340"],"abstract_inverted_index":{"rDEN2/4Delta30(ME)":[0,32],"is":[1,171],"an":[2],"attenuated":[3],"chimeric":[4],"dengue":[5],"virus":[6,116,127],"in":[7,41,143,152,167],"which":[8],"the":[9,16,27,65,108,119,122,140,144,156,159],"prM":[10],"and":[11,58,67,71,94,102],"E":[12],"structural":[13],"proteins":[14],"of":[15,26,38,64,69,137,139,158,164],"DEN4":[17],"candidate":[18],"vaccine":[19,76,115,166],"rDEN4Delta30":[20],"have":[21],"been":[22],"replaced":[23],"by":[24,80],"those":[25],"prototypic":[28],"DEN2":[29,101],"NGC":[30],"virus.":[31],"was":[33,60,77,133],"evaluated":[34],"at":[35],"a":[36,90,168],"dose":[37],"1,000":[39],"PFU":[40],"20":[42],"healthy":[43],"dengue-na\u00efve":[44],"adult":[45],"volunteers.":[46,82],"Eight":[47],"volunteers":[48,132],"received":[49],"placebo.":[50],"Volunteers":[51],"were":[52,89],"monitored":[53],"closely":[54],"for":[55,62,135],"adverse":[56,86],"events":[57,87],"serum":[59],"collected":[61],"determination":[63],"level":[66],"duration":[68],"viremia":[70],"neutralizing":[72],"antibody":[73,105],"response.":[74],"The":[75,83,147],"well":[78],"tolerated":[79],"all":[81],"most":[84],"common":[85],"observed":[88],"transient":[91],"asymptomatic":[92],"rash":[93],"mild":[95],"neutropenia.":[96],"All":[97],"vaccines":[98],"seroconverted":[99],"to":[100],"maintained":[103],"significant":[104],"titers":[106],"throughout":[107],"six-month":[109],"trial":[110],"duration.":[111],"Eleven":[112],"vaccinees":[113],"had":[114],"recovered":[117],"from":[118,126,130],"blood":[120],"during":[121],"study.":[123],"RNA":[124],"derived":[125],"isolates":[128],"obtained":[129],"viremic":[131],"sequenced":[134],"confirmation":[136],"retention":[138],"Delta30":[141,148,160],"mutation":[142,149],"3'":[145],"UTR.":[146],"remained":[150],"unchanged":[151],"each":[153],"isolate,":[154],"confirming":[155],"stability":[157],"mutation.":[161],"Further":[162],"evaluation":[163],"this":[165],"tetravalent":[169],"formulation":[170],"warranted.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}