{"id":"https://openalex.org/W2052654772","doi":"https://doi.org/10.1158/0008-5472.can-11-0804","title":"Potent Antitumor Immunity Generated by a CD40-Targeted Adenoviral Vaccine","display_name":"Potent Antitumor Immunity Generated by a CD40-Targeted Adenoviral Vaccine","publication_year":2011,"publication_date":"2011-07-12","ids":{"openalex":"https://openalex.org/W2052654772","doi":"https://doi.org/10.1158/0008-5472.can-11-0804","mag":"2052654772","pmid":"https://pubmed.ncbi.nlm.nih.gov/21747119"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-11-0804","doi":"https://doi.org/10.1158/0008-5472.can-11-0804","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-0804","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/71/17/5827/2656629/5827.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/71/17/5827/2656629/5827.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003132990","display_name":"Basav N. Hangalapura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Basav N. Hangalapura","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059098786","display_name":"Dinja Oosterhoff","orcid":"https://orcid.org/0000-0001-8707-2266","observed_orcids":["https://orcid.org/0000-0001-8707-2266"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Dinja Oosterhoff","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967001","display_name":"Jan de Groot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Jan de Groot","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025153030","display_name":"Louis Boon","orcid":"https://orcid.org/0000-0002-0937-9171","observed_orcids":["https://orcid.org/0000-0002-0937-9171"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Louis Boon","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078324938","display_name":"Thomas T\u00fcting","orcid":"https://orcid.org/0000-0001-7146-0934","observed_orcids":["https://orcid.org/0000-0001-7146-0934"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Thomas T\u00fcting","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072068921","display_name":"Alfons J.M. van den Eertwegh","orcid":"https://orcid.org/0000-0003-2196-1233","observed_orcids":["https://orcid.org/0000-0003-2196-1233"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Alfons J. van den Eertwegh","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039709555","display_name":"Winald R. Gerritsen","orcid":"https://orcid.org/0000-0003-1110-9119","observed_orcids":["https://orcid.org/0000-0003-1110-9119"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Winald R. Gerritsen","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108504728","display_name":"Victor W. van Beusechem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Victor W. van Beusechem","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004481759","display_name":"Alexander V. Pereboev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Alexander Pereboev","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"David T. Curiel","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111739443","display_name":"Rik J. Scheper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":false,"raw_author_name":"Rik J. Scheper","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053105927","display_name":"Tanja D. de Gruijl","orcid":"https://orcid.org/0000-0003-1464-8978","observed_orcids":["https://orcid.org/0000-0003-1464-8978"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["DE","NL","US"],"is_corresponding":true,"raw_author_name":"Tanja D. de Gruijl","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Bioceros B.V., Utrecht, The Netherlands","Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Medical Oncology and 2Pathology, VU University Medical Center, Amsterdam; 3Bioceros B.V., Utrecht, The Netherlands; 4Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany; 5Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama; and 6Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Bioceros B.V., Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"Department of Dermatology, Lab of Experimental Dermatology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5053105927"],"corresponding_institution_ids":["https://openalex.org/I135140700","https://openalex.org/I204465549","https://openalex.org/I32389192","https://openalex.org/I4210108500","https://openalex.org/I4390039250"],"apc_list":null,"apc_paid":null,"fwci":2.2364,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.87381896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"71","issue":"17","first_page":"5827","last_page":"5837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.640999972820282},{"id":"https://openalex.org/keywords/dendritic-cell-targeting","display_name":"dendritic cell targeting","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.5860000252723694},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.46299999952316284},{"id":"https://openalex.org/keywords/dendritic-cell-transduction","display_name":"dendritic cell transduction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.6115081906318665},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5169888734817505},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5038177371025085},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44874143600463867},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4476175606250763},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4350399374961853},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4076428711414337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3651820421218872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35239678621292114},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2871829867362976},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23193973302841187},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1158/0008-5472.can-11-0804","doi":"https://doi.org/10.1158/0008-5472.can-11-0804","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-0804","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/71/17/5827/2656629/5827.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:21747119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21747119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/0e0693fe-d8ce-4cec-8101-e38731fa8d4d","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/0e0693fe-d8ce-4cec-8101-e38731fa8d4d","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hangalapura, B N, Oosterhoff, D, de Groot, J, Boon, L, Tuting, T, van den Eertwegh, A J M, Gerritsen, W R, van Beusechem, V W, Pereboev, A, Curiel, D T, Scheper, R J & de Gruijl, T D 2011, 'Potent anti-tumor immunity generated by a CD40-targeted adenoviral vaccine.', Cancer research, vol. 71, no. 17, pp. 5827-5837. https://doi.org/10.1158/0008-5472.CAN-11-0804","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/35794","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/35794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"71","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/96202","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/96202","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 71, 17, pp. 5827-37","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/96202","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/96202","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 71, 5827 - 37","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu2:oai:dare.ubvu.vu.nl:1871/35794","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/35794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 71(17), 5827","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/f3396973-d54b-4520-9651-828efc9b798e","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/f3396973-d54b-4520-9651-828efc9b798e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 71(17), 5827 - 5837. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-11-0804","doi":"https://doi.org/10.1158/0008-5472.can-11-0804","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-11-0804","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/71/17/5827/2656629/5827.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2763399707","display_name":"Capsid-incorporation of HIV antigens as a novel adenovirus HIV vaccine approach","funder_award_id":"R33AI076096","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052654772.pdf","grobid_xml":"https://content.openalex.org/works/W2052654772.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1533597444","https://openalex.org/W1588193878","https://openalex.org/W1756675794","https://openalex.org/W1760966156","https://openalex.org/W1964700512","https://openalex.org/W1966689370","https://openalex.org/W1971932771","https://openalex.org/W1977235797","https://openalex.org/W1996391900","https://openalex.org/W1997402902","https://openalex.org/W1998950440","https://openalex.org/W2002918113","https://openalex.org/W2004594163","https://openalex.org/W2008354940","https://openalex.org/W2008519462","https://openalex.org/W2011007492","https://openalex.org/W2012702409","https://openalex.org/W2013274873","https://openalex.org/W2018333644","https://openalex.org/W2026470830","https://openalex.org/W2026775720","https://openalex.org/W2039296300","https://openalex.org/W2041142673","https://openalex.org/W2049332097","https://openalex.org/W2049978415","https://openalex.org/W2069208866","https://openalex.org/W2071460404","https://openalex.org/W2072363179","https://openalex.org/W2074302783","https://openalex.org/W2075909997","https://openalex.org/W2092602684","https://openalex.org/W2102128760","https://openalex.org/W2102916120","https://openalex.org/W2104606168","https://openalex.org/W2108699145","https://openalex.org/W2112789179","https://openalex.org/W2114713912","https://openalex.org/W2117070575","https://openalex.org/W2120849735","https://openalex.org/W2121101479","https://openalex.org/W2147923855","https://openalex.org/W2148510816","https://openalex.org/W2153746213","https://openalex.org/W2158311244","https://openalex.org/W2162666572","https://openalex.org/W2165086907","https://openalex.org/W2169957856","https://openalex.org/W2316779014","https://openalex.org/W2320254486","https://openalex.org/W6676102054","https://openalex.org/W6677762080"],"related_works":["https://openalex.org/W2039296300","https://openalex.org/W1756675794","https://openalex.org/W1706161058","https://openalex.org/W1997402902","https://openalex.org/W2021763685","https://openalex.org/W2027040539","https://openalex.org/W2121101479","https://openalex.org/W2884618548","https://openalex.org/W2081573122","https://openalex.org/W2075909997"],"abstract_inverted_index":{"In":[0],"situ":[1],"delivery":[2],"of":[3,35,42,44,58,111,119,129,156,169,178,189,194],"tumor-associated":[4],"antigen":[5],"(TAA)":[6],"genes":[7],"into":[8],"dendritic":[9],"cells":[10,160],"(DC)":[11],"has":[12],"great":[13],"potential":[14],"as":[15],"a":[16,73,84,99,166],"generally":[17],"applicable":[18],"tumor":[19,68],"vaccination":[20,144],"approach.":[21],"Although":[22],"adenoviruses":[23],"(Ad)":[24],"are":[25],"an":[26],"attractive":[27],"vaccine":[28],"vehicle":[29],"in":[30,80,131,138,141,148,165,186],"this":[31],"regard,":[32],"Ad-mediated":[33],"transduction":[34,116,127],"DCs":[36,79,130,190],"is":[37],"hampered":[38],"by":[39],"the":[40,45,50,89,94,109,154,176],"lack":[41],"expression":[43],"Ad":[46,105,180],"receptor":[47],"CAR":[48,90],"on":[49],"DC":[51,53],"surface.":[52],"activation":[54],"also":[55],"requires":[56],"interaction":[57],"CD40":[59,107,151],"with":[60,88,108,162],"its":[61],"ligand":[62],"CD40L":[63,95],"to":[64,71,75,78,93,106],"generate":[65],"protective":[66],"T-cell-mediated":[67],"immunity.":[69,196],"Therefore,":[70],"create":[72],"strategy":[74],"target":[76],"Ads":[77],"vivo,":[81],"we":[82,113,125],"constructed":[83],"bispecific":[85],"adaptor":[86],"molecule":[87],"ectodomain":[91],"linked":[92],"extracellular":[96],"domain":[97],"via":[98],"trimerization":[100],"motif":[101],"(CFm40L).":[102],"By":[103],"targeting":[104,152,188],"use":[110,177],"CFm40L,":[112],"enhanced":[114],"both":[115],"and":[117,134,140,143,191],"maturation":[118],"cultured":[120],"bone":[121],"marrow-derived":[122],"DCs.":[123],"Moreover,":[124],"improved":[126,153],"efficiency":[128],"lymph":[132,146],"node":[133],"splenic":[135],"cell":[136],"suspensions":[137],"vitro":[139],"skin":[142],"site-draining":[145],"nodes":[147],"vivo.":[149],"Furthermore,":[150],"induction":[155,193],"specific":[157],"CD8(+)":[158],"T":[159],"along":[161],"therapeutic":[163],"efficacy":[164],"mouse":[167],"model":[168],"melanoma.":[170],"Taken":[171],"together,":[172],"our":[173],"findings":[174],"support":[175],"CD40-targeted":[179],"vectors":[181],"encoding":[182],"full-length":[183],"TAA":[184],"for":[185],"vivo":[187],"high-efficacy":[192],"antitumor":[195]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}