{"id":"https://openalex.org/W2052644594","doi":"https://doi.org/10.1080/10915810290096298","title":"The Subchronic Oral Toxicity of Ethane, 1,2-Bis(pentabromophenyl) (Saytex 8010) in Rats","display_name":"The Subchronic Oral Toxicity of Ethane, 1,2-Bis(pentabromophenyl) (Saytex 8010) in Rats","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2052644594","doi":"https://doi.org/10.1080/10915810290096298","mag":"2052644594","pmid":"https://pubmed.ncbi.nlm.nih.gov/12055017"},"language":"en","primary_location":{"id":"doi:10.1080/10915810290096298","doi":"https://doi.org/10.1080/10915810290096298","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10915810290096298","pdf_url":null,"source":{"id":"https://openalex.org/S191449406","display_name":"International Journal of Toxicology","issn_l":"1091-5818","issn":["1091-5818","1092-874X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111667588","display_name":"Marcia Hardy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115209984","display_name":"Albemarle (United States)","ror":"https://ror.org/02hwyte29","country_code":"US","type":"company","lineage":["https://openalex.org/I115209984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. L. Hardy","raw_affiliation_strings":["Albemarle Corporation, Baton Rouge, Louisiana, USA","Albemarle Corporation, Baton Rouge, Louisiana 70801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albemarle Corporation, Baton Rouge, Louisiana, USA","institution_ids":["https://openalex.org/I115209984"]},{"raw_affiliation_string":"Albemarle Corporation, Baton Rouge, Louisiana 70801, USA","institution_ids":["https://openalex.org/I115209984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061134579","display_name":"D. Margitich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Margitich","raw_affiliation_strings":["Pharmakon Research International, Ltd., Waverly, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmakon Research International, Ltd., Waverly, Pennsylvania, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085195645","display_name":"Larry J. Ackerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090135","display_name":"Experimental Pathology Laboratories","ror":"https://ror.org/00dv9aw81","country_code":"US","type":"company","lineage":["https://openalex.org/I4210090135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Ackerman","raw_affiliation_strings":["Experimental Pathology Laboratories, Inc., Herndon, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Laboratories, Inc., Herndon, Virginia, USA","institution_ids":["https://openalex.org/I4210090135"]}]},{"author_position":"last","author":{"id":null,"display_name":"R. L. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115209984","display_name":"Albemarle (United States)","ror":"https://ror.org/02hwyte29","country_code":"US","type":"company","lineage":["https://openalex.org/I115209984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. L. Smith","raw_affiliation_strings":["Albemarle Corporation, Baton Rouge, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albemarle Corporation, Baton Rouge, Louisiana, USA","institution_ids":["https://openalex.org/I115209984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.17836745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"3","first_page":"165","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brominated-flame-retardants","display_name":"brominated flame retardants","score":0.8289999961853027},{"id":"https://openalex.org/keywords/subchronic-oral-toxicity","display_name":"subchronic oral toxicity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/90-day-oral-toxicity","display_name":"90-day oral toxicity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/no-observed-adverse-effect-level","display_name":"no-observed-adverse-effect level","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/liver-weight","display_name":"liver weight","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7977632284164429},{"id":"https://openalex.org/C2779225474","wikidata":"https://www.wikidata.org/wiki/Q842424","display_name":"Urinalysis","level":3,"score":0.7326818704605103},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5514057874679565},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.5397712588310242},{"id":"https://openalex.org/C2777495288","wikidata":"https://www.wikidata.org/wiki/Q1755926","display_name":"No-observed-adverse-effect level","level":3,"score":0.5367587208747864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5215094685554504},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.512549877166748},{"id":"https://openalex.org/C2778206080","wikidata":"https://www.wikidata.org/wiki/Q856775","display_name":"Corn oil","level":2,"score":0.4808300733566284},{"id":"https://openalex.org/C2987526018","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food consumption","level":2,"score":0.46812903881073},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.433003693819046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42869582772254944},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.418795108795166},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4107482135295868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3873847723007202},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3657263219356537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.270307332277298},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.1842246949672699},{"id":"https://openalex.org/C48824518","wikidata":"https://www.wikidata.org/wiki/Q396340","display_name":"Agricultural economics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004980","descriptor_name":"Ethane","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004980","descriptor_name":"Ethane","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005411","descriptor_name":"Flame Retardants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006842","descriptor_name":"Hydrocarbons, Brominated","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019055","descriptor_name":"No-Observed-Adverse-Effect Level","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036401","descriptor_name":"Toxicity Tests, Chronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10915810290096298","doi":"https://doi.org/10.1080/10915810290096298","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10915810290096298","pdf_url":null,"source":{"id":"https://openalex.org/S191449406","display_name":"International Journal of Toxicology","issn_l":"1091-5818","issn":["1091-5818","1092-874X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Toxicology","raw_type":"journal-article"},{"id":"pmid:12055017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12055017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2144801075","https://openalex.org/W1989347185","https://openalex.org/W2083405092","https://openalex.org/W2336129168","https://openalex.org/W1992776345","https://openalex.org/W2087351300","https://openalex.org/W4231295128","https://openalex.org/W2530440043","https://openalex.org/W2897176362","https://openalex.org/W2011637849"],"abstract_inverted_index":{"Ethane,":[0],"1,2-bis(pentabromophenyl)":[1],"(EBP;":[2],"CAS":[3],"no.":[4],"8452-53-9)":[5],"dose":[6],"levels":[7],"of":[8,32,96,122,135,146,157,183,197],"0,":[9],"100,":[10],"320":[11],"and":[12,43,66,76,104,111,178,211],"1000":[13,176],"mg/kg/day":[14],"administered":[15],"to":[16,98,106,202,206],"rats":[17,91],"by":[18,119],"gavage":[19],"in":[20,39,46,60,79,89,132,144,151,161,169],"corn":[21],"oil":[22],"for":[23,155],"90":[24],"consecutive":[25],"days":[26],"produced":[27],"no":[28],"compound-related":[29],"clinical":[30,41],"signs":[31],"systemic":[33],"toxicity,":[34],"ocular":[35],"lesions,":[36],"or":[37,49,54,82,174,191],"alterations":[38],"urinalysis,":[40],"chemistry,":[42],"hematology":[44],"values":[45],"the":[47,120,123,133,147,170,184],"treated":[48],"recovery":[50,125],"groups.":[51],"No":[52,127,138],"biologically":[53],"toxicologically":[55],"significant":[56,70],"differences":[57,71],"were":[58,72,130,142],"observed":[59],"body":[61,63],"weights,":[62],"weight":[64,210],"gains,":[65],"food":[67],"consumption.":[68],"Statistically":[69],"found":[73,131],"between":[74],"control":[75],"high-dose":[77],"animals":[78],"mean":[80],"absolute":[81],"relative":[83],"liver":[84,93],"weights.":[85],"Histomorphological":[86],"evaluation":[87],"showed":[88],"male":[90],"low-grade":[92],"changes":[94,116,129,141],"consisting":[95],"minimal":[97,105],"slight":[99,107],"hepatocellular":[100],"vacuolation":[101],"(high-dose":[102],"males)":[103],"centrilobular":[108],"hepatocytomegaly":[109],"(high-":[110],"possibly":[112],"mid-dose":[113],"males).":[114],"These":[115],"had":[117],"resolved":[118],"end":[121],"28-day":[124,186],"period.":[126],"treatment-related":[128,139],"livers":[134],"female":[136],"rats.":[137,163],"histomorphologic":[140],"present":[143],"any":[145],"other":[148],"tissues":[149],"examined":[150],"either":[152],"sex,":[153],"except":[154],"evidence":[156],"aspirated":[158],"test":[159],"article":[160],"individual":[162],"The":[164],"90-day":[165],"EBP":[166],"no-adverse-effect":[167],"level":[168,189],"rat":[171],"was":[172,179],">":[173,190],"=":[175,192],"mg/kg/day,":[177],"consistent":[180],"with":[181],"that":[182],"preceding":[185],"study":[187],"(no-effect":[188],"1250":[193],"mg/kg/day).":[194],"EBP's":[195],"lack":[196],"toxicity":[198],"is":[199],"likely":[200],"related":[201],"poor":[203],"bioavailability":[204],"due":[205],"its":[207],"high":[208],"molecular":[209],"low":[212],"solubility.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}