{"id":"https://openalex.org/W2052623944","doi":"https://doi.org/10.1021/ja201792q","title":"In Vitro Evolution of Ligands to the Membrane Protein Caveolin","display_name":"In Vitro Evolution of Ligands to the Membrane Protein Caveolin","publication_year":2011,"publication_date":"2011-05-26","ids":{"openalex":"https://openalex.org/W2052623944","doi":"https://doi.org/10.1021/ja201792q","mag":"2052623944","pmid":"https://pubmed.ncbi.nlm.nih.gov/21615158","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3120933"},"language":"en","primary_location":{"id":"doi:10.1021/ja201792q","doi":"https://doi.org/10.1021/ja201792q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja201792q","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3120933","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087763245","display_name":"Sudipta Majumdar","orcid":"https://orcid.org/0000-0001-6738-2267","observed_orcids":["https://orcid.org/0000-0001-6738-2267"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudipta Majumdar","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018060592","display_name":"Agnes Hajduczki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agnes Hajduczki","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046493325","display_name":"Rosemarie Vithayathil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosemarie Vithayathil","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062553967","display_name":"Tivoli J. Olsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tivoli J. Olsen","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054346619","display_name":"Ryan Spitler","orcid":"https://orcid.org/0000-0002-7240-2741","observed_orcids":["https://orcid.org/0000-0002-7240-2741"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan M. Spitler","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084352259","display_name":"Aaron S. Mendez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron S. Mendez","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003074267","display_name":"Travis D. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis D. Thompson","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006888208","display_name":"Gregory A. Weiss","orcid":"https://orcid.org/0000-0003-0296-9846","observed_orcids":["https://orcid.org/0000-0003-0296-9846"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory A. Weiss","raw_affiliation_strings":["Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, and \u2021Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006888208"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3215,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.54099622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"133","issue":"25","first_page":"9855","last_page":"9862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.8949999809265137},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.8009999990463257},{"id":"https://openalex.org/keywords/t-20","display_name":"T-20","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hiv-1-envelope-glycoprotein","display_name":"HIV-1 envelope glycoprotein","score":0.6430000066757202},{"id":"https://openalex.org/keywords/affinity-maturation","display_name":"affinity maturation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ligand-discovery","display_name":"ligand discovery","score":0.7260000109672546},{"id":"https://openalex.org/keywords/membrane-protein-targeting","display_name":"membrane protein targeting","score":0.6129999756813049},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.8401896953582764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8312282562255859},{"id":"https://openalex.org/C2779403975","wikidata":"https://www.wikidata.org/wiki/Q24724230","display_name":"Caveolin","level":4,"score":0.7378984689712524},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.7007224559783936},{"id":"https://openalex.org/C2780870201","wikidata":"https://www.wikidata.org/wiki/Q17855958","display_name":"Caveolin 1","level":2,"score":0.6786866188049316},{"id":"https://openalex.org/C2777864359","wikidata":"https://www.wikidata.org/wiki/Q5090466","display_name":"Chemical genetics","level":3,"score":0.5232987999916077},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.5192422866821289},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5114697217941284},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5048640370368958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4674319624900818},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3234397768974304},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3216734826564789},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.20640015602111816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12472161650657654}],"mesh":[{"descriptor_ui":"D000077560","descriptor_name":"Enfuvirtide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015700","descriptor_name":"HIV Envelope Protein gp41","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015700","descriptor_name":"HIV Envelope Protein gp41","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023581","descriptor_name":"HIV Fusion Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1021/ja201792q","doi":"https://doi.org/10.1021/ja201792q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja201792q","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:21615158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21615158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2387714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3120933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3120933","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3120933","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.726.8035","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.726.8035","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.chem.uci.edu/%7Egweiss/reprints/Majumdar-JACS-11.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2387714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3120933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1906944726","display_name":"MARC U*STAR at the University of California, Irvine","funder_award_id":"T34GM069337","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2738508348","display_name":"Engineering Soluble Aggregation-Prone and Membrane-Bound Proteins","funder_award_id":"R01GM078528","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5328307658","display_name":"Virus-host interactions: a multi-scale training program","funder_award_id":"T32AI007319","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W6312680","https://openalex.org/W1227091703","https://openalex.org/W1507805168","https://openalex.org/W1590831713","https://openalex.org/W1982007062","https://openalex.org/W1984026469","https://openalex.org/W1985518475","https://openalex.org/W1993201479","https://openalex.org/W2000930446","https://openalex.org/W2003526183","https://openalex.org/W2011296187","https://openalex.org/W2020357919","https://openalex.org/W2026366849","https://openalex.org/W2030727312","https://openalex.org/W2035648221","https://openalex.org/W2036656105","https://openalex.org/W2046389334","https://openalex.org/W2051147707","https://openalex.org/W2056949060","https://openalex.org/W2057972192","https://openalex.org/W2062315382","https://openalex.org/W2064754325","https://openalex.org/W2068418997","https://openalex.org/W2069444054","https://openalex.org/W2071990847","https://openalex.org/W2080124363","https://openalex.org/W2088248586","https://openalex.org/W2091386390","https://openalex.org/W2097805746","https://openalex.org/W2119046783","https://openalex.org/W2124317881","https://openalex.org/W2127036217","https://openalex.org/W2132854782","https://openalex.org/W2132869487","https://openalex.org/W2134467061","https://openalex.org/W2140864856","https://openalex.org/W2165715933","https://openalex.org/W2171280615"],"related_works":["https://openalex.org/W7097651406","https://openalex.org/W2310158327","https://openalex.org/W2766465441","https://openalex.org/W2805388810","https://openalex.org/W2779723266","https://openalex.org/W2018624236","https://openalex.org/W7100492570","https://openalex.org/W3207429062","https://openalex.org/W2043922597","https://openalex.org/W63773879"],"abstract_inverted_index":{"Membrane":[0],"proteins":[1],"comprise":[2],"a":[3,34,91],"third":[4],"of":[5,40,59,73,83,118,154],"the":[6,27,38,71,78,87,98,133,140,147,155,167],"human":[7],"genome,":[8],"yet":[9],"present":[10],"challenging":[11],"targets":[12],"for":[13,37,70,97,169],"reverse":[14,67],"chemical":[15,68],"genetics.":[16],"For":[17],"example,":[18],"although":[19],"implicated":[20],"in":[21,139,160,175],"numerous":[22],"diseases":[23],"including":[24],"multiple":[25],"myeloma,":[26],"membrane":[28],"protein":[29],"caveolin-1":[30,74,106],"appears":[31],"to":[32,44,94,101,130],"offer":[33],"poor":[35],"target":[36],"discovery":[39,72],"synthetic":[41],"ligands":[42,75,107,151,156],"due":[43],"its":[45],"largely":[46],"unknown":[47],"structure":[48],"and":[49,55,120,172],"insolubility.":[50],"To":[51],"break":[52],"this":[53],"impasse":[54],"identify":[56],"new":[57],"classes":[58],"caveolae":[60,173],"controlling":[61],"lead":[62],"compounds,":[63],"we":[64],"applied":[65],"phage-based,":[66],"genetics":[69],"derived":[76],"from":[77],"anti-HIV":[79],"therapeutic":[80],"T20.":[81,115],"Substitution":[82],"homologous":[84],"residues":[85],"into":[86],"T20":[88,134],"sequence":[89],"used":[90],"process":[92],"analogous":[93],"medicinal":[95],"chemistry":[96],"affinity":[99,112,128,149],"maturation":[100],"bind":[102],"caveolin.":[103],"The":[104,164],"resultant":[105],"bound":[108],"with":[109,136,146,157],">1000-fold":[110],"higher":[111],"than":[113],"wild-type":[114],"Two":[116],"types":[117],"ELISAs":[119],"isothermal":[121],"titration":[122],"calorimetry":[123],"(ITC)":[124],"measurements":[125],"demonstrated":[126],"high":[127],"binding":[129],"caveolin":[131,150,159,171],"by":[132],"variants":[135],"K(d)":[137],"values":[138],"150":[141],"nM":[142],"range.":[143],"Microscopy":[144],"experiments":[145],"highest":[148],"confirmed":[152],"colocalization":[153],"endogenous":[158],"NIH":[161],"3T3":[162],"cells.":[163,177],"results":[165],"establish":[166],"foundation":[168],"targeting":[170],"formation":[174],"living":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
