{"id":"https://openalex.org/W2052609490","doi":"https://doi.org/10.3109/15569529209042591","title":"Osmotic Tolerance of Rabbit Corneal Endothelium in Tissue Culture","display_name":"Osmotic Tolerance of Rabbit Corneal Endothelium in Tissue Culture","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2052609490","doi":"https://doi.org/10.3109/15569529209042591","mag":"2052609490"},"language":"en","primary_location":{"id":"doi:10.3109/15569529209042591","doi":"https://doi.org/10.3109/15569529209042591","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15569529209042591","pdf_url":null,"source":{"id":"https://openalex.org/S29939878","display_name":"Journal of Toxicology Cutaneous and Ocular Toxicology","issn_l":"0731-3829","issn":["0731-3829","1532-2505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology: Cutaneous and Ocular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065240223","display_name":"Dale R. Meyer","orcid":"https://orcid.org/0000-0001-5130-4141","observed_orcids":["https://orcid.org/0000-0001-5130-4141"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale R. Meyer","raw_affiliation_strings":["Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035682572","display_name":"James P. McCulley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Mcculley","raw_affiliation_strings":["Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas","Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Ophthalmology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.5017,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59847106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"1","first_page":"31","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.4675000011920929,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.4675000011920929,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.1873999983072281,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-endothelium","display_name":"corneal endothelium","score":0.9179999828338623},{"id":"https://openalex.org/keywords/osmotic-stress-tolerance","display_name":"osmotic stress tolerance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.6079999804496765},{"id":"https://openalex.org/keywords/endothelial-cell-culture","display_name":"endothelial cell culture","score":0.578000009059906},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.75},{"id":"https://openalex.org/keywords/topical-drug-vehicles","display_name":"topical drug vehicles","score":0.7039999961853027},{"id":"https://openalex.org/keywords/osmolarity","display_name":"osmolarity","score":0.5659999847412109},{"id":"https://openalex.org/keywords/nucleotide-release","display_name":"nucleotide release","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.6140000224113464},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ophthalmic-drug-development","display_name":"ophthalmic drug development","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2775901793","wikidata":"https://www.wikidata.org/wiki/Q1189806","display_name":"Corneal endothelium","level":3,"score":0.7501729726791382},{"id":"https://openalex.org/C77056095","wikidata":"https://www.wikidata.org/wiki/Q543183","display_name":"Isotonic","level":2,"score":0.6664573550224304},{"id":"https://openalex.org/C14705128","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmole","level":2,"score":0.5447824597358704},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.5011136531829834},{"id":"https://openalex.org/C2778996431","wikidata":"https://www.wikidata.org/wiki/Q4849997","display_name":"Balanced salt solution","level":2,"score":0.49653035402297974},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.4872690439224243},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4769690930843353},{"id":"https://openalex.org/C90703135","wikidata":"https://www.wikidata.org/wiki/Q3287622","display_name":"Tissue culture","level":3,"score":0.4768180251121521},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4568023383617401},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.44205260276794434},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.43481868505477905},{"id":"https://openalex.org/C9603476","wikidata":"https://www.wikidata.org/wiki/Q193135","display_name":"Osmotic pressure","level":2,"score":0.42664584517478943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38653436303138733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3594028055667877},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3504038155078888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29501885175704956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23570886254310608},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17970019578933716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17869850993156433},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/15569529209042591","doi":"https://doi.org/10.3109/15569529209042591","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15569529209042591","pdf_url":null,"source":{"id":"https://openalex.org/S29939878","display_name":"Journal of Toxicology Cutaneous and Ocular Toxicology","issn_l":"0731-3829","issn":["0731-3829","1532-2505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology: Cutaneous and Ocular Toxicology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1222965","https://openalex.org/W81297145","https://openalex.org/W154414434","https://openalex.org/W339544742","https://openalex.org/W1270679239","https://openalex.org/W1775749144","https://openalex.org/W1870608827","https://openalex.org/W1907275234","https://openalex.org/W1972657414","https://openalex.org/W1976845620","https://openalex.org/W1981242585","https://openalex.org/W1981287456","https://openalex.org/W2003206487","https://openalex.org/W2008871222","https://openalex.org/W2014493967","https://openalex.org/W2036236567","https://openalex.org/W2050971162","https://openalex.org/W2053758506","https://openalex.org/W2053948042","https://openalex.org/W2055549378","https://openalex.org/W2064581184","https://openalex.org/W2066398047","https://openalex.org/W2070758612","https://openalex.org/W2078026645","https://openalex.org/W2116525470","https://openalex.org/W2322250679","https://openalex.org/W2403318393","https://openalex.org/W2417699669"],"related_works":["https://openalex.org/W2086687998","https://openalex.org/W2071953810","https://openalex.org/W1981242585","https://openalex.org/W7151417549","https://openalex.org/W2882414832","https://openalex.org/W4248356470","https://openalex.org/W2032217284","https://openalex.org/W4256448950","https://openalex.org/W7204478121","https://openalex.org/W2078528668"],"abstract_inverted_index":{"The":[0],"osmotic":[1],"tolerance":[2],"of":[3,26,42,51,63,74,94,128,161],"rabbit":[4],"corneal":[5],"endothelial":[6],"cultures":[7,66],"was":[8,36,57,99],"determined":[9],"for":[10,111,126,167,174,178],"a":[11,95],"balanced":[12,96],"salt":[13,97],"solution":[14,98],"and":[15,45,80,102,169,173],"various":[16],"pharmaceutical":[17,179],"vehicles":[18,130],"in":[19,48,83,114],"an":[20],"effort":[21],"to":[22,108],"determine":[23],"the":[24,27,40,52,61,64,91,109,123],"biocompatibility":[25],"different":[28],"formulations":[29,137],"after":[30,67],"4-128":[31],"min":[32],"exposures.":[33],"Acute":[34],"change":[35],"assessed":[37],"by":[38,59,117,143],"monitoring":[39],"release":[41],"radiolabeled":[43],"nucleotides":[44],"corresponding":[46],"changes":[47,82],"tissue":[49,78],"morphology":[50,62],"prelabeled":[53],"cultures.":[54],"Protracted":[55],"damage":[56],"evaluated":[58],"re-examining":[60],"same":[65],"24":[68],"hr":[69],"along":[70],"with":[71],"quantitative":[72],"measurements":[73],"residual":[75],"3H":[76],"release,":[77],"loss,":[79],"concomitant":[81],"protein":[84],"synthesis.":[85],"Our":[86],"testing":[87],"results":[88],"indicated":[89],"that":[90,158],"permissive":[92,124],"limit":[93],"between":[100],"200":[101],"400":[103],"mOsm,":[104],"which":[105,149],"is":[106],"comparable":[107],"guidelines":[110,177],"native":[112],"endothelium":[113],"situ":[115],"established":[116],"organ":[118],"perfusion":[119],"studies.":[120],"In":[121],"contrast,":[122],"limits":[125],"prototypes":[127],"intraocular":[129,153],"were":[131,138,145],"more":[132,147],"restricted,":[133],"since":[134],"only":[135],"isotonic":[136],"relatively":[139],"nontoxic.":[140],"Topical":[141],"vehicles,":[142],"comparison,":[144],"much":[146],"damaging,":[148],"probably":[150],"contraindicates":[151],"their":[152],"usage.":[154],"These":[155],"data":[156],"indicate":[157],"this":[159],"type":[160],"bioassay":[162],"can":[163],"be":[164],"used":[165],"effectively":[166],"screening":[168],"drug":[170],"development":[171],"programs,":[172],"establishing":[175],"accurate":[176],"formulations.":[180]},"counts_by_year":[],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2016-06-24T00:00:00"}