{"id":"https://openalex.org/W2052570866","doi":"https://doi.org/10.1046/j.1365-2958.2002.02738.x","title":"Molecular characterization of type III secretion signals via analysis of synthetic N\u2010terminal amino acid sequences","display_name":"Molecular characterization of type III secretion signals via analysis of synthetic N\u2010terminal amino acid sequences","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2052570866","doi":"https://doi.org/10.1046/j.1365-2958.2002.02738.x","mag":"2052570866","pmid":"https://pubmed.ncbi.nlm.nih.gov/11849536"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2958.2002.02738.x","doi":"https://doi.org/10.1046/j.1365-2958.2002.02738.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.2002.02738.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111550725","display_name":"Scott A. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE","US"],"is_corresponding":true,"raw_author_name":"Scott A. Lloyd","raw_affiliation_strings":["Department of Molecular Biology, Ume\u00e5 University, Sweden. scottloyd23@hotmail.com","Departments of Molecular Biology and","\u2020Present address: Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Ume\u00e5 University, Sweden. scottloyd23@hotmail.com","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Departments of Molecular Biology and","institution_ids":[]},{"raw_affiliation_string":"\u2020Present address: Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105836111","display_name":"Michael Sj\u00f6str\u00f3m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Michael Sj\u00f6str\u00f6m","raw_affiliation_strings":["Chemistry, Umea\u030a University, S-90187, Umea\u030a, Sweden","Chemistry, Ume\u00e5 University, S-90187, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry, Umea\u030a University, S-90187, Umea\u030a, Sweden","institution_ids":["https://openalex.org/I90267481"]},{"raw_affiliation_string":"Chemistry, Ume\u00e5 University, S-90187, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082920458","display_name":"Sara Andersson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Andersson","raw_affiliation_strings":["Departments of Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048866051","display_name":"Hans Wolf\u2010Watz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Wolf\u2010Watz","raw_affiliation_strings":["Departments of Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111550725"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I90267481"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":8.4868,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.98373913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"1","first_page":"51","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.4323999881744385,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.4323999881744385,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.38260000944137573,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.09669999778270721,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yersinia","display_name":"Yersinia","score":0.7229999899864197},{"id":"https://openalex.org/keywords/yope","display_name":"YopE","score":0.949999988079071},{"id":"https://openalex.org/keywords/yersinia-outer-proteins","display_name":"Yersinia outer proteins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8741587400436401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7770362496376038},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.7014844417572021},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6395283341407776},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.538023829460144},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5020477771759033},{"id":"https://openalex.org/C2777305461","wikidata":"https://www.wikidata.org/wiki/Q484940","display_name":"Isoleucine","level":4,"score":0.4956256151199341},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4923290014266968},{"id":"https://openalex.org/C2776255393","wikidata":"https://www.wikidata.org/wiki/Q132231","display_name":"Yersinia","level":3,"score":0.44888368248939514},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.44358983635902405},{"id":"https://openalex.org/C2777299769","wikidata":"https://www.wikidata.org/wiki/Q3707858","display_name":"Type (biology)","level":2,"score":0.41610807180404663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21242567896842957},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.1924183964729309},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15941756963729858},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10889837145805359},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015007","descriptor_name":"Yersinia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015007","descriptor_name":"Yersinia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2958.2002.02738.x","doi":"https://doi.org/10.1046/j.1365-2958.2002.02738.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.2002.02738.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},{"id":"pmid:11849536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11849536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W588812189","https://openalex.org/W1481884569","https://openalex.org/W1900006748","https://openalex.org/W1908152925","https://openalex.org/W1916327110","https://openalex.org/W1932645010","https://openalex.org/W1943148606","https://openalex.org/W1975304761","https://openalex.org/W1980767305","https://openalex.org/W2000023769","https://openalex.org/W2002875716","https://openalex.org/W2005211587","https://openalex.org/W2005305957","https://openalex.org/W2019978236","https://openalex.org/W2021706375","https://openalex.org/W2027880544","https://openalex.org/W2047809341","https://openalex.org/W2063323542","https://openalex.org/W2065842276","https://openalex.org/W2071947177","https://openalex.org/W2078048665","https://openalex.org/W2082887128","https://openalex.org/W2099399224","https://openalex.org/W2106132559","https://openalex.org/W2117072224","https://openalex.org/W2132091434","https://openalex.org/W2132417094","https://openalex.org/W2139761661","https://openalex.org/W2140873739","https://openalex.org/W2144375173","https://openalex.org/W2144878722","https://openalex.org/W2145545130","https://openalex.org/W2153134143","https://openalex.org/W2160084442","https://openalex.org/W2161940955","https://openalex.org/W2293579233"],"related_works":["https://openalex.org/W2002875716","https://openalex.org/W2019978236","https://openalex.org/W2065276461","https://openalex.org/W2162103629","https://openalex.org/W2084898137","https://openalex.org/W1740864638","https://openalex.org/W2068027478","https://openalex.org/W1548455920","https://openalex.org/W2082887128","https://openalex.org/W1982470594"],"abstract_inverted_index":{"Yersinia":[0],"species":[1],"utilize":[2],"a":[3,35,81,107],"type":[4,26,43,122],"III":[5,27,44,123],"secretion":[6,28,45,111,127],"system":[7],"to":[8,90,105],"inject":[9],"toxins,":[10],"called":[11],"Yops":[12,23],"(Yersinia":[13],"outer":[14],"proteins),":[15],"into":[16],"eukaryotic":[17],"cells.":[18],"The":[19,67,113],"N-termini":[20],"of":[21,42,52,63,99,120],"the":[22,40,53,100,117],"serve":[24],"as":[25,125],"signals,":[29,46],"but":[30],"they":[31],"do":[32],"not":[33],"share":[34],"consensus":[36],"sequence.":[37],"To":[38],"simplify":[39],"analysis":[41,98],"we":[47],"replaced":[48],"amino":[49],"acids":[50],"2-8":[51],"secreted":[54],"protein":[55],"YopE":[56,92],"with":[57],"all":[58],"permutations":[59],"(27":[60],"or":[61,76,87],"128)":[62],"synthetic":[64,101],"serine/isoleucine":[65],"sequences.":[66],"results":[68],"demonstrate":[69],"that":[70],"amphipathic":[71],"N-terminal":[72,110,118],"sequences,":[73],"containing":[74],"four":[75],"five":[77],"serine":[78],"residues,":[79],"have":[80],"much":[82],"greater":[83],"probability":[84],"than":[85],"hydrophobic":[86],"hydrophilic":[88],"sequences":[89,102,119],"target":[91],"for":[93,109],"secretion.":[94],"Multiple":[95],"linear":[96],"regression":[97],"was":[103],"used":[104],"obtain":[106],"model":[108,114],"signals.":[112,128],"accurately":[115],"classifies":[116],"native":[121],"substrates":[124],"efficient":[126]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
