{"id":"https://openalex.org/W2052560889","doi":"https://doi.org/10.1093/nar/gkf567","title":"Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins","display_name":"Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins","publication_year":2002,"publication_date":"2002-10-15","ids":{"openalex":"https://openalex.org/W2052560889","doi":"https://doi.org/10.1093/nar/gkf567","mag":"2052560889","pmid":"https://pubmed.ncbi.nlm.nih.gov/12384599","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/137131"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkf567","doi":"https://doi.org/10.1093/nar/gkf567","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkf567","pdf_url":"https://academic.oup.com/nar/article-pdf/30/20/4519/4280070/gkf567.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/30/20/4519/4280070/gkf567.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005374458","display_name":"Katsumi Kasashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"K. Kasashima","raw_affiliation_strings":["Department of Biology, Graduate School of Science and Technology, Kobe University, 1-1 Rokkodaicho, Nadaku, Kobe 657-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Graduate School of Science and Technology, Kobe University, 1-1 Rokkodaicho, Nadaku, Kobe 657-8501, Japan","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005374458"],"corresponding_institution_ids":["https://openalex.org/I65837984"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":0.7648,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.65706161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"20","first_page":"4519","last_page":"4526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hu-protein","display_name":"HU protein","score":0.9070000052452087},{"id":"https://openalex.org/keywords/elav-like-proteins","display_name":"ELAV-like proteins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hud","display_name":"HUD","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7549999952316284},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.8489999771118164},{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.9520000219345093},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mrna-stabilization","display_name":"mRNA stabilization","score":0.7480000257492065},{"id":"https://openalex.org/keywords/neuron-specific-proteins","display_name":"neuron-specific proteins","score":0.6520000100135803},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.838723361492157},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6928427219390869},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.6651746034622192},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5497449636459351},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5246971845626831},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5164299607276917},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.4950808584690094},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.41373807191848755},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3559451997280121},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2653005123138428},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21645519137382507},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067779","descriptor_name":"ELAV-Like Protein 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051959","descriptor_name":"ELAV Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkf567","doi":"https://doi.org/10.1093/nar/gkf567","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkf567","pdf_url":"https://academic.oup.com/nar/article-pdf/30/20/4519/4280070/gkf567.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1472075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/137131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:137131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/137131","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:12384599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12384599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.9842","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.9842","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/30/20/4519.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkf567","doi":"https://doi.org/10.1093/nar/gkf567","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkf567","pdf_url":"https://academic.oup.com/nar/article-pdf/30/20/4519/4280070/gkf567.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052560889.pdf","grobid_xml":"https://content.openalex.org/works/W2052560889.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1497442951","https://openalex.org/W1543920123","https://openalex.org/W1566478858","https://openalex.org/W1829380772","https://openalex.org/W1864145246","https://openalex.org/W1927844679","https://openalex.org/W1964457265","https://openalex.org/W1967554461","https://openalex.org/W1980060880","https://openalex.org/W1982369409","https://openalex.org/W1997190480","https://openalex.org/W2001504986","https://openalex.org/W2001846092","https://openalex.org/W2002282713","https://openalex.org/W2005558505","https://openalex.org/W2012630877","https://openalex.org/W2014851246","https://openalex.org/W2021273817","https://openalex.org/W2033305072","https://openalex.org/W2035261316","https://openalex.org/W2035869111","https://openalex.org/W2045309201","https://openalex.org/W2055930249","https://openalex.org/W2056200986","https://openalex.org/W2060708740","https://openalex.org/W2063574627","https://openalex.org/W2082551528","https://openalex.org/W2090979828","https://openalex.org/W2093625208","https://openalex.org/W2106061374","https://openalex.org/W2110594361","https://openalex.org/W2125439548","https://openalex.org/W2129649868","https://openalex.org/W2140073418","https://openalex.org/W2141539159","https://openalex.org/W2142206747","https://openalex.org/W2142664254","https://openalex.org/W2154925328","https://openalex.org/W2161629430","https://openalex.org/W2163805309","https://openalex.org/W2170120455","https://openalex.org/W2170375626","https://openalex.org/W2170429383","https://openalex.org/W2183024399"],"related_works":["https://openalex.org/W7096012073","https://openalex.org/W2749625613","https://openalex.org/W2103239365","https://openalex.org/W2121436606","https://openalex.org/W2125262718","https://openalex.org/W2203796204","https://openalex.org/W1998989083","https://openalex.org/W4224035246","https://openalex.org/W2045309201","https://openalex.org/W2085709349"],"abstract_inverted_index":{"Hu":[0,42,56,87,105],"proteins":[1,4,43,57],"are":[2,6,14],"RNA-binding":[3,98],"that":[5,40,52,81,124,138],"the":[7,29,34,53,67,85,125],"vertebrate":[8],"homologs":[9],"of":[10,21,69,84,128,144,147],"Drosophila":[11],"ELAV,":[12],"and":[13,62,100],"implicated":[15],"in":[16,28,59,66,74,90,116],"stabilization":[17],"or":[18],"enhanced":[19,65],"translation":[20],"specific":[22,97,135],"mRNAs":[23],"with":[24,46,103,108],"AU-rich":[25],"elements":[26],"(AREs)":[27],"3'-untranslated":[30],"region.":[31],"Here,":[32],"using":[33,73],"yeast":[35],"two-hybrid":[36],"system,":[37],"we":[38,79],"show":[39],"neuron-specific":[41,86],"can":[44,101],"interact":[45,102],"themselves.":[47],"Immuno":[48],"precipitation":[49],"assays":[50],"demonstrated":[51],"interaction":[54],"between":[55],"occurs":[58],"mammalian":[60],"cells":[61],"is":[63],"strongly":[64],"presence":[68],"cellular":[70],"RNA.":[71],"Furthermore,":[72],"situ":[75],"chemical":[76],"crosslinking":[77],"assays,":[78],"found":[80],"HuD,":[82],"one":[83],"proteins,":[88],"multimerizes":[89,130],"cells.":[91],"The":[92],"crosslinked":[93],"HuD":[94,112,129],"multimers":[95],"retain":[96],"ability":[99],"additional":[104],"proteins.":[106],"Consistent":[107],"this":[109],"biochemical":[110],"property,":[111],"showed":[113],"granular":[114,136],"distribution":[115],"two":[117],"neurogenic":[118],"cell":[119],"lines.":[120],"These":[121],"results":[122],"suggest":[123],"RNA-bound":[126],"form":[127,133],"cooperatively":[131],"to":[132],"a":[134,142],"structure":[137],"may":[139],"serve":[140],"as":[141],"site":[143],"post-transcriptional":[145],"regulation":[146],"ARE-containing":[148],"mRNAs.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}