{"id":"https://openalex.org/W2052553054","doi":"https://doi.org/10.1007/s00281-010-0213-0","title":"Autophagy and Tumorigenesis","display_name":"Autophagy and Tumorigenesis","publication_year":2010,"publication_date":"2010-06-29","ids":{"openalex":"https://openalex.org/W2052553054","doi":"https://doi.org/10.1007/s00281-010-0213-0","mag":"2052553054","pmid":"https://pubmed.ncbi.nlm.nih.gov/20589500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2999728"},"language":"en","primary_location":{"id":"doi:10.1007/s00281-010-0213-0","doi":"https://doi.org/10.1007/s00281-010-0213-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00281-010-0213-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00281-010-0213-0.pdf","source":{"id":"https://openalex.org/S54848071","display_name":"Seminars in Immunopathology","issn_l":"1863-2297","issn":["1863-2297","1863-2300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunopathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00281-010-0213-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045142674","display_name":"Srirupa Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srirupa Roy","raw_affiliation_strings":["Department of Pathology and Diller Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Ave, HSW450B, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Diller Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Ave, HSW450B, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001716925","display_name":"Jayanta Debnath","orcid":"https://orcid.org/0000-0002-8745-4069","observed_orcids":["https://orcid.org/0000-0002-8745-4069"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jayanta Debnath","raw_affiliation_strings":["Department of Pathology and Diller Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Ave, HSW450B, San Francisco, CA, 94143, USA","University of California\u2014San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Diller Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Ave, HSW450B, San Francisco, CA, 94143, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]},{"raw_affiliation_string":"University of California\u2014San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001716925"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":1.4796,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.8210989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"32","issue":"4","first_page":"383","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":1.0},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":1.0},{"id":"https://openalex.org/keywords/tumor-suppressor-function","display_name":"tumor suppressor function","score":0.7870000004768372},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/autophagy-markers","display_name":"autophagy markers","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9876102209091187},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7523071765899658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6146341562271118},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5165359377861023},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4712567627429962},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.46512672305107117},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4581843912601471},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.44248780608177185},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3952786922454834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1698969006538391},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11229735612869263},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1007/s00281-010-0213-0","doi":"https://doi.org/10.1007/s00281-010-0213-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00281-010-0213-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00281-010-0213-0.pdf","source":{"id":"https://openalex.org/S54848071","display_name":"Seminars in Immunopathology","issn_l":"1863-2297","issn":["1863-2297","1863-2300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunopathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2999728","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2999728","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Semin Immunopathol","raw_type":"Text"},{"id":"pmid:20589500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20589500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in immunopathology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.292.8772","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.8772","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8d/ab/Semin_Immunopathol_2010_Dec_30_32(4)_383-396.tar.gz","raw_type":"text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt5805r4rf","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5805r4rf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Seminars in Immunopathology, vol 32, iss 4","raw_type":"article"},{"id":"pmh:qt5805r4rf","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/5805r4rf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Roy, Srirupa; &amp; Debnath, Jayanta. (2010). Autophagy and Tumorigenesis. Seminars in Immunopathology, 32(4), pp 383-396. doi: 10.1007/s00281-010-0213-0. Retrieved from: http://www.escholarship.org/uc/item/5805r4rf","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s00281-010-0213-0","doi":"https://doi.org/10.1007/s00281-010-0213-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00281-010-0213-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00281-010-0213-0.pdf","source":{"id":"https://openalex.org/S54848071","display_name":"Seminars in Immunopathology","issn_l":"1863-2297","issn":["1863-2297","1863-2300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunopathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7311595021","display_name":null,"funder_award_id":"CA126792-S1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8713532897","display_name":null,"funder_award_id":"18XT-0106","funder_id":"https://openalex.org/F4320308294","funder_display_name":"Tobacco-Related Disease Research Program"},{"id":"https://openalex.org/G9000887830","display_name":"Autophagy and Pro-metastatic Differentiation","funder_award_id":"R01CA126792","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320308294","display_name":"Tobacco-Related Disease Research Program","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052553054.pdf","grobid_xml":"https://content.openalex.org/works/W2052553054.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W1594293927","https://openalex.org/W1599366903","https://openalex.org/W1784425676","https://openalex.org/W1918384196","https://openalex.org/W1963521777","https://openalex.org/W1963715674","https://openalex.org/W1965827991","https://openalex.org/W1970101770","https://openalex.org/W1970744454","https://openalex.org/W1971510147","https://openalex.org/W1971832552","https://openalex.org/W1972336737","https://openalex.org/W1972517547","https://openalex.org/W1972553173","https://openalex.org/W1972612572","https://openalex.org/W1972618720","https://openalex.org/W1974584534","https://openalex.org/W1979526109","https://openalex.org/W1979717090","https://openalex.org/W1981705266","https://openalex.org/W1983831622","https://openalex.org/W1984086503","https://openalex.org/W1989016316","https://openalex.org/W1989051519","https://openalex.org/W1991075835","https://openalex.org/W1992659717","https://openalex.org/W1993497779","https://openalex.org/W1993643473","https://openalex.org/W1997112179","https://openalex.org/W1997714593","https://openalex.org/W2008933923","https://openalex.org/W2009826571","https://openalex.org/W2014918593","https://openalex.org/W2019178802","https://openalex.org/W2019859798","https://openalex.org/W2025665129","https://openalex.org/W2036254130","https://openalex.org/W2037967087","https://openalex.org/W2039366561","https://openalex.org/W2039403501","https://openalex.org/W2040157483","https://openalex.org/W2041618813","https://openalex.org/W2042461504","https://openalex.org/W2043812762","https://openalex.org/W2047303826","https://openalex.org/W2054414559","https://openalex.org/W2055751151","https://openalex.org/W2056663185","https://openalex.org/W2056872519","https://openalex.org/W2060929195","https://openalex.org/W2061473417","https://openalex.org/W2064381459","https://openalex.org/W2064538938","https://openalex.org/W2065136628","https://openalex.org/W2065322400","https://openalex.org/W2065582101","https://openalex.org/W2066030465","https://openalex.org/W2066800765","https://openalex.org/W2066964642","https://openalex.org/W2068862752","https://openalex.org/W2070224555","https://openalex.org/W2073963703","https://openalex.org/W2078526927","https://openalex.org/W2080100430","https://openalex.org/W2081920342","https://openalex.org/W2085442981","https://openalex.org/W2086589626","https://openalex.org/W2086853865","https://openalex.org/W2092321143","https://openalex.org/W2096661568","https://openalex.org/W2097066287","https://openalex.org/W2100466458","https://openalex.org/W2101428185","https://openalex.org/W2104383425","https://openalex.org/W2104558541","https://openalex.org/W2105044604","https://openalex.org/W2106255061","https://openalex.org/W2106972520","https://openalex.org/W2108086395","https://openalex.org/W2109034822","https://openalex.org/W2109263914","https://openalex.org/W2110025151","https://openalex.org/W2111414495","https://openalex.org/W2113118283","https://openalex.org/W2113432343","https://openalex.org/W2113798012","https://openalex.org/W2113892331","https://openalex.org/W2115027029","https://openalex.org/W2115820946","https://openalex.org/W2115886998","https://openalex.org/W2119399459","https://openalex.org/W2122065834","https://openalex.org/W2131078803","https://openalex.org/W2133000461","https://openalex.org/W2134197723","https://openalex.org/W2134234801","https://openalex.org/W2146780639","https://openalex.org/W2146887271","https://openalex.org/W2149142217","https://openalex.org/W2149771125","https://openalex.org/W2150027419","https://openalex.org/W2150043714","https://openalex.org/W2151576707","https://openalex.org/W2152281757","https://openalex.org/W2154993563","https://openalex.org/W2155175976","https://openalex.org/W2155452700","https://openalex.org/W2156581417","https://openalex.org/W2158535498","https://openalex.org/W2161050915","https://openalex.org/W2169903226","https://openalex.org/W2170168836","https://openalex.org/W2170473989","https://openalex.org/W2268732392","https://openalex.org/W2283382919","https://openalex.org/W2510982895","https://openalex.org/W2792139654","https://openalex.org/W7098494784","https://openalex.org/W7099558388"],"related_works":["https://openalex.org/W7100148992","https://openalex.org/W2281792370","https://openalex.org/W2010977421","https://openalex.org/W2389925098","https://openalex.org/W3093747083","https://openalex.org/W4399850192","https://openalex.org/W4403240165","https://openalex.org/W4409105943","https://openalex.org/W2186308950","https://openalex.org/W2593410392"],"abstract_inverted_index":{"Autophagy,":[0],"a":[1,43],"catabolic":[2],"process":[3],"involved":[4],"in":[5,28,64,84,91,107],"the":[6,29,55,73,76,86,96],"sequestration":[7],"and":[8,32,63,75,94],"lysosomal":[9],"degradation":[10],"of":[11,34,57,82],"cytoplasmic":[12],"contents,":[13],"is":[14,48],"crucial":[15],"for":[16,88],"cellular":[17],"homeostasis.":[18],"The":[19],"current":[20],"literature":[21],"supports":[22],"that":[23,51,99],"autophagy":[24,40,52,83,90,106],"plays":[25],"diverse":[26],"roles":[27,81],"development,":[30],"maintenance,":[31],"progression":[33],"tumors.":[35],"While":[36],"genetic":[37],"evidence":[38,77],"indicates":[39],"functions":[41],"as":[42],"tumor":[44],"suppressor":[45],"mechanism,":[46],"it":[47],"also":[49],"apparent":[50],"can":[53],"promote":[54],"survival":[56],"established":[58],"tumors":[59],"under":[60],"stress":[61],"conditions":[62],"response":[65],"to":[66,103],"chemotherapy.":[67],"In":[68],"this":[69],"review,":[70],"we":[71],"discuss":[72],"mechanisms":[74],"underlying":[78],"these":[79],"multifaceted":[80],"tumorigenesis,":[85],"prospects":[87],"targeting":[89],"cancer":[92],"therapy,":[93],"overview":[95],"potential":[97],"markers":[98],"may":[100],"be":[101],"utilized":[102],"reliably":[104],"detect":[105],"clinical":[108],"settings.":[109]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
